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Far-field ultrasonic probe for sonodynamic therapy

A technology of sonodynamic therapy and ultrasonic probe, applied in the field of medical instruments, can solve the problems of insufficient precise quantification and controllable effect, inability to clarify the relationship between the effect data of sonodynamic therapy, etc., and achieves high engineering application value, wide application value and high efficiency. Effect

Active Publication Date: 2016-11-16
杨浩
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These nodes can cause undesired blind spots, and the precise quantification and controllable effect of therapeutic drugs is insufficient. It is impossible to clarify the effect of sonodynamic therapy and establish the relationship between the data of accurate ultrasonic dose therapy effect. The change of sound intensity tends to be stable in the far field area, so Ultrasound far-field effect probes need to be developed to improve the reliability of sonodynamic therapy devices

Method used

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  • Far-field ultrasonic probe for sonodynamic therapy
  • Far-field ultrasonic probe for sonodynamic therapy
  • Far-field ultrasonic probe for sonodynamic therapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] figure 1 It is a structural schematic diagram of the far-field ultrasonic probe of the present invention; as figure 1As shown, the ultrasonic probe includes an ultrasonic transducer 1, an upper ultrasonic transmission cavity 2, an electric displacement axis 3, an electric displacement axis controller connection 4, a corrugated expander 5, a lower ultrasonic transmission cavity 6, and an ultrasonic sound-absorbing layer 7. Ultrasonic coupling layer 8, ultrasonic transducer controller connection 9, water inlet 10, water outlet 11. Ultrasonic transducer 1, upper ultrasonic transmission cavity 2, electric displacement axis 3, corrugated expander 5, lower ultrasonic transmission cavity 6, ultrasonic sound-absorbing layer 7 and ultrasonic coupling layer 8; the upper ultrasonic transmission cavity 2 One end is fixedly connected with the ultrasonic transducer 1, and the other end is connected with one end of the bellows expander 5; the other end of the bellows expander 5 is co...

Embodiment 2

[0043] The difference between embodiment 2 and embodiment 1 lies in that the frequency used is 1.5 MHz, the diameter of the ceramic disk inside the transducer is 3.5 cm, and when the ultrasonic wave propagates in water, the length of the near-field region is about 31 cm. At this time, according to the ultrasonic frequency used by the transducer and the treatment, the length of the corrugated retractor 5 is adjusted so that the ultrasonic coupling layer 8 is located at a far-field position greater than 31 cm from the surface of the ultrasonic transducer 1 . The composition of other components and the connection mode between the components are the same as those in Embodiment 1.

Embodiment 3

[0045] The difference between embodiment 3 and embodiment 2 is that embodiment 3 provides the relationship between the ultrasonic far-field lengths of different transducer ceramic disc diameters and frequencies, as shown in Table 1.

[0046] Table 1 Ultrasonic far-field lengths of different transducer ceramic disc diameters and frequencies (unit: cm)

[0047]

[0048]

[0049] The change of sound intensity tends to be stable in the far field region, but with the increase of distance, the sound intensity gradually weakens. At this time, the length of the corrugated expander 5 can be adjusted so that the ultrasonic coupling layer 8 is taken to a place with a stronger sound field in the far field region.

[0050] The composition of other components and the connection mode between the components are the same as those in Embodiment 2.

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Abstract

The invention relates to a far-field ultrasonic probe for sonodynamic therapy, and belongs to the technical field of medical instruments. The ultrasonic probe comprises an ultrasonic transducer, an upper ultrasonic transmission cavity, electric displacement shafts, a corrugated expansion piece, a lower ultrasonic transmission cavity, an ultrasonic sound absorption layer and an ultrasonic coupling layer, wherein one end of the upper ultrasonic transmission cavity is fixedly connected with the ultrasonic transducer, and the other end of the upper ultrasonic transmission cavity is connected with one end of the corrugated expansion piece; the other end of the corrugated expansion piece is connected with one end of the lower ultrasonic transmission cavity; the ultrasonic coupling layer is fixed at the other end of the lower ultrasonic transmission cavity; the electric displacement shafts are distributed in four directions around the corrugated expansion piece serving as a center; the inner surface of the lower ultrasonic transmission cavity is coated with the ultrasonic sound absorption layer. The ultrasonic probe has the characteristics of simple structure, easiness in implementation, safety to use, high efficiency, high persistence and the like.

Description

technical field [0001] The invention relates to a far-field ultrasonic probe used for sonodynamic therapy, belonging to the technical field of medical instruments. Background technique [0002] Cardiovascular disease is the leading cause of human death, and atherosclerosis is its root cause. Bypass and stent treatment techniques are traumatic, and there are still many cases of postoperative restenosis. Acoustic dynamics based on ultrasonic excitation has been preliminarily proven to be a new method of non-invasive treatment of atherosclerosis. Acoustic dynamic therapy uses ultrasonic waves to have a strong ability to penetrate biological tissues, especially focused ultrasound can non-invasively transmit acoustic energy Focus on deep tissues and activate some sound-sensitive drugs (such as hematoporphyrin) to produce anti-tumor effects. Since there are more than one billion patients suffering from atherosclerosis in the world, and the sonodynamic treatment method is simple ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B8/00
CPCA61N7/00
Inventor 杨浩
Owner 杨浩
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