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Pharmaceutical composition for external use

A technology for externally used drugs and compositions, which is applied in the direction of drug combinations, antineoplastic drugs, and pharmaceutical formulations, and can solve the problems that there are no reports on the combined use of timolol and allantoin, so as to overcome the problems of adverse reactions, Increased transdermal absorption, good soothing and soothing effects

Active Publication Date: 2016-12-07
BEIJING MERSON PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] In the currently published literature, there is no report on the combined use of timolol and allantoin

Method used

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  • Pharmaceutical composition for external use
  • Pharmaceutical composition for external use
  • Pharmaceutical composition for external use

Examples

Experimental program
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Effect test

Embodiment 1

[0047]

[0048] Preparation process: Heat the oily and oil-soluble components (liquid paraffin, stearic acid, glyceryl monostearate) in the prescription together to about 80°C to form an oil solution (oil phase), and add the water-soluble components (glycerin , sodium hydroxide) dissolved in water and heated together to 80 ° C to form an aqueous solution (water phase). When the oil phase is mixed with the water phase, add the water phase to the oil phase. After stirring for 30 minutes, add timolol maleate, allantoin and ethylparaben in sequence, continue stirring for 30 minutes, and cool to room temperature under stirring to obtain timolol maleate cream.

Embodiment 2

[0050]

[0051] Preparation process: Heat the oily and oil-soluble components (methicone, stearic acid, cetostearyl alcohol) in the prescription together to about 75°C to form an oil solution (oil phase), and add the water-soluble components (horse Timolol toate, propylene glycol, allantoin, glycerol macrogol-75-stearate, ethylparaben) are dissolved in water and heated together to 70°C to form an aqueous solution (water phase). When the oil phase is mixed with the water phase, stir for 30 minutes, and then cool to room temperature under stirring to obtain timolol maleate cream.

Embodiment 3

[0053]

[0054] Preparation process: Heat the oily and oil-soluble components (liquid paraffin) in the prescription to about 30°C to form an oil solution (oil phase), and add water-soluble components (HPMC, timolol maleate, propylene glycol, urine Blastosin, polysorbate 80, methylparaben / propyl ester) are dissolved in water and heated together to 30°C to form an aqueous solution (water phase). The oil phase is mixed with the water phase, and after stirring for 30 minutes, timolol maleate cream is obtained.

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Abstract

The invention relates to a pharmaceutical composition for external use. The pharmaceutical composition is characterized by simultaneously containing timolol and allantoin, wherein, timolol can be a free alkali form, and also can be an any pharmaceutically acceptable salt form. The composition preparation has good stability and permeability, and has obvious curative effect for infantile hemangioma.

Description

technical field [0001] The present invention relates to a pharmaceutical composition comprising timolol and allantoin, more particularly a compound external cream or gel of timolol hydrochloride, timolol maleate and allantoin . Background technique [0002] Infantile hemangioma (IH) is the most common benign tumor in childhood, with an incidence rate of 10%-12% in newborns, and a male-to-female ratio of 1:3-1:5. It is usually divided into superficial type, deep type, and mixed type according to the location of the lesion; according to the development process of the lesion, it is divided into a proliferative phase, a regression phase, and a regression completion phase. The typical clinical manifestation of infantile hemangioma is rapid proliferation within 1 year after birth, and then gradually subsides slowly. [0003] Although hemangiomas in infants and young children can subside on their own, about 10% of the children still have serious complications such as ulcers, infe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5377A61K9/06A61P35/00A61P9/00A61K31/4166
CPCA61K9/06A61K31/4166A61K31/5377A61K47/32A61K47/38A61K47/44A61K2300/00
Inventor 赵锡龙李银博林秀
Owner BEIJING MERSON PHARMA CO LTD
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