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Pharmaceutical composition of didanosine and application of pharmaceutical composition in biological medicines

A technology of didanosine and its composition, which is applied in the field of pharmaceutical composition and its application in biomedicine, and can solve the problems that have not yet been reported on the correlation between didanosine and its pharmaceutical composition and liver depression syndrome, To achieve the effect of improving the therapeutic effect

Inactive Publication Date: 2016-10-12
刘芊芊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between didanosine and its pharmaceutical composition and liver stagnation syndrome

Method used

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  • Pharmaceutical composition of didanosine and application of pharmaceutical composition in biological medicines
  • Pharmaceutical composition of didanosine and application of pharmaceutical composition in biological medicines
  • Pharmaceutical composition of didanosine and application of pharmaceutical composition in biological medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0018] Separation method: (a) Pulverize the small bone (3kg), extract with 75% ethanol under hot reflux (20L×3 times), combine the extracts, concentrate until no alcohol smell (4L), and successively use petroleum ether (4L×3 times), ethyl acetate (4L × 3 times) and water-saturated n-butanol (4L × 3 times) extraction to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) step ( a) Use AB-8 type macroporous resin to remove impurities from the n-butanol extract, first elute 8 column volumes with 6% ethanol, then elute 8 column volumes with 70% ethanol, collect 70% eluate, reduce Concentrate under pressure to get 70% ethanol elution concentrate; (c) in step (b), 70% ethanol elution concentrate is separated with normal phase silica gel, and the volume ratio is 50:1 (8 column volumes), 25:1 successively (8 column volumes), 15:1 (8 column volumes) and 5:1 (10 ...

Embodiment 2

[0021] Embodiment 2: pharmacological action

[0022] In this example, a rat model of liver stagnation syndrome was prepared by intragastric administration of thyroxine tablets and fed with abnormal hunger and fullness. It was observed that the drug reduced the plasma serotonin (5-hydroxytryptamine, 5-HT), norepinephrine (norepinephrine, NE), Epinephrine (epinephrine, E) level and other aspects of anti-liver depression effect.

[0023] 1. Materials and methods

[0024] 1.1 Animals

[0025] Adolescent healthy female SD rats, weighing (200±10) g, were fed ordinary solid feed, provided by the Experimental Animal Center of Xi'an Jiaotong University School of Medicine, and raised, observed and studied in the Physiology Laboratory of Xi'an Jiaotong University School of Medicine. Laboratory temperature (20±3)°C, humidity (55±5)°C, lighting and ventilation for 12 hours.

[0026] 1.2 Reagents and samples

[0027]Didanosine was purchased from China National Institute for the Control ...

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Abstract

The invention discloses a didanosine pharmaceutical composition and its application in biomedicine. The didanosine pharmaceutical composition provided by the invention contains didanosine and a novel structure natural product compound (I ), when didanosine and compound (I) act alone, it has a therapeutic effect on liver stagnation syndrome; when didanosine and compound (I) act in combination, the therapeutic effect on liver stagnation syndrome is significantly improved, and can be developed into a therapeutic Compared with the prior art, the medicine for liver depression syndrome has outstanding substantive characteristics and remarkable progress.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of didanosine, in particular to a pharmaceutical composition of didanosine and its application in biomedicine. Background technique [0002] Didanosine inhibits HIV replication. Under the action of cellular enzymes, it is transformed into the metabolite dideoxyadenosine triphosphate (ddATP), which has antiviral activity, and is an inhibitor of human immunodeficiency virus (HIV) replication. Its mechanism of action is similar to that of zidovudine. [0003] So far, there has been no report on the correlation between didanosine and its pharmaceutical composition and liver stagnation syndrome. Contents of the invention [0004] The object of the present invention is to provide a pharmaceutical composition of didanosine, which contains didanosine and a natural product with a novel structure, and didanosine and the natural product can synergistically treat liver depressio...

Claims

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Application Information

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IPC IPC(8): C07C69/73C07C67/48C07C67/54C07C67/56C07C67/58A61K31/22A61K31/708A61P1/16
CPCC07C69/73A61K31/22A61K31/708C07C67/48C07C67/54C07C67/56C07C67/58
Inventor 刘芊芊
Owner 刘芊芊
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