Check patentability & draft patents in minutes with Patsnap Eureka AI!

Applications of aminolevulinic acid in treating fatty liver

A technology for aminolevulinic acid and fatty liver, which is applied in the field of metabolic syndrome and can solve problems such as unclear mechanism of action

Inactive Publication Date: 2016-08-24
叶芝藩 +1
View PDF2 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Tanaka Toru et al. (CN102164596A, CN103800310A) found that 5-ALA can prevent and improve, for example, selected from metabolic syndrome, diabetes, hyperlipidemia, hypertension, liver dysfunction, renal failure, obesity, erectile dysfunction, menopause Disability, sore shoulders, and low back pain in adults, but the exact mechanism of action is unclear
Whether 5-ALA can be used in the treatment of other metabolic syndromes remains to be confirmed.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Applications of aminolevulinic acid in treating fatty liver
  • Applications of aminolevulinic acid in treating fatty liver
  • Applications of aminolevulinic acid in treating fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1, establishment of obese mouse model

[0048] 1. Experimental animals:

[0049] Ten 8-week-old healthy male mice of c57BL / 6J strain were purchased from the Shanghai Experimental Animal Center of the Chinese Academy of Sciences. All the mice were kept in the SPF animal room of the Sixth People’s Hospital Affiliated to Shanghai Jiaotong University. Animal experiment license number: SYXK (Shanghai ) 2007-0005. SPF clean level breeding, room temperature (20±2°C), relative humidity 40%-70%, 12h of light per day, day and night cycle, free access to water and food.

[0050] 2. Establishment of obese mouse model:

[0051] After 8-week-old mice were fed with high-fat diet (45% high-fat diet, American Research Diet Company, product number D12451) for 3 months, a high-fat-induced obesity mouse model was established.

Embodiment 2

[0052] The detection of body weight and liver and fat weight of obese mice processed by embodiment 2,5-ALA

[0053] The obese mouse models that were successfully modeled were divided into two groups, and one group (treatment group) was gavaged with about 200ul 5-ALA (5mg / kg / day, a commercial product of Suzhou Yi'an Biotechnology Co., Ltd.) (n=5 ), another group (control group) was gavaged with about 200ul PBS (n=5).

[0054] 1. Mouse body weight and food intake monitoring

[0055] During the growth of the mice, the body weight of the mice was monitored as well as the food intake of the mice. The results showed that, compared with the control group, 5-ALA had no significant effect on the food intake of mice (see figure 1 A), can reduce the body weight of mice to a certain extent (see figure 1 B).

[0056] 2. Mouse liver and fat weight detection

[0057] After the obese mice were fed with 5-ALA and PBS for 9 weeks, the mice were anesthetized with sodium pentobarbital, and t...

Embodiment 3

[0058] The detection of glucose metabolism level in obese mice treated with embodiment 3, 5-ALA

[0059] 1. Changes of fasting blood glucose in mice

[0060] During the growth of the mice, the fasting blood glucose of the two groups of mice was detected after 12 hours of fasting every week to monitor the changes of their fasting blood glucose. The results showed that, compared with the control group, long-term treatment of 5-ALA can reduce the fasting blood glucose level of obese mice to some extent (see figure 2 A).

[0061] 2. Glucose Tolerance Test (GTT)

[0062] Glucose tolerance test was carried out after obese mice were fed with 5-ALA and PBS for 9 weeks. After the mice were starved for 16 hours, glucose (0.1g / kg body weight) was injected intraperitoneally, and the blood glucose values ​​before the glucose injection and 15, 30, 60 and 90 minutes after the glucose injection were detected with blood glucose test paper, and the glucose tolerance of the mice was observed. ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to prevention and treatment of metabolic syndrome, in particular fatty liver, in particular to a function and an application of aminolevulinic acid (5-ALA hereinafter) or a derivative thereof or salts of the aminolevulinic acid and the derivative thereof, as an active ingredient, in preventing, relieving and / or treating the fatty liver, and an application of the aminolevulinic acid in preparing medicines for preventing, relieving and / or treating the fatty liver.

Description

technical field [0001] The present invention relates to the prevention and treatment of metabolic syndrome, especially fatty liver. In particular, it relates to the function and application of aminolevulinic acid (hereinafter referred to as "5-ALA") or its derivatives, or their salts as active ingredients in the prevention, alleviation and / or treatment of fatty liver, and its use in the preparation of prevention, Applied in drugs for alleviating and / or treating fatty liver. Background technique [0002] Metabolic syndrome refers to the pathological state of metabolic disorders of proteins, fats, carbohydrates and other substances in the human body. Rate and hyperinsulinemia, these metabolic disorders are the pathological basis of heart, cerebrovascular disease and diabetes. [0003] Adipose tissue is an important energy storage organ. With excessive energy intake, if adipose tissue cannot expand its capacity through hyperplasia and differentiation to form new adipocytes, i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/197A61P1/16A61P5/50A61P3/04
Inventor 于浩泳
Owner 叶芝藩
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com