Application of mulberry particles to preparation of medicines for preventing and treating diabetes and complications thereof

A diabetes drug and complication technology, applied in the field of medicine, can solve the problems of too strong effect, aggravate the damage of heart and brain organs, and large changes in blood sugar level, and achieve the effect of improving cardiac dysfunction and inhibiting oxidative stress.

Active Publication Date: 2016-11-23
DAKANG JUNBISHA XIANYANG SHAANXI PROV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, although some chemical drugs have a certain effect on the complications in the treatment of diabetes, but because the effect is too strong, the blood sugar level in the body changes greatly, and it

Method used

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  • Application of mulberry particles to preparation of medicines for preventing and treating diabetes and complications thereof
  • Application of mulberry particles to preparation of medicines for preventing and treating diabetes and complications thereof
  • Application of mulberry particles to preparation of medicines for preventing and treating diabetes and complications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Effect of Mulberry Granules on Diabetic Blood Sugar, Blood Lipid and Insulin Levels

[0030] Mulberry granules were provided by Shaanxi Junbisha Pharmaceutical Co., Ltd. When used, it is prepared to the required concentration with physiological saline. The experimental animals were male C57BL / 6 mice, non-inbred closed group, weighing 23-25 ​​g, provided by the Experimental Animal Center of Fourth Military Medical University. The room temperature in the laboratory is 20-22°C, the relative humidity is 40%-60%, the ventilator is ventilated, the natural light source is 12h / day, and the cages are kept with 8 animals per cage. The cages are cleaned once every three days.

[0031] Mouse diabetes model: Adult C57BL / 6 mice were randomly divided into normal group and diabetes group, with 10 mice in each group; the normal group was fed normal diet, and the diabetes group was fed high-fat diet. After feeding for three weeks, fasting for 12 hours, the diabetic group was ...

Embodiment 2

[0036] Example 2: Effect of Sangshen Granules on Diabetes Complicated with Myocardial Ischemia-Reperfusion Injury

[0037] Mulberry granules were provided by Shaanxi Junbisha Pharmaceutical Co., Ltd. When used, it is prepared to the required concentration with physiological saline. The experimental animals were male C57BL / 6 diabetic mice, non-inbred closed group, weighing 23-25 ​​g, provided by the Experimental Animal Center of Fourth Military Medical University. The room temperature in the laboratory is 20-22°C, the relative humidity is 40%-60%, the ventilator is ventilated, the natural light source is 12h / day, and the cages are kept with 8 animals per cage. The cages are cleaned once every three days.

[0038] Diabetes combined with myocardial ischemia-reperfusion model: after intraperitoneal injection of 75mg / kg ketamine to anesthetize the mouse, fix the mouse on the mouse board in the supine position, cut off the neck hair, and make a longitudinal incision about 0.5cm in ...

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Abstract

The invention relates to application of mulberry particles to preparation of medicines for preventing and treating diabetes and complications thereof. The complications refer to one of cardiovascular diseases, cerebrovascular diseases, renal injuries and vascular injuries. The mulberry particles are especially excellent in prevention and treatment effect on cardiovascular disease complications of diabetes and particularly prominent in treatment effect on cardiac dysfunction, myocardial injuries or myocardial infarction caused by myocardial ischemia. Furthermore, the mulberry particles are effective in control of in-vivo blood sugar and blood lipid level of patients suffering from diabetes, capable of improving cardiac dysfunction caused by myocardial ischemia with diabetes and effective in inhibition of oxidative stress.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of mulberry granules in the preparation of medicines for preventing and treating diabetes and its complications. Background technique [0002] Mulberry, also known as mulberry, mulberry, mulberry, is the fruit of the Moraceae Morus mulberry (Morus alba L.) plant. The ripe fresh fruit flavor of mulberry is sweet and juicy, and it is one of the fruits that people often eat. There are about 16 species of this genus in the world, distributed in the northern temperate zone, tropical Asia, tropical Africa and the Americas. There are about 11 species in my country, which are distributed in most parts of the country, and the southern sericulture areas such as Jiangsu and Zhejiang have larger yields. Mulberry is rich in sugars, organic acids, lipids, vitamins, pigments, non-pigment phenols and minerals. In terms of medicinal effects, mulberry is sweet and cold in nature...

Claims

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Application Information

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IPC IPC(8): A61K36/605A61K9/16A61P3/10A61P13/12A61P9/00A61P9/10A61P9/06A61P9/04
CPCA61K9/16A61K36/605A61K2236/331A61K2236/39
Inventor 刘洋史志辉王四旺唐志书
Owner DAKANG JUNBISHA XIANYANG SHAANXI PROV
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