A composite electrospinning device for preparing three-dimensional micro-nano conductive tissue engineering scaffolds

Abstract

The invention discloses a composite electrospinning device for manufacturing a three-dimensional micro-nano conductive tissue engineering scaffold. The composite electrospinning device comprises a portal frame, a near-field electrospinning nozzle, a far-field electrospinning nozzle, a near-field high-voltage power supply device, a far-field high-voltage power supply device and a collection vessel. A near-field X-axis motion platform and a far-field X-axis motion platform are arranged on the portal frame. A near-field Z-axis motion platform is arranged on the near-field X-axis motion platform. The near-field electrospinning nozzle is arranged on the near-field Z-axis motion platform. A far-field Z-axis motion platform is arranged on the far-field X-axis motion platform. The far-field electrospinning nozzle is arranged on the far-field Z-axis motion platform. A Y-axis motion platform is arranged below the portal frame. The collection vessel is arranged on the Y-axis motion platform. The near-field high-voltage power supply device can form an electric field between the near-field electrospinning nozzle and the collection vessel. The far-field high-voltage power supply device can form an electric field between the far-field electrospinning nozzle and the collection vessel. The composite electrospinning device is used for manufacturing the three-dimensional biological scaffold with conductivity, an extremely small fiber diameter, uniform wire diameter distribution, orderly fiber distribution and large enough thickness.

Description

technical field [0001] The invention is used in the technical field of composite electrospinning, and in particular relates to a composite electrospinning device for preparing a three-dimensional micro-nano conductive tissue engineering scaffold. Background technique [0002] Tissue engineering is a new interdisciplinary discipline developed in recent decades, including biology, material science, engineering and clinical medicine. Its core is to establish a three-dimensional composite composed of cells and biological materials. body. Among them, the role of the cell scaffold composed of biomaterials is to provide space for cell proliferation, so that cells can differentiate and proliferate according to the configuration of the biomaterial scaffold, and finally become the required tissue or organ. [0003] Since Ingvar demonstrated in 1920 that electrical stimulation had an effect on neurons cultured in vitro, it is generally believed that both the endogenous electric field ...

AI Technical Summary

Problems solved by technology

However, this technology cannot prepare ordered three-dimensional scaffolds, because when the deposited fibers are thick enough, there is charge accumulation in the fiber layer due to the inability of the fibers to conduct electricity, which in turn causes charge repulsion and the orderly deposition of nanofibers cannot continue, but It cannot use conductive materials, otherwise short circuits will occur during the preparation process

[0008] To sum up, there is still no general solution for preparing three-dimensional bioscaffolds with conductive properties, extremely small fiber diameters, uniform filament diameter distribution, orderly fiber distribution, and sufficient thickness.

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