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Sea cucumber polysaccharide enteric-coated pellets and preparation method thereof

The technology of sea cucumber polysaccharide and enteric-coated pellets is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., and can solve the problems of low bioavailability of sea cucumber polysaccharides and instability of sea cucumber polysaccharides.

Active Publication Date: 2019-12-13
ZHEJIANG POLY PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, sea cucumber polysaccharides are unstable in the stomach and are easily degraded by gastric acid, resulting in low bioavailability of sea cucumber polysaccharides

Method used

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  • Sea cucumber polysaccharide enteric-coated pellets and preparation method thereof
  • Sea cucumber polysaccharide enteric-coated pellets and preparation method thereof
  • Sea cucumber polysaccharide enteric-coated pellets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Preparation of sea cucumber polysaccharide enteric-coated pellets:

[0020] The prescription for preparing sea cucumber polysaccharide enteric-coated micropills is as follows:

[0021]

[0022] Gown Prescription:

[0023]

[0024] Enteric coating formula:

[0025]

[0026] Preparation:

[0027] (1) Preparation of micropill pills: Mix sea cucumber polysaccharides, starch, and crospovidone evenly to obtain a mixture; dissolve povidone in 95% ethanol to prepare an adhesive; place the core of the pellet in In the centrifugal granulator, the mixture is powder-coated with a binder, and dried to obtain micropills after the drug-coating is completed;

[0028] (2) Prepare the isolation layer coating solution and enteric coating solution according to the prescription, then place the micropill pills in a centrifugal granulator, and coat with the isolation coating solution, and stop when the weight gain is 2%;

[0029] (3) Continue to coat the enteric-coated...

Embodiment 2

[0031] Embodiment 2: Micropills

[0032]

[0033] Isolation gown formula:

[0034]

[0035] Enteric coating formula:

[0036]

[0037] The preparation method is the same as in Example 1.

Embodiment 3

[0038] Embodiment 3: micropill pills

[0039]

[0040] Isolation gown formula:

[0041]

[0042] Enteric coating formula:

[0043] Udage L00 25 g triethyl citrate 5 g talcum powder 40 g ethanol 930g

[0044] The preparation method is the same as in Example 1.

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Abstract

The invention relates to sea cucumber polysaccharide enteric coating pellets and a preparing method thereof. The capsules comprise plain pellets formed after pellet cores are loaded with a sea cucumber polysaccharide mixed pharmaceutical adjunct, an isolating layer formed by wrapping of isolating layer coating fluid, and an enteric coating layer formed by wrapping of enteric layer coating fluid. The plain pellets are prepared from 30-60% of sea cucumber polysaccharide, 5-25% of pellet core, 0.5-1.5% of polyvinylpolypyrrolidone, 10-25% of starch, 1-5% of povidone, 10-30% of ethyl alcohol of 95%, and 1-10% of water. The sea cucumber polysaccharide enteric coating pellets are not dissolved in stomach and are dissolved and absorbed quickly in intestinal canal, and the situation that sea cucumber polysaccharide is degraded by gastric acid in stomach to affect the bioavailability of sea cucumber polysaccharide is avoided.

Description

technical field [0001] The invention relates to the field of deep processing of seafood, in particular to a sea cucumber polysaccharide enteric-coated pellet and a preparation method thereof. Background technique [0002] Sea cucumber belongs to the sea cucumber class. Modern scientific research has proved that every 100 grams of sea cucumber contains 15 grams of protein, 1 gram of fat, 0.4 grams of carbohydrates, 357 mg of calcium, 12 mg of phosphorus, 2.4 mg of iron, and vitamins B1, B2, niacin, Chondroitin sulfate, taurine, sea cucumber saponin and other ingredients have high nutritional value. Sea cucumber is not only a precious food material, but also a valuable medicinal herb. According to the records in "Compendium of Materia Medica": Sea cucumbers are sweet and salty in taste, nourish the kidneys, benefit the essence, take urine, aphrodisiac and treat fistulas. Modern studies have confirmed that sea cucumbers can delay aging, eliminate fatigue, improve immunity, pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/715A23L33/10
Inventor 范敏华
Owner ZHEJIANG POLY PHARMA