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Preparation method of compound Lonicera japonica granules

A technology of compound honeysuckle and honeysuckle, which is applied to medical preparations, pharmaceutical formulations, plant raw materials and other directions containing active ingredients, can solve problems such as no trial verification, and achieve the effects of overcoming the loss of active ingredients, improving solubility, and improving stability.

Inactive Publication Date: 2016-11-09
HEBEI GOGIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main problem is that this patent document only discusses the internal structure of the vacuum belt dryer, and does not conduct trial verification for specific varieties.

Method used

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  • Preparation method of compound Lonicera japonica granules
  • Preparation method of compound Lonicera japonica granules
  • Preparation method of compound Lonicera japonica granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The preparation method of compound honeysuckle granules comprises the following process steps:

[0054] a, material preparation: respectively select, clean, cut and dry honeysuckle, forsythia and scutellaria baicalensis;

[0055] B, water extraction: the processed honeysuckle in step a is distilled with water, the distillate is collected, and the honeysuckle aqueous solution after distillation is centrifugally filtered at a high speed, the dregs of the honeysuckle after distillation are decocted with water and then centrifugally filtered at a high speed, and the filtrate is combined twice to reduce Press and concentrate to make the first honeysuckle thick paste with a relative density of 1.1-1.2; decoct the forsythia and scutellaria baicalensis treated in step a twice with water, combine the decoction and high-speed centrifugal filter, and concentrate the filtrate under reduced pressure to make a relative density The first forsythia scutellaria baicalensis mixed thick p...

Embodiment 2

[0068] The difference between this embodiment and embodiment 1 is:

[0069] The conditions for concentration under reduced pressure in step b are: temperature 80° C., pressure 0.05 MPa, and concentration time 24 hours.

[0070] The conditions for high-speed centrifugation in step b are: the rotation speed is 15,000 rpm, and the time is 10 minutes.

[0071] The conditions for concentration under reduced pressure in step c are: temperature 60° C., pressure 0.08 MPa, and time 24 hours.

[0072] The vacuum drying in the step d preferably adopts a vacuum belt dryer, and the process parameters of the belt dryer vacuum drying in the step d are: pressure 0.005 MPa, temperature 45 ° C, time 30 minutes, feed rate 83 kg / hours, the crawler speed is 3 cm / min.

[0073] All the other contents are the same as in Example 1.

Embodiment 3

[0075] The difference between this embodiment and embodiment 1 is:

[0076] The conditions for concentration under reduced pressure in step b are: temperature 70° C., pressure 0.04 MPa, and concentration time 36 hours.

[0077] The conditions for high-speed centrifugation in step b are: the rotation speed is 13000 rpm, and the time is 15 minutes.

[0078] The conditions for concentration under reduced pressure in step c are: temperature 58° C., pressure 0.04 MPa, and time 27 hours.

[0079] The vacuum drying in the step d preferably adopts a vacuum belt dryer, and the process parameters of the belt dryer vacuum drying in the step d are: pressure 0.003 MPa, temperature 42 ° C, time 45 minutes, feed rate 82 kg / hour, the crawler speed is 7 cm / min.

[0080] All the other contents are the same as in Example 1.

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Abstract

The invention belongs to the preparation of Chinese patent medicine and particularly relates to a preparation method of compound Lonicera japonica granules. The preparation method includes: preparing raw materials, performing water extraction, alcohol precipitation and vacuum drying, pelleting, and the like. The preparation method has the advantages that the problems that the prior art is long in production cycle, high in energy consumption, low in efficiency, poor in environment protection performance, complex in pelleting, and the like are solved, and the preparation method is low in effective component loss, short in process flow, low in production cost, low in energy consumption, and the like.

Description

technical field [0001] The invention belongs to the preparation of Chinese patent medicines, in particular to a preparation method of compound honeysuckle granules. Background technique [0002] Compound honeysuckle granule is made of honeysuckle, forsythia, and skullcap. It has the effects of clearing away heat and detoxification, cooling blood and reducing swelling. The efficacy of the compound traditional Chinese medicine is the result of the joint action of multiple components. In order to better control the contents of honeysuckle, forsythia and scutellaria baicalensis in the preparation, it is necessary to improve the preparation process of compound honeysuckle granules. [0003] The quality standard of Compound Honeysuckle Granules is not included in the Chinese Pharmacopoeia, and initially recorded in the tenth volume WS of Ministry-issued Standards for Traditional Chinese Medicine Preparations 3 -B-1985-95. It found no other dosage forms except granules in the dat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K36/634A61P11/00A61P11/04A61P27/02A61P1/02A61P17/02A61P29/00
CPCA61K36/355A61K9/1605A61K36/539A61K36/634A61K2236/331A61K2236/53A61K2300/00
Inventor 张四岩赵国强王建允
Owner HEBEI GOGIN PHARMA
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