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Quality detection method of hericium erinaceus tablets and application of hericium erinaceus tablets

A quality inspection method and Hericium erinaceus technology, which are applied to the quality testing method of Hericium erinaceus tablets and their product fields, and can solve problems such as batch quality differences of products with complex components.

Active Publication Date: 2016-09-21
广州白云山和记黄埔中药(亳州)有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Hericium erinaceus tablets use the whole as the active substance, so it is not enough to test the stability of Hericium erinaceus tablets only by measuring one or several active ingredients, and it cannot solve the problems of complex components and quality differences between product batches , and the quality control method of the HPLC fingerprint of Hericium erinaceus sheet that the present invention establishes then solves these deficiencies

Method used

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  • Quality detection method of hericium erinaceus tablets and application of hericium erinaceus tablets
  • Quality detection method of hericium erinaceus tablets and application of hericium erinaceus tablets
  • Quality detection method of hericium erinaceus tablets and application of hericium erinaceus tablets

Examples

Experimental program
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Embodiment 1

[0064] This embodiment is used to illustrate the quality detection method of Hericium erinaceus slices provided by the present invention.

[0065] Adopt the quality detection method of the present invention to carry out the detection of following steps to 1 batch of Hericium erinaceus sheets, can obtain the fingerprint collection of this batch of Hericium erinaceus sheets and the content thereof cytidine, adenine, uridine, adenosine and guanosine .

[0066] (1) Prepare mixed standard solution:

[0067] Accurately weigh appropriate amount of cytidine, adenine, uridine, adenosine and guanosine reference substances, respectively add water to prepare each 1mL containing 168.80μg cytidine, 57.50μg adenine, 199.20μg uridine, 198.00μg adenosine, 51.60μg Five solutions of guanosine, and then take an appropriate amount from these five solutions and mix them to obtain a solution containing 6.75 μg of cytidine, 4.60 μg of adenine, 31.87 μg of uridine, 31.68 μg of adenosine, and 4.13 μg ...

Embodiment 2

[0092] This embodiment is used to illustrate the quality detection method of Hericium erinaceus slices provided by the present invention.

[0093] This example further illustrates on the basis of Example 1 that the similarity between the fingerprints of Hericium erinaceus slices and the common pattern can be determined by the quality detection method of the present invention.

[0094] (6) Measure the fingerprints of 10 batches of Hericium erinaceus sheets according to the same method as the steps (1) to (5) of Example 1, then use the Chinese medicine chromatographic fingerprint similarity evaluation system to obtain 10 batches of Hericium erinaceus sheets The fingerprints of Hericium erinaceus are analyzed to obtain the common pattern of Hericium erinaceus sheets (see figure 2 , where R is the common pattern spectrum, S1 to S10 are the fingerprints of 10 batches of Hericium erinaceus slices respectively), and the similarity between the fingerprints of these 10 batches of Heri...

Embodiment 3

[0122] This embodiment is used to illustrate the quality detection method of Hericium erinaceus slices provided by the present invention.

[0123] On the basis of Examples 1 and 2, the present embodiment has measured the content of cytidine, adenine, uridine, adenosine and guanosine of other batches of Hericium erinaceus sheets by adopting the quality detection method of the present invention, and Its similarity to the consensus pattern map. Specific steps are as follows:

[0124] Get Hericium erinaceus sheet (lot number: 150322, Guangzhou Baiyunshan Hutchison Whampoa Traditional Chinese Medicine Co., Ltd.), according to the same method of steps (1) to (5) of Example 1, measure the cytidine and adenine of this Hericium erinaceus sheet , uridine, adenosine and guanosine were 26.98μg, 29.02μg, 167.11μg, 94.45μg, 32.88μg respectively.

[0125] Get this batch of Hericium erinaceus slices, measure its fingerprint according to the same method of the steps (1)~(5) of embodiment 1, ...

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Abstract

The invention provides a quality detection method of hericium erinaceus tablets. The method comprises steps as follows: (1) preparation of a mixed standard solution, (2) preparation of a test solution, (3) creating of chromatographic conditions, (4) drawing of a standard curve and regression calculation, (5) measurement of the test solution. The invention further provides the hericium erinaceus tablets obtained through detection with the quality detection method. By means of the quality detection method, the quality of the hericium erinaceus tablets can be comprehensively monitored, the stability of a production process is monitored, the stability, the uniformity and the controllability of a product are guaranteed, the method can also be used for identifying a counterfeit product, and accordingly, normal production and the circulation sequence of the variety of medicines are guaranteed.

Description

technical field [0001] The invention relates to a method for detecting medicine, in particular to a method for detecting the quality of hericium erinaceus tablets and a product thereof. Background technique [0002] Hericium erinaceus tablet is a tablet made of the water extract of Hericium erinaceus mycelium, which has the functions of nourishing qi and blood, strengthening the body, nourishing the stomach and protecting the stomach, and is often used clinically to treat gastric ulcer and duodenal ulcer And chronic gastritis, etc., have a good curative effect on a variety of digestive tract diseases. Hericium erinaceus tablets contain polysaccharides, polypeptides, nucleotides, amino acids and other components, which have the functions of immune regulation and protection of the gastrointestinal tract. [0003] The existing quality control methods of Hericium erinaceus tablets include spectrophotometry to determine the content of proteoglycan and high performance liquid chr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N2030/027
Inventor 张慧晔唐海明王德勤李楚源
Owner 广州白云山和记黄埔中药(亳州)有限公司