A gradient 3d printing nozzle and 3d printer

Abstract

The invention discloses a gradient 3D printing head and a 3D printer. The head comprises a liquid inlet runner, a mixing runner, a micro-reaction runner and a liquid outlet which are constructed in a micro-fluidic chip substrate, as well as a gradient mixing valve which is arranged on a mixing runner, wherein the liquid inlet runner comprises at least two liquid inlets and a plurality of liquid dividing runners which are branched from each of the liquid inlets; the liquid inlets are used for inputting corresponding to-be-mixed liquid printing materials; the various liquid dividing runners are connected to the mixing runner; the gradient mixing valve is matched with the mixing runner, and the gradient mixing valve is capable of displacing on the mixing runner in a driven mode, so that one part of the liquid dividing runners are disconnected, and meanwhile, the other part of the liquid dividing runners are turned on; therefore, a mixing proportion of the liquid printing materials which are inputted from the various liquid inlets is controlled; and the mixed liquid printing materials react in the micro-reaction runner, and then the mixed liquid printing materials are jetted from the liquid outlet. According to the gradient 3D printing head and the 3D printer disclosed by the invention, the mixing proportion and copolymerization of the printing materials can be quantitatively controlled, and a copolymerization speed can be accelerated, so that gradient-concentration multi-material 3D printing can be flexibly and rapidly achieved.

Description

technical field [0001] The invention relates to the field of biological 3D printing, in particular to a gradient 3D printing nozzle and a 3D printer. Background technique [0002] Tissue engineering technology is an interdisciplinary technology of biology and manufacturing, which aims to artificially manufacture tissues and organs through the expansion and assembly of autologous cells. Its development provides a new idea for tissue damage repair. The establishment of tissue engineering science marks that medicine will get rid of the limitation of organ transplantation and realize more reliable treatment. [0003] In tissue engineering research, composite and gradient cell scaffolds have received attention in recent years. Through the combination of various biomaterials with different physical, chemical and biological properties, heterogeneous and biomimetic artificial tissues can be obtained, which is of great significance to the heterogeneously distributed load-bearing str...

AI Technical Summary

Problems solved by technology

However, this method requires a long period of pre-configuration operations. For polymer biomaterials that require copolymerization reactions, temperature control and thorough mixing are required, which is cumbersome and time-consuming. In addition, this method requires multiple replacements when making cell scaffolds. Different concentrations of materials, low manufacturing precision, poor bonding between layers

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