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Application of chaenomeles speciosa lauric anhydride to preparation of anti-hypertensive MF (myocardial fibrosis) drug

A technique for myocardial fibrosis and lauric anhydride, which is applied in the direction of anhydride/acid/halide active ingredients, drug combinations, cardiovascular system diseases, etc. , Improve the effect of cardiac structure and function damage

Inactive Publication Date: 2018-11-13
SOUTHERN MEDICAL UNIVERSITY
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Problems solved by technology

[0004] The purpose of the present invention is to provide the application of papaya lauric anhydride in the treatment of hypertensive myocardial fibrosis, the main active ingredient lauric anhydride extracted from papaya can be used to prepare antihypertensive myocardial fibrosis medicine, to solve the single antihypertensive way of western medicine and large side effects Provide a theoretical basis for the active ingredients of traditional Chinese medicine to lower blood pressure and improve myocardial fibrosis

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  • Application of chaenomeles speciosa lauric anhydride to preparation of anti-hypertensive MF (myocardial fibrosis) drug
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  • Application of chaenomeles speciosa lauric anhydride to preparation of anti-hypertensive MF (myocardial fibrosis) drug

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Embodiment 1

[0039] 1. Specific experimental steps

[0040] (1) Serum medicinal chemistry verification:

[0041] ① Ten 12-week-old male spontaneously hypertensive rats were randomly divided into 5 groups, including spontaneous hypertensive rat model group (spontaneous hypertensive rat, SHR) and SHR+papaya (chaenomeles speciosa, CS) group. The SHR+CS group was given the alcohol extract of papaya (Kangmei Chinese medicine decoction pieces, batch number 170551083) by intragastric administration, and the dosage was 4ml / kg, and the SHR was given the same amount of 0.9% normal saline by intragastric administration;

[0042] ②Continuous gavage for three days, and 3 hours after the last gavage, blood was collected from the tail vein with a 1ml syringe, and the plasma was left to stand at room temperature for 4 hours, then centrifuged at 3000r / min for 10min, and the serum was separated for later use;

[0043] ③Respectively take 0.5ml of serum from the SHR and SHR+CS groups, add 10μL of phosphoric ...

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Abstract

The invention discloses an application of chaenomeles speciosa lauric anhydride to preparation of an anti-hypertensive MF (myocardial fibrosis) drug, and belongs to the technical field of biomedicine.Chaenomeles speciosa lauric anhydride is used for treating an SHR (spontaneous hypertensive rat), after 12 weeks of medication, blood pressure of each SHR group is reduced, and content of serum endothelin of each dosage group of chaenomeles speciosa lauric anhydride is reduced remarkably; NO content is increased substantially; content of MCP-1, TNF-alpha, IL-1, IL-6, CRP and MDA can be reduced for each dosage group of chaenomeles speciosa lauric anhydride, which indicates that chaenomeles speciosa lauric anhydride can reduce content of inflammatory factors of myocardial tissue, reduce damageof oxidative stress to the tissue, further enhance oxidation resistance of the tissue and improve MF through multiple target points; echocardiography results show that cardiac function lesion caused by hypertensive MF can be improved effectively for a high dosage group of chaenomeles speciosa lauric anhydride.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of papaya lauric anhydride in the preparation of antihypertensive myocardial fibrosis drugs. Background technique [0002] Hypertension is a common disease that endangers the health of our people, and partial myocardial fibrosis (Myocardial Fibrosis, MF) is the main heart pathological change caused by hypertension, and it is also one of the important causes of various cardiovascular events. Therefore, it is of great significance to study the inhibition and reversal of myocardial fibrosis. On the other hand, hypertensive myocardial fibrosis is a more serious complication in the middle and late stage of hypertension. Different from simple hypertension and myocardial fibrosis caused by other reasons, conventional antihypertensive drugs and matrix metalloproteinase inhibitors cannot It can effectively improve myocardial fibrosis while lowering blood p...

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Application Information

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IPC IPC(8): A61K31/185A61P9/12A61P9/00
CPCA61K31/185A61P9/00A61P9/12
Inventor 张国华吕琳吴少瑜陈凯黄裕刘馨庄宇鑫管怡晴党文振马韵词
Owner SOUTHERN MEDICAL UNIVERSITY
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