Antibacterial peptide SE37 and application thereof

A technology of SE37 and antimicrobial peptides, which is applied in the field of peptides in the field of biotechnology, can solve the problems of hemolysis, high toxicity, and poor inhibitory effect of eukaryotic cells

Active Publication Date: 2016-10-12
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For example, a considerable number of natural antimicrobial peptides have low antibacterial activity, poor stability, high toxicity, or cause hemolysis of eukaryotic cells; in addition, some antimicrobial peptides have poor inhibitory effects on drug-resistant bacteria, which cannot meet practical applications Requirements; artificial antimicrobial peptides obtained by modifying natural antimicrobial peptides or newly synthesizing can improve some or even all of the above shortcomings to a large extent to meet different application requirements

Method used

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  • Antibacterial peptide SE37 and application thereof
  • Antibacterial peptide SE37 and application thereof

Examples

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Embodiment Construction

[0012] Below in conjunction with embodiment technical solution of the present invention is further described:

[0013] The antimicrobial peptide SE37 product of the present invention is the amino acid sequence in SEQ ID NO. 1, and its sequence is: Ser-Glu-Thr-Arg-Pro-Val-Leu-Asn-Arg-Leu-Phe-Asp-Lys-Ile-Arg - Gln-Val-Ile-Arg-Lys-Phe-Glu-Lys-Gly-Ile-Lys-Glu-Lys-Ser-Lys-Arg-Phe-Phe-Asp-Gly-Leu-Leu.

[0014] Sequence features: the sequence type is amino acid sequence, containing 37 amino acid residues (the antimicrobial peptide can also be called antimicrobial peptide SE37), the molecular weight is 4504.40Da, the isoelectric point is 11.34, and the chain type is α-helical straight chain.

[0015] The antimicrobial peptide SE37 product in this example is synthesized by an automatic peptide synthesizer according to the conventional solid-phase polypeptide, and the finally obtained antimicrobial peptide SE37 is analyzed by high performance liquid chromatography, and its purity is ≥ 9...

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Abstract

The invention discloses an antibacterial peptide SE37, and belongs to the biotechnical field. The amino acid sequence of the antibacterial peptide SE37 is Ser-Glu-Thr-Arg-Pro-Val-Leu-Asn-Arg-Leu-Phe-Asp-Lys-Ile-Arg-Gln-Val-Ile-Arg-Lys-Phe-Glu-Lys-Gly-Ile-Lys-Glu-Lys-Ser-Lys-Arg-Phe-Phe-Asp-Gly-Leu-Leu. Experiments prove that the antibacterial peptide has an obvious inhibition effect on Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and four methicillin-resistant Staphylococcus aureuses, has the advantages of very low hemolysis activity, good stability, strong antibacterial activity and high-efficiency and wide-spectrum antibacterial effect, and can be used as an antibiotic substitute.

Description

technical field [0001] The invention relates to a polypeptide in the field of biotechnology, in particular to an antibacterial peptide SE37 and its application. Background technique [0002] Antimicrobial peptides (AMPs) are a class of small molecular active peptides encoded by genes and synthesized by ribosomes produced by organisms to defend against the invasion of external pathogens. They are important components of the innate defense system in organisms. As a biologically active small molecule, AMP generally has antibacterial, fungal, viral, and protozoan activities. In addition, it can also be used as a drug delivery carrier, antitumor agent, immune modulator, and signaling molecule. [0003] As an important class of clinical drugs, antibiotics have saved countless lives since they were used. However, in recent years, due to the increasing problems of drug abuse, drug residues and bacterial drug resistance, more and more countries have begun to seek alternatives to anti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/00A61K38/16A61P31/04
CPCA61K38/00C07K14/001Y02A50/30
Inventor 杨愈丰冯嘉敏夏嫱李均刘振勇张晓青向红英柳敦耀彭莉萍吕延成
Owner ZUNYI MEDICAL UNIVERSITY
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