Transdermal patch containing diclofenac epolamine and preparation method thereof
A technology of diclofenac epoamide and transdermal patch is applied in the field of diclofenac epoamide transdermal patch and preparation thereof, and can solve the problems of low bioavailability, low penetration rate of gel preparation and the like
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Embodiment 1
[0021] Single-dose prescription composition
[0022]
[0023] Preparation:
[0024] ① Weigh the prescribed amount of diclofenac eporamide and ethyl paraben, add it to propylene glycol, stir until dissolved, and set aside; first add the prescribed amount to neutralize sodium polyacrylate, sodium carboxymethyl cellulose, calcium carbonate, titanium dioxide, Polysorbate 80, stir evenly, then add the prescribed amount of glyoxate, stir evenly;
[0025] ②Preheat the prescribed amount of purified water to 50°C±2°C, add the prescribed amount of gelatin, povidone K90 and stir until dissolved, add the prescribed amount of edetate disodium and sorbitol, stir until dissolved, and keep warm;
[0026] ③Add the tartaric acid of the prescribed amount into the purified water according to the concentration (w / v) of 1.9%, and set aside;
[0027] ④ Slowly add the solution ② into the drug-containing solution ①; add the solution ③, and stir in vacuum for 3 minutes to obtain the drug-containin...
Embodiment 2
[0031] Single-dose prescription composition
[0032]
[0033] Preparation method: with embodiment 1.
Embodiment 3
[0035] Single-dose prescription composition
[0036]
[0037] Preparation method: with embodiment 1.
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Abstract
Description
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Application Information
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