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Veterinary suspension containing ceftiofur and baicalein and preparation method thereof

A ceftiofur and suspension technology is applied in the directions of medical preparations containing active ingredients, pharmaceutical formulations, liquid delivery, etc., to achieve the effects of simple production process, prolonging effective action time, and realizing industrialization.

Active Publication Date: 2018-09-25
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no research reports on compound drugs for the treatment of animal-derived MRSA at home and abroad.

Method used

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  • Veterinary suspension containing ceftiofur and baicalein and preparation method thereof
  • Veterinary suspension containing ceftiofur and baicalein and preparation method thereof
  • Veterinary suspension containing ceftiofur and baicalein and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Embodiment 1, preparation contains the compound suspension of ceftiofur baicalein

[0088] Its formula is as follows:

[0089]

[0090] The specific preparation method is as follows:

[0091] 1) Take the hydrogenated castor oil of the formula and add it to 0.5L soybean oil, heat and stir to dissolve it completely to obtain liquid A, and set aside;

[0092] 2) Pour 8L of soybean oil into the colloid mill, start the colloid mill, slowly add the prescribed amount of ceftiofur, grind for about 5 minutes, slowly add Span-80 and liquid A, and continue grinding for about 15 minutes.

[0093] 3) Slowly add the prescribed amount of baicalein and vitamin E, add soybean oil to 10L, and continue grinding for 15 minutes.

[0094] 4) Check the fineness of the particles: no less than 90% of the particles with a particle size of 15 μm or less, no less than 95% of the particles with a particle size of 20 μm or less, and no particles exceeding 50 μm. If the result meets the requirem...

Embodiment 2

[0095] Embodiment 2, preparation contains the compound suspension of ceftiofur baicalein

[0096] Its formula is as follows:

[0097]

[0098] The specific preparation method is as follows:

[0099] 1) Take the hydrogenated castor oil of the formula and add it to 0.5L soybean oil, heat and stir to dissolve it completely to obtain liquid A, and set aside;

[0100] 2) Pour 8L of soybean oil into the colloid mill, start the colloid mill, slowly add the prescribed amount of ceftiofur, grind for about 5 minutes, slowly add Span-80 and liquid A, and continue grinding for about 15 minutes.

[0101] 3) Slowly add the prescribed amount of baicalein and vitamin E, add soybean oil to 10L, and continue grinding for 15 minutes.

[0102] 4) Check the fineness of the particles: no less than 90% of the particles with a particle size of 15 μm or less, no less than 95% of the particles with a particle size of 20 μm or less, and no particles exceeding 50 μm. If the result meets the requirem...

Embodiment 3

[0103] Embodiment 3, preparation contains the compound suspension of ceftiofur baicalein

[0104] Its formula is as follows:

[0105]

[0106] The specific preparation method is as follows:

[0107] 1) Add hydrogenated castor oil and propyl gallate in 0.5L of glycerol triacetate in the prescribed amount, heat and stir to completely dissolve to obtain liquid A, and set aside;

[0108] 2) Take 8L triacetin and pour it into the colloid mill, start the colloid mill, slowly add the prescribed amount of ceftiofur, grind for about 5 minutes, slowly add Tween-80 and liquid A, and continue grinding for about 15 minutes.

[0109] 3) Slowly add the prescribed amount of baicalein, add soybean oil to 10L, and continue grinding for 15 minutes.

[0110] 4) Check the fineness of the particles: no less than 90% of the particles with a particle size of 15 μm or less, no less than 95% of the particles with a particle size of 20 μm or less, and no particles exceeding 50 μm. If the result mee...

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Abstract

The invention discloses a veterinary suspension containing ceftiofur and baicalein and a preparing method thereof.The veterinary suspension is formed in the mode that active constituents are dispersed into dispersing solvent, wherein the active constituents are ceftiofur and baicalein.Each 100 mL of suspension comprises 2.5-10 g of ceftiofur, 2.5-10 g of baicalein, and the balance dispersing solvent.According to the veterinary suspension containing ceftiofur and baicalein, oily solvent is adopted as the preparation dispersing solvent, in the oily suspension, the drug is released slowly, and for time-dependent antibiotics, T> MIC is prolonged, that is, the effective acting time is prolonged, feeding is conducted every 24 hours, and manpower and material resources are saved.The veterinary suspension containing ceftiofur and baicalein is obtained in the mode that ceftiofur and baicalein are dispersed into the dispersing solvent through a dispersing method, a suspending agent, a wetting agent and antioxygen are added, and a colloid mill is used for conducting grinding; the production technology is simple, cost is reduced, and industrialization is easily achieved.

Description

technical field [0001] The invention relates to a veterinary suspension containing ceftiofur and baicalein and a preparation method thereof, belonging to the field of animal husbandry pharmaceutical preparations. . Background technique [0002] Staphylococcus aureus is an important source of zoonotic infection, which can cause life-threatening diseases such as pneumonia, pericarditis, osteomyelitis, endocarditis, and sepsis. Since 1961, Jevons in England discovered methicillin-resistant Staphylococcus aureus (methicillin-resistant S.aureus, MRSA) for the first time, so far MRSA has spread almost all over the world and has become one of the important pathogenic bacteria of nosocomial infection. MRSA has multi-drug resistance characteristics, and more than 90% of clinically isolated MRSA strains are multi-drug resistant strains, often showing resistance to β-lactams, aminoglycosides, quinolones, tetracyclines, macrolides, forests, etc. Drug resistance to multiple antibiotics...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/546A61K31/352A61K9/10A61P31/04A61P29/00A61P11/00
CPCA61K9/10A61K31/352A61K31/546A61K47/44A61K2300/00
Inventor 汤树生肖希龙沈建忠钱民怡
Owner CHINA AGRI UNIV
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