Application of oltipraz in preparation of product for preventing and treating osteoporosis

A technology for osteoporosis and oltipraz, applied in the field of medicine, can solve the problems of prevention and treatment of osteoporosis that have not been reported yet, and achieve the effect of inhibiting osteoclast bone resorption and promoting osteoblast bone formation

Inactive Publication Date: 2021-06-18
南京医科大学友谊整形外科医院有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, experimental studies on oltipraz in the treatment of non-alcoholic fatty liver disease, hypoxic lung disease and diabetes have been carried out, but there are no reports on the prevention and treatment of osteoporosis with oltipraz

Method used

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  • Application of oltipraz in preparation of product for preventing and treating osteoporosis
  • Application of oltipraz in preparation of product for preventing and treating osteoporosis
  • Application of oltipraz in preparation of product for preventing and treating osteoporosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Example 1: Experimental verification that oltipraz has a preventive and therapeutic effect on osteoporosis caused by active vitamin D

[0076] 1. Oltipraz to 1,25(OH) 2 D deficient mice (1α(OH)ase + / - mouse) skeletal phenotype

[0077] 1.1 Oltipraz can correct bone mass loss caused by active vitamin D deficiency

[0078] Give WT and 1α(OH)ase after cage separation + / - Mice were fed a normal diet; given 1α(OH)ase + / - The mice were supplemented with oltipraz diet until they were 12 months old. The vertebral tissues of the mice were collected, and the differences in the vertebral phenotypes of the mice in each group were compared and analyzed by micro-CT scanning and histochemical methods.

[0079] Such as figure 1 The results showed that normal diet 1α(OH)ase + / - The bone mineral density, bone mass, bone trabecular thickness and number of mice were significantly reduced, and the separation degree of bone trabecula was significantly increased, while dietary supplemen...

Embodiment 2

[0106] Example 2: Experimental verification that oltipraz has a preventive and therapeutic effect on osteoporosis caused by estrogen deficiency

[0107] 1. The effect of oltipraz on the skeletal phenotype of estrogen-deficient mouse model

[0108] 1.1 The role of oltipraz in correcting osteoporosis caused by estrogen deficiency

[0109] Ovaryectomy (OVX) or sham operation (Sham) was performed on 2-month-old WT female mice, and OVX mice were given normal diet or oltipraz-supplemented diet at the same time, until 4-month-old, the vertebral tissues of the mice were collected and analyzed by micro-CT Scanning and histochemical staining methods were used to compare and analyze the differences in skeletal phenotypes of mice in each group.

[0110] Such as Figure 8 The results showed that compared with the sham operation group, the uterine weight and body weight of the mice in the OVX and OVX+oltipraz groups were significantly decreased, and the body weight was significantly incre...

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Abstract

The invention discloses an application of oltipraz in preparation of a product for preventing and treating osteoporosis. The application comprises any one of the following items: 1) preparing a product for preventing and treating osteoporosis caused by lack of active vitamin D; 2) preparing a product for preventing and treating osteoporosis caused by estrogen deficiency; and 3) preparing a product for preventing and treating osteoporosis caused by vitamin D receptor deficiency. According to the invention, through a test of supplementing an Nrf2 agonistoltiprazto a mouse model, the effect and related mechanism of oltipraz in preventing and treating osteoporosis caused by lack of active vitamin D are disclosed, and meanwhile, experimental and theoretical bases are provided for the application of oltipraz in preventing and treating osteoporosis caused by estrogen deficiency.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to the application of oltipraz in the preparation of products for preventing and treating osteoporosis. Background technique [0002] Osteoporosis (osteoporosis) is a systemic bone disease in which bone density and bone quality decrease due to various reasons, bone microstructure is destroyed, bone fragility increases, and fractures are prone to occur. Osteoporosis is divided into primary and secondary two categories. Primary osteoporosis is divided into three types: postmenopausal osteoporosis (type I), senile osteoporosis (type II) and idiopathic osteoporosis (including juvenile type). Postmenopausal osteoporosis generally occurs in women within 5 to 10 years after menopause; senile osteoporosis generally refers to the osteoporosis that occurs in the elderly after the age of 70; idiopathic osteoporosis mainly occurs in adolescents, and the etiology is still unknown . Osteoporosi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/497A61P19/10
CPCA61K31/497A61P19/10
Inventor 苗登顺张娇杨仁磊
Owner 南京医科大学友谊整形外科医院有限责任公司
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