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Hydralazine nanoemulsion antihypertensive drug

An anti-hypertensive and hydralazine technology, applied in the field of medicine, can solve the problems that hydralazine cannot be used, the effect of hydralazine is slow, and the drug dissolution rate is slow, so as to maintain blood drug concentration and pharmacological effects, Effects of enhancing drug efficacy and improving bioavailability

Inactive Publication Date: 2016-11-16
张鸿利
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Existing antihypertensive drugs such as hydralazine tablet etc. on the market now, although can be absorbed from gastrointestinal tract after oral administration, but absorption is incomplete, and the dissolution rate of medicine is slow in addition, and bioavailability is extremely poor, and hydralazine Slow-acting, making the effects of hydralazine unavailable

Method used

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  • Hydralazine nanoemulsion antihypertensive drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049]32 g of EL40 and 4 g of ethanol were stirred uniformly at room temperature (25° C.), and then distilled water in which hydralazine was dissolved was slowly added dropwise thereto. With the increase of the amount of distilled water, the viscosity of the system increases. When the amount of distilled water is added to make the system change from water-in-oil to oil-in-water nanoemulsion, the viscosity of the system becomes thinner from the most viscous state. It is the colorless and transparent hydralazine nanoemulsion, and the amount of distilled water added at this time is 58g, and the amount of hydralazine is 6g. This ratio is the optimal ratio of hydralazine antihypertensive nanoemulsion.

[0050] Following example steps are with embodiment 1:

Embodiment 2

[0052] EL40 35g, 1,2-propanediol 5g, distilled water 55g, hydralazine 5g.

Embodiment 3

[0054] RH40 40g, glycerin 5g, distilled water 50.5g, hydralazine 4.5g.

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Abstract

The invention discloses an oil-in-water hydralazine nanoemulsion antihypertensive drug. The raw materials and the mass percentages of each raw material are: 1%-18% of hydralazine, 25%-45% of surfactant, and 25%-45% of surface active agent. The active agent is 0-20%, the remaining components are distilled water, and the sum of the mass percentages of the above-mentioned raw materials is 100%. The nano-emulsion droplet has small particles, uniform distribution, low viscosity and good fluidity. The nanoemulsion-type water-soluble drug hydralazine increases the stability and efficacy of hydralazine, significantly increases the antihypertensive effect, prolongs the half-life of the drug, and reduces the number of administrations.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new dosage form of an antihypertensive drug hydralazine, in particular to a hydralazine nanoemulsion antihypertensive drug. technical background [0002] Hydralazine, also known as hydralazine, is an antihypertensive drug that acts directly on the smooth muscle of arteries and arterioles. It reduces blood pressure by relaxing vascular smooth muscle and reducing peripheral resistance. Hydralazine has moderate-intensity hypotensive effect, which is characterized by a significant decrease in diastolic blood pressure and an increase in renal blood flow. Its antihypertensive effect begins to appear 30 to 40 minutes after administration. The antihypertensive effect is mainly to dilate the small arteries and reduce the total peripheral resistance, resulting in a drop in blood pressure. It is now mostly used in patients with renal hypertension and high diastolic blood pressure. The mechanism o...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/502A61K47/10A61K47/34A61P9/12
CPCA61K9/1075A61K31/502A61K47/10
Inventor 张鸿利
Owner 张鸿利
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