Seven-membered ring berberine analogue and its pharmaceutical composition, preparation method and application

A technology of berberine and analogs, which is applied in the fields of medicinal chemistry and pharmacotherapy, can solve the problems of large dosage, low oral bioavailability of berberine, affecting bioavailability and the like
CN105985349BActive Publication Date: 2020-01-14SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
Publication Date
2020-01-14

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Abstract

A seven-element-ring berberine analogue and pharmaceutically acceptable salt thereof. The seven-element-ring berberine analogue has the structure shown by formula A, and the definition of each substituted radical is as defined in the specification. Also provided are a preparation method of the seven-element-ring berberine analogue represented by formula A, and a use thereof in preparing medicine for preventing or treating tumors or cancer.
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Description

technical field

[0001] The invention relates to the fields of medicinal chemistry and drug therapeutics, in particular to a seven-membered ring berberine analogue for treating tumors, a pharmaceutical composition, a preparation method and a medical application thereof. Background technique

[0002] Traditional Chinese medicine is the treasure of the Chinese nation. Therefore, the development of modern innovative drug research based on active natural products is a research field that Chinese new drug research and development workers should pay close attention to. There are many active natural products extracted from Chinese herbal medicines that have been widely used, and berberine is one of them. Berberine, an isoquinoline alkaloid with the trade name of berberine, is mainly used to treat intestinal bacterial infections and is the main active ingredient in Chinese medicine Coptis chinensis.

[0003]

[0004] Coptis chinensis Franch (Coptis chinensis Franch), Coptis delto...

Claims

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