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A kind of pharmaceutical composition for treating liver disease and preparation method thereof

The technology of a composition and a medicine is applied in the field of pharmaceutical compositions for the treatment of liver diseases and the preparation field thereof, and can solve the problems of low yield of volatile oil of cinnabar, difficult operation of the inclusion process, and difficulty in meeting the actual production requirements of medicines and the like.

Active Publication Date: 2019-09-27
JIUZHITANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a pharmaceutical composition Yiganning granule for treating liver diseases and its preparation method, which can solve the problem that the yield of capillary volatile oil in the prior art is very low, which leads to the difficulty in the subsequent inclusion process, and it is difficult to meet the requirements of the drug. Technical problems required by actual production to ensure the quality of medicines

Method used

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  • A kind of pharmaceutical composition for treating liver disease and preparation method thereof
  • A kind of pharmaceutical composition for treating liver disease and preparation method thereof
  • A kind of pharmaceutical composition for treating liver disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] prescription

[0086]

[0087] method

[0088] For the above 13 flavors, decoct Astragalus with water twice, 2 hours each time, combine the decoction, filter, and concentrate the filtrate to a clear paste with a relative density of 1.25 (20°C);

[0089] Extract the volatile oil (in the form of aromatic water) from capillary capillary by straight-through distillation. The extraction time is 2 hours, and the capillary capillary aromatic water is collected; take 290g of β-cyclodextrin, add 5% ethanol to the total weight of the aromatic water, and stir in a water bath at 40°C-45°C Inclusion for 2 hours, refrigerated, and stand still for more than 12 hours; filter, wash with 29g ethanol for 3 times, dry at 40°C-45°C, crush through a 65-mesh sieve to obtain the inclusion compound of capillary volatile oil, and set aside;

[0090] Add the dregs and the rest of Codonopsis pilosula and other eleven flavors to decoct with water twice, each time for 2 hours, combine the decoct...

Embodiment 2

[0096] prescription

[0097]

[0098] method

[0099]For the above 13 flavors, decoct Astragalus with water twice, 2 hours each time, combine the decoction, filter, and concentrate the filtrate to a clear paste with a relative density of 1.25 (20°C);

[0100] Extract the volatile oil (in the form of aromatic water) from capillary capillary by straight-through distillation. The extraction time is 1.5 hours, and the capillary capillary aromatic water is collected; take 290g of β-cyclodextrin, add 2.5% ethanol to the total weight of the aromatic water, and stir in a water bath at 40°C-45°C Inclusion for 3 hours, refrigerated, and let stand for more than 12 hours; filter, wash twice with 58g of ethanol, dry at 35°C-40°C, crush through 80 mesh sieve to obtain capillary volatile oil inclusion compound, set aside;

[0101] Decoct the dregs and other eleven flavors such as Codonopsis pilosula twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate...

Embodiment 3

[0106] prescription

[0107]

[0108] method

[0109] For the above 13 flavors, decoct Astragalus with water twice, 2 hours each time, combine the decoction, filter, and concentrate the filtrate to a clear paste with a relative density of 1.25 (20°C);

[0110] Extract the volatile oil (in the form of aromatic water) from capillary capillary by straight-through distillation. The extraction time is 1 hour, and the capillary capillary aromatic water is collected; take 290g of β-cyclodextrin, add 10% ethanol to the total weight of the aromatic water, and stir in a water bath at 40°C-45°C Inclusion compound for 2.5 hours, refrigerated, and stand still for more than 12 hours; filter, wash with 45g ethanol for 4 times, dry at 45°C-50°C, crush and pass through a 65-mesh sieve to obtain the clathrate of capillary volatile oil, which is ready for use;

[0111] Decoct the dregs and other eleven flavors such as Codonopsis pilosula twice, each time for 2 hours, combine the decoction, f...

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Abstract

The invention provides a pharmaceutical composition for treating liver diseases and a preparing method thereof. Volatile oil (in the form of aromatic water) is extracted from herba artemisiae scopariae through distillation, the aromatic water is collected, beta-cyclodextrin is obtained, ethyl alcohol weighing 2.5-10% of the total weight of the aromatic water is added, stirring and clathration are conducted in a water bath which is 40-45 DEG C for 2-3 h, refrigeration and standing are conducted for 12 h or more, filtration is conducted, washing is conducted with a proper amount of ethyl alcohol for 2-4 times, drying is conducted at 35-50 DEG C, smashing and screening are conducted, and finally a herba artemisiae scopariae volatile oil clathrate compound is obtained. Compared with the prior art, the volatile active ingredients in herba artemisiae scopariae are fully transferred into the preparation, and therefore drug quality is guaranteed.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a pharmaceutical composition for treating liver diseases and a preparation method thereof. Background technique [0002] Yiganning Granules are recorded in Part 1 of the "Chinese Pharmacopoeia" 2010 Edition. The main ingredients are Astragalus, Hedyotis diffusa, Yin Chen, etc. The main functions and indications are to invigorate qi and strengthen the spleen, promote blood circulation and remove blood stasis, clear away heat and detoxify; it is used for chronic hepatitis. Deficiency of spleen-qi, blood stasis blocking collaterals, accumulation of damp-heat and toxin, symptoms include hypochondriac pain, abdominal distension, fatigue, and yellow urine; it also has a certain curative effect on acute hepatitis with the above-mentioned syndromes. However, in the actual production process of the preparation, the yield of the volatile oil of capillary...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/748A61K9/16A61K47/69A61P1/16
Inventor 黄胜谷陟欣辛秀朱丽谢安陈四娟戴向国
Owner JIUZHITANG