Unlock instant, AI-driven research and patent intelligence for your innovation.

A traditional Chinese medicine composition for treating idiopathic pulmonary hypertension and its preparation method

A technology of pulmonary arterial hypertension and composition, applied in the field of medicine, can solve problems such as deterioration and corruption

Inactive Publication Date: 2017-04-19
HEILONGJIANG UNIV OF CHINESE MEDICINE
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] 4. Calcium channel blockers: The initial lesion of idiopathic pulmonary hypertension is in the vascular endothelium or smooth muscle, mainly vasoconstriction. Calcium channel blockers can reduce vasoconstriction, such as nifedipine, diltiazem, etc., but the use of such drugs Vasoreactivity testing needs to be done first to evaluate whether the patient is responding effectively to this class of drugs
However, the traditional Chinese medicine composition contains 9 traditional Chinese medicines, and contains animal viscera extract, which is easy to deteriorate and spoil

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A traditional Chinese medicine composition for treating idiopathic pulmonary hypertension and its preparation method
  • A traditional Chinese medicine composition for treating idiopathic pulmonary hypertension and its preparation method
  • A traditional Chinese medicine composition for treating idiopathic pulmonary hypertension and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1 Oral capsules for the treatment of idiopathic pulmonary hypertension and its preparation

[0055] The prescription of oral capsule for the treatment of idiopathic pulmonary hypertension is shown in the table below:

[0056]

[0057] Preparation:

[0058] 1) Take the prescribed amount of benzoin and dry paint, mash them separately, grind them into fine powder, and pass through an 80-mesh sieve for later use;

[0059] 2) Take the prescribed amount of Astragalus membranaceus, Ginkgo biloba, Polygonatum odoratum, Gentiana, and Salsa, and grind them separately, and pass through a 100-mesh sieve for later use;

[0060] 3) Mix the medicinal material powder obtained in step 1) and step 2), add water to decoct twice, add 6 times the weight of raw medicinal material for decoction for 4 hours for the first time, add 4 times the weight of raw medicinal material for decoction for the second time For 1 hour, combine the water decoction, concentrate the water decoction,...

Embodiment 2

[0064] Example 2 Oral Granules for Treating Idiopathic Pulmonary Hypertension and Its Preparation

[0065] The prescription of oral granules for the treatment of idiopathic pulmonary hypertension is shown in the table below:

[0066]

[0067] Preparation:

[0068] 1) Take the prescribed amount of benzoin and dry paint, mash them separately, grind them into fine powder, and pass through an 80-mesh sieve for later use;

[0069] 2) Take the prescribed amount of Astragalus membranaceus, Ginkgo biloba, Polygonatum odoratum, Gentiana, and Salsa, and grind them separately, and pass through a 100-mesh sieve for later use;

[0070] 3) Mix the medicinal material powder obtained in step 1) and step 2), add water to decoct twice, add 6 times the weight of raw medicinal material for decoction for 4 hours for the first time, add 4 times the weight of raw medicinal material for decoction for the second time For 1 hour, combine the water decoction, concentrate the water decoction, so tha...

Embodiment 3

[0074] Example 3 Oral liquid preparation for the treatment of idiopathic pulmonary hypertension and its preparation

[0075] The prescription of oral liquid formulations for the treatment of idiopathic pulmonary hypertension is shown in the table below:

[0076]

[0077] Preparation:

[0078] 1) Take the prescribed amount of benzoin and dry paint, mash them separately, grind them into fine powder, and pass through an 80-mesh sieve for later use;

[0079] 2) Take the prescribed amount of Astragalus membranaceus, Ginkgo biloba, Polygonatum odoratum, Gentiana, and Salsa, and grind them separately, and pass through a 100-mesh sieve for later use;

[0080] 3) Mix the medicinal material powder obtained in step 1) and step 2), add water to decoct twice, add 6 times the weight of raw medicinal material for decoction for 4 hours for the first time, add 4 times the weight of raw medicinal material for decoction for the second time For 1 hour, combine the water decoction, concentrat...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the field of medicines and relates to a traditional Chinese medicine composition for treating idiopathic pulmonary hypertension. The traditional Chinese medicine composition is prepared from 10-15 parts by weight of radix astragali, 10-15 parts by weight of ginkgo leaves, 10-15 parts by weight of radix polygonati officinalis, 10-15 parts by weight of felwort, 1-4 parts by weight of benzoin, 1-4 parts by weight of dried processed resin of Toxicodendron vernicifluum and 1-4 parts by weight of semen aesculi. The preparation method utilizes a water extraction and alcohol precipitation method. The traditional Chinese medicine composition is in a form of an oral preparation or an intravenous injection preparation. The traditional Chinese medicine composition substantially prolongs idiopathic pulmonary hypertension model rat survival time, reduces average pulmonary artery pressure and a right ventricular hypertrophy index and has good curative effects and safety to idiopathic pulmonary hypertension.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a traditional Chinese medicine composition for treating idiopathic pulmonary hypertension and a preparation method thereof. Background technique [0002] Idiopathic pulmonary arterial hypertension (IPAH) is a subtype of pulmonary arterial hypertension (PAH). The disease is a rare disease with a global incidence of about 1 to 2 people / 1 million people (Guo Xiaoxi, Su Chunfang. Advances in Drug Therapy for Idiopathic Pulmonary Hypertension. Advances in Cardiovascular Diseases, 2007, 28(2): 296-299.), the average survival period of patients is only 2.8 years, and the 1-, 3-, and 5-year survival rates are 68%, 48%, and 34% respectively (Wang Yi, Fang Weiwei. Advances in Drug Therapy for Idiopathic Pulmonary Hypertension . Cardiopulmonary Vascular Diseases, 2008, 27(6): 375-378.). Because the disease is a rare disease, there are few patients, the market is small, and there is no ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61P11/00A61P9/12
CPCA61K36/16A61K36/185A61K36/22A61K36/481A61K36/515A61K36/8969A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 左军刘凌宇郭倩
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE