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Chinese medicinal composition for preventing and treating renal ischemia reperfusion injury and preparation method thereof

A technology of renal ischemia reperfusion and composition, which is applied in the field of traditional Chinese medicine preparations, can solve the problems of aggravated kidney damage and aggravated cell metabolism disorder, and achieve the effects of good retention, short drying time and low energy consumption

Active Publication Date: 2016-07-20
黄国东
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Restoration of renal blood flow after ischemia exacerbates cellular metabolic disturbances, leading to aggravated renal injury

Method used

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  • Chinese medicinal composition for preventing and treating renal ischemia reperfusion injury and preparation method thereof
  • Chinese medicinal composition for preventing and treating renal ischemia reperfusion injury and preparation method thereof
  • Chinese medicinal composition for preventing and treating renal ischemia reperfusion injury and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A traditional Chinese medicine composition for preventing and treating renal ischemia-reperfusion injury, mainly made up of the following raw materials in parts by weight: 50 parts of Hydrangea japonica, 8 parts of Panax notoginseng, 12 parts of Coix Seed, 8 parts of Rhubarb, 12 parts of Astragalus 4 servings of licorice.

[0031] A preparation method of a traditional Chinese medicine composition for preventing and treating renal ischemia-reperfusion injury, comprising the following steps:

[0032] Step 1: Collect fresh hydrangea from July to September every year, spread it flat in a perforated tray, and dry it with superheated steam until its water content is less than 12%, to obtain hydrangea;

[0033] Step 2: Weigh the above-mentioned parts by weight of Hydrangea serrata and pulverize it to 30 meshes to obtain hydrangea powder; weigh the above-mentioned parts by weight of rhubarb, astragalus and licorice, mix and pulverize to 60 meshes to obtain the first mixed powder ; We...

Embodiment 2

[0044] A traditional Chinese medicine composition for preventing and treating renal ischemia-reperfusion injury, which is mainly made up of the following raw materials in parts by weight: 60 parts of hydrangea, 10 parts of panax notoginseng, 15 parts of coix seed, 10 parts of rhubarb, 15 parts of astragalus and 6 servings of licorice.

[0045] A preparation method of a traditional Chinese medicine composition for preventing and treating renal ischemia-reperfusion injury, comprising the following steps:

[0046] Step 1: Collect fresh hydrangea from July to September every year, spread it flat in a perforated tray, and dry it with superheated steam until its water content is less than 12%, to obtain hydrangea;

[0047] Step 2: Weigh the above-mentioned parts by weight of Hydrangea serrata and crush it to 40 meshes to obtain hydrangea powder; weigh the above-mentioned parts by weight of rhubarb, astragalus and licorice, mix and pulverize to 70 meshes to obtain the first mixed powder ; ...

Embodiment 3

[0058] A traditional Chinese medicine composition for preventing and treating renal ischemia-reperfusion injury, which is mainly made of the following raw materials in parts by weight: 70 parts of Hydrangea japonica, 12 parts of Panax notoginseng, 18 parts of Coix Seed, 12 parts of Rhubarb, 18 parts of Astragalus 8 servings of licorice.

[0059] A preparation method of a traditional Chinese medicine composition for preventing and treating renal ischemia-reperfusion injury, comprising the following steps:

[0060] Step 1: Collect fresh hydrangea from July to September every year, spread it flat in a perforated tray, and dry it with superheated steam until its water content is less than 12%, to obtain hydrangea;

[0061] Step 2. Weigh the above-mentioned parts by weight of Hydrangea serrata and crush it to 50 meshes to obtain hydrangea powder; Weigh the above-mentioned parts by weight of rhubarb, astragalus and licorice, mix and pulverize to 80 meshes to obtain the first mixed powder ...

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Abstract

The invention discloses a Chinese medicinal composition for preventing and treating renal ischemia reperfusion injury. The Chinese medicinal composition is mainly prepared from the following raw materials in parts by weight: 50-70 parts of galium aparine, 8-12 parts of radix notoginseng, 12-18 parts of semen coicis, 8-12 parts of prepared rheum officinale, 12-18 parts of radix astragali and 4-8 parts of radix glycyrrhizae. A preparation method of the Chinese medicinal composition for preventing and treating renal ischemia reperfusion injury mainly comprises the following steps: drying the galium aparine; mixing the prepared rheum officinale, the radix astragali and the radix glycyrrhizae, smashing the mixture, and performing trapezoidal reflux extraction on the smashed mixture with ethanol; smashing the galium aparine, and performing ultrasonic wave-assisted water extraction and ethanol reflux extraction on the smashed galium aparine; performing superfine grinding on the radix notoginseng and the semen coicis, and performing ultrasonic wave-assisted alcohol extraction; combining and concentrating extraction solutions. The Chinese medicinal composition has the effects of clearing heat, promoting diuresis, promoting blood circulation to remove blood stasis, eliminating evil without injuring healthy energy and strengthening healthy energy without retaining evil, and has remarkable prevention and treatment effects on renal ischemia reperfusion injury.

Description

Technical field [0001] The invention relates to the field of traditional Chinese medicine preparations. More specifically, the present invention relates to a traditional Chinese medicine composition for preventing and treating renal ischemia-reperfusion injury and a preparation method thereof. Background technique [0002] Ischemia reperfusion injury (Ischemia reperfusion injury, IRI) is clinically more common in operations such as blood loss or toxic shock, intravascular coagulation, kidney transplantation, partial nephrectomy, and renal parenchymal incision and stone removal. Restoring blood flow to the kidney after ischemia will aggravate cell metabolism disorder, leading to aggravated kidney damage. Ischemia-reperfusion injury is an important part of ischemic acute kidney injury, it is also a key part of the prevention and treatment of acute renal failure, and it is also the main factor that affects early renal function recovery and long-term survival in kidney transplantati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61P13/12
CPCA61K9/0095A61K36/258A61K36/481A61K36/484A61K36/53A61K36/708A61K36/8994A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 黄国东陈壮向少伟马晓露黄敏
Owner 黄国东
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