Monocyclic gyrase and topoisomerase IV inhibitors

A stereoisomer, selected technology, applied in the field of medicine, can solve the problems of poor bacterial outer membrane penetration, poor solubility, and no clinical application
CN106167486BActive Publication Date: 2019-06-14BEIJING SIHUAN PHARMA
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
BEIJING SIHUAN PHARMA
Publication Date
2019-06-14

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Abstract

The invention belongs to the technical field of medicines, and in particular relates to a gyrase and topoisomerase IV inhibitor compound of formula (I) as shown in the specification, and a pharmaceutically acceptable salt, an ester or stereoisomers thereof. In the formula, R1, R2, R3 and cycle A are defined as in the specification. The invention further relates to preparation methods, medicinal preparations, medicinal compositions and applications of the compounds in preparing medicines for treating and / preventing bacterium infectious diseases.
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Description

1. Technical field

[0001] The invention belongs to the field of medical technology, and specifically relates to gyrase and topoisomerase IV dual-target inhibitor compounds, pharmaceutically acceptable salts, esters or stereoisomers thereof; the invention also relates to preparation methods of these compounds, Pharmaceutical preparations, pharmaceutical compositions and applications in the preparation of medicines for treating and / preventing bacterial infectious diseases. 2. Background technology

[0002] With the extensive use of antibiotics, especially non-indication use, inappropriate selection of backup antimicrobials, overtreatment and frequent replacement of antibiotics, the frequency of bacterial resistance to drugs is increasing. In particular, the emergence of some specific bacterial strains, such as: Streptococcus pneumoniae, Mycobacterium tuberculosis and Enterococcus, have made various clinically widely used antibiotics ineffective to varying degrees. Therefore, t...

Claims

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