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Traditional Chinese medicine composition having effect of reversing tumor multidrug resistance

A technology of multi-drug resistance and composition, which is applied in the direction of drug combination, antineoplastic drugs, pharmaceutical formulations, etc., to achieve the effect of reversing multi-drug resistance of tumors without toxic side effects

Inactive Publication Date: 2016-11-23
GUANGZHOU JIAYUAN PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese invention patent CN200710070320.4 discloses "the use of curcumin in the preparation of tumor multidrug resistance preventive agents", and Chinese invention patent CN200710143393.1 discloses "the application of artemisinin in the preparation of anti-tumor multidrug resistance drugs" Chinese invention patent CN1463701 discloses "bifendate as a new application of tumor multidrug resistance reversal agent"; Chinese invention patent CN102603692A discloses "an anti-tumor multidrug resistance inhibitor chroman and chromene derivatives and their Preparation method and application", Chinese invention patent CN101780068A discloses "Application of Leaforcin D in the preparation of anti-tumor drugs and anti-tumor multi-drug resistance reversal drugs", Chinese invention patent CN102274220A discloses "Sorafenib in the preparation of reverse tumor Application in drugs for multidrug resistance”; currently, the invention patents related to the preparation of tumor multidrug resistance reversal agents are basically concentrated on chemical drugs and traditional Chinese medicine monomer components, and there are basically no traditional Chinese medicine compositions combined with traditional Chinese medicine theory and clinical evaluation.

Method used

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  • Traditional Chinese medicine composition having effect of reversing tumor multidrug resistance

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Comparison scheme
Effect test

Embodiment 1

[0014] The preparation of embodiment 1 Chinese medicine composition of the present invention (taking ten times raw material proportioning amount as example)

[0015] 1. Weigh each API according to the following weight ratio

[0016] 100 grams of cloth-tailed dog, 100 grams of spring lotus, 100 grams of lily seeds, 50 grams of swan grass and 50 grams of honeycomb grass for later use.

[0017] 2. Mix the medicinal materials according to the above weight ratio, add 3 times the amount of water to soak for 1 hour, heat and decoct for 1.5 hours, filter, add 2 times the amount of water to the medicinal residue, heat and decoct for 1 hour, filter, combine the two filtrates, and let stand for 0.5 hour, pour out the supernatant; when the supernatant is concentrated to a relative density of 1.08, enter the spray dryer, the air inlet temperature is controlled at 120°C, the outlet air temperature is 105°C, the atomizer speed is 20 rpm, and the feed rate is 3ml / min to obtain 20 grams of sp...

Embodiment 2

[0018] The preparation of embodiment 2 Chinese medicine composition of the present invention (taking ten times raw material proportioning amount as example)

[0019] 1. Weigh each API according to the following weight ratio

[0020] 300 grams of cloth-tailed dog, 300 grams of spring lotus, 300 grams of lily seeds, 250 grams of chickweed and 250 grams of honeycomb grass for later use.

[0021] 2. Mix the medicinal materials according to the above weight ratio, add 3 times the amount of water to soak for 1 hour, heat and decoct for 1.5 hours, filter, add 2 times the amount of water to the medicinal residue, heat and decoct for 1 hour, filter, combine the two filtrates, and let stand for 0.5 pour out the supernatant; when the supernatant is concentrated to a relative density of 1.10, it enters the spray dryer, the inlet air temperature is controlled at 130°C, the outlet air temperature is 120°C, the atomizer speed is 30 rpm, and the feed rate is 5ml per minute to obtain 70 grams...

Embodiment 3

[0022] Embodiment 3 The preparation of Chinese medicine composition of the present invention (taking ten times raw material proportioning amount as example)

[0023] 1. Weigh each API according to the following weight ratio

[0024] 150 grams of cloth-tailed dog, 150 grams of spring lotus, 150 grams of lily seeds, 90 grams of chickweed and 90 grams of honeycomb grass for later use.

[0025] 2. Mix the medicinal materials according to the above weight ratio, add 3 times the amount of water to soak for 1 hour, heat and decoct for 1.5 hours, filter, add 2 times the amount of water to the medicinal residue, heat and decoct for 1 hour, filter, combine the two filtrates, and let stand for 0.5 hours, pour out the supernatant; when the supernatant is concentrated to a relative density of 1.09, enter the spray dryer, the inlet air temperature is controlled at 125°C, the outlet air temperature is 110°C, the atomizer speed is 25 rpm, and the feed rate is 4ml per minute to obtain 30 gram...

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Abstract

The invention discloses a traditional Chinese medicine composition having an effect of reversing tumor multidrug resistance and belongs to the field of traditional Chinese medicines. An active ingredient is manufactured by combining traditional Chinese medicines all-grass of longspike uraria, wusuli dragonflyorchis rhizome, lily seeds, myosoton aquaticum and leucas zeylanica as raw materials.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for reversing tumor multidrug resistance, which belongs to the field of traditional Chinese medicines. technical background [0002] Malignant tumor is a major disease that seriously affects human health. Chemotherapy is still one of the important methods for treating malignant tumors. However, in clinical practice, there are often problems such as insensitivity to chemotherapy or poor chemotherapy effect, or some tumors are still sensitive to chemotherapy at the initial stage. However, drug resistance occurs during chemotherapy, and these cases often have tumor metastasis and recurrence after surgical treatment, and eventually lead to death. Multidrug resistance (MDR) of tumor cells to anti-tumor drugs is a common factor leading to the failure of tumor chemotherapy. A variety of antineoplastic drugs with different structures, irrelevant structures and different mechanisms also have c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P35/00
CPCA61K36/898A61K36/36A61K36/48A61K36/53A61K36/8967A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 王素侠王琦
Owner GUANGZHOU JIAYUAN PHARMA TECH
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