Method for improving Raman detection through electronic dynamic regulation of metal surface wettability
An electronic dynamic control, metal surface technology, applied in the field of femtosecond laser applications, can solve the problems of low efficiency, complex process, high cost, and achieve the effect of improving hydrophobicity, improving processing quality, and avoiding the accumulation of debris
Active Publication Date: 2016-07-20
BEIJING INSTITUTE OF TECHNOLOGYGY
View PDF4 Cites 9 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
[0004] The purpose of the present invention is to improve the problems of high cost, complex process and low efficiency in the preparation process of surface-enhanced Raman active substrates, and to provide a simple and efficient femtosecond laser pulse processing metal based on acetic acid-assisted electron dynamic regulation. Preparation method of Raman active substrate with hydrophobicity and Raman detection ability obtained on the surface
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment Construction
[0032] The present invention will be further described below in conjunction with the drawings and embodiments.
[0033] The method based on electronic dynamic control of metal surface wettability to improve Raman detection, the specific steps are as follows:
[0034] Step 1: Use a dual pulse generator based on Michelson interference principle to generate a femtosecond laser dual pulse sequence;
[0035] Step 2: The femtosecond laser double pulse sequence obtained in step 1 is incident perpendicularly to the surface of the sample, and is focused by the processed objective lens, and the focal point after laser focusing reaches the surface of the sample;
[0036] Step 3: Drop the acetic acid solution with a concentration of 99.5% into the petri dish where the sample is placed, so that it is about 3 mm below the sample;
[0037] Step 4. Find the focus again in the solution to ensure that the laser focus is on the upper surface of the sample. Since the laser has a self-focusing effect in the...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More Abstract
The invention relates to a method for improving Raman detection through electronic dynamic regulation of metal surface wettability and belongs to the technical field of femtosecond laser application.According to the method, substrate Raman detection capacity is improved by means of the characteristic of metal processed by means of a femtosecond laser dipulse sequence assisted by acetic acid that the surface is lyophobic and low in adhesion.The metal surface is processed by means of the femtosecond laser dipulse sequence assisted by acetic acid, an ordered three-dimensional conical structure is obtained by selecting proper laser parameters and scanning speed, the structure makes metal surface hydrophobicity improved and enables analyte molecule liquid drops to be contracted and aggregated in a confined space, then silver nanoparticle are deposited on the structured surface, electric field enhancement hot spots are provided for Raman detection, and then detection of low-concentration analyte to be detected can be achieved.The method is simple, efficient and low in cost, processing time is shortened by half, processing quality is improved, metal surface hydrophobicity is effectively improved, and sample surface-enhanced Raman detection capacity is improved.
Description
Technical field [0001] The invention relates to a method for improving Raman detection based on electronic dynamic control of metal surface wettability, which uses acetic acid-assisted femtosecond laser double pulse sequence to process the metal with its surface hydrophobic and low adhesion characteristics, and improves the substrate Raman detection ability. Femtosecond laser application technology field. Background technique [0002] Surface-enhanced Raman detection, as a simple and efficient detection method, is widely used in biomolecular detection, chemical composition analysis, molecular structure analysis and other fields. Its low-concentration detection capability is useful for detecting early diseased cells in the fields of biomedicine and chemistry. And toxic and harmful substances are of great significance, so the preparation of surface-enhanced Raman substrates has become a major research hotspot in the manufacturing industry. [0003] The preparation methods of surface...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 姜澜孟革李欣许永达
Owner BEIJING INSTITUTE OF TECHNOLOGYGY