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Preparation method fororal Pickering emulsion for sustained release of medicament

An emulsion and drug technology, applied in the field of emulsion, can solve the problems of single sodium alginate gel with large pore size, limited application of drug controlled release, weak mechanical strength, etc.

Active Publication Date: 2016-11-09
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, sodium alginate is highly hydrophilic, and its loading capacity for hydrophobic drugs is low, and its release rate is fast and prone to burst release. Weak, which limits its further application in controlled drug release

Method used

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  • Preparation method fororal Pickering emulsion for sustained release of medicament
  • Preparation method fororal Pickering emulsion for sustained release of medicament
  • Preparation method fororal Pickering emulsion for sustained release of medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A kind of preparation method of drug-loaded Pickering emulsion, its method step comprises:

[0027] (1) Take 50mL of 1% by mass sodium alginate solution, add 0.01g of potassium persulfate, mix well, add 5mL of 10% by mass diacetone acrylamide solution, react in an oil bath at 90°C for 3h, and obtain the product Purified with a Soxhlet extractor and dialyzed for 3 days.

[0028] (2) Take 25mL of liquid paraffin, add 1.25mL of Span80, mix well, respectively add 25mL of the above-mentioned modified sodium alginate solution and 3% calcium chloride solution at a rate of 1 drop / s to the above-mentioned In liquid paraffin, the modified sodium alginate emulsion and the calcium chloride emulsion were respectively obtained by shearing and emulsifying at 7000rpm for 5 minutes; the two emulsions were mixed, 10°C water bath, 1000rpm stirring reaction for 4h, the product was washed with a large amount of absolute ethanol, and the modified product was obtained by centrifugation. calc...

Embodiment 2

[0031] A kind of preparation method of drug-loaded Pickering emulsion, its method step comprises:

[0032] (1) Take 50mL of 1% by mass sodium alginate solution, add 0.01g of potassium persulfate, mix well, add 10mL of 10% by mass diacetone acrylamide solution, react in an oil bath at 90°C for 3h, and obtain the product Purified with a Soxhlet extractor and dialyzed for 3 days.

[0033] (2) Take 25mL of liquid paraffin, add 1.25mL of Span80, and mix well; respectively add 25mL of the above-mentioned modified sodium alginate solution and 5% calcium chloride solution at a rate of 1 drop / s to the above-mentioned liquid paraffin , 7000rpm shear emulsification for 5min to obtain modified sodium alginate emulsion and calcium chloride emulsion respectively; mix the two emulsions, 10℃ water bath, 1000rpm stirring reaction for 4h, the product is washed with a large amount of absolute ethanol, and centrifuged to obtain modified calcium alginate Microspheres.

[0034] (3) Disperse 0.4 g...

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Abstract

The invention provides a preparation method for an oral Pickering emulsion for sustained release of a medicament, particularly relates to the preparation method for a green non-toxic harmless oral Pickering emulsion and application of the oral Pickering emulsion in sustained or controlled release of the medicament, and belongs to the technical field of emulsion. Hydrophobic modified sodium alginate is prepared through free radical reaction of diacetone acrylamide and sodium alginate; hydrophobic modified calcium alginate particles are obtained by cross-linking the modified sodium alginate and calcium ions by utilizing a dual emulsion method; an O / W type Pickering emulsion is prepared by taking the hydrophobic calcium alginate particles as an emulsifier so that a micro-nano space for storing the medicament is formed to support a hydrophobic medicament, namely curcumin; therefore, the loading capacity and the sustained releasing performance of the medicament are improved, and the application of the Pickering emulsion in the aspect of medicament delivery is widened.

Description

technical field [0001] The invention relates to the preparation of a safe and non-toxic Pickering emulsion for oral administration and its slow-release performance, belonging to the technical field of emulsions. Background technique [0002] Pickering emulsion refers to a type of emulsion that replaces traditional emulsifiers with fine solid particles. The solid particles form a thin particle layer on the surface of the dispersed phase droplets, which prevents the coalescence of the droplets and effectively stabilizes the emulsion. The stability of the emulsion with solid particles as emulsifier depends on the particle size, surface wettability and the interaction between them, among which the wettability of particles is one of the important influencing factors. When the three-phase contact angle of the particles at the oil-water interface is about 90°, the solid particles can form a thin particle layer with a relatively stable structure at the oil-water interface, which ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K47/18A61K47/36A61K31/12
CPCA61K9/0002A61K9/0053A61K9/107A61K31/12A61K47/18A61K47/36
Inventor 张文君孙肖贺高红李敏范险林
Owner DALIAN UNIV OF TECH