Pycyclic gyrase and topoisomerase iv inhibitors

A stereoisomer, heterocyclic group technology, applied in the direction of anti-inflammatory agents, non-central analgesics, medical preparations containing active ingredients, etc., can solve the problem of poor solubility, poor bacterial outer membrane penetration, and no clinical application and other issues
CN105884752BActive Publication Date: 2018-08-31BEIJING SIHUAN PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BEIJING SIHUAN PHARMA
Publication Date
2018-08-31

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Abstract

The invention belongs to the technical field of medicament, and particularly relates to a compound shown in formula (I) (please see the formula (I) in the description), and acceptable salt, ester or stereoisomer of the compound in pharmacy. R1, R2, a ring A and a ring B are defined in the description. The invention further relates to a preparation method, pharmaceutical preparations and pharmaceutical compositions of the compounds, and application of the compounds in preparation of medicines for treating and preventing bacterial infectious diseases.
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Description

1. Technical field

[0001] The present invention belongs to the technical field of medicine, and in particular relates to a dual inhibitor compound of gyrase and topoisomerase IV, a pharmaceutically acceptable salt, ester or stereoisomer thereof; the present invention also relates to a preparation method of these compounds, Pharmaceutical preparations, pharmaceutical compositions and uses in the preparation of medicines for treating and / or preventing bacterial infectious diseases. 2. Background technology

[0002] With the extensive use of antibiotics, especially non-indication use, inappropriate selection of backup antimicrobials, overtreatment and frequent replacement of antibiotics, the frequency of bacterial resistance to drugs is increasing. In particular, the emergence of some specific bacterial strains, such as: Streptococcus pneumoniae, Mycobacterium tuberculosis and Enterococcus, have made various clinically widely used antibiotics ineffective to varying degrees. The...

Claims

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