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Applications of discolor cinquefoil herb triterpenoid in treating diabetes mellitus

A technology of Herba Vermiliae and its compound, which is applied in the field of application of Triterpenoids Triterpene Compounds in the treatment of diabetes, and can solve the problems of less systematic research on Herba Vernis

Active Publication Date: 2016-12-07
SHANGHAI TRADITIONAL CHINESE MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the domestic and foreign researches on Herba Vermiliae focus on the evaluation of the curative effect of a single link. There are few systematic studies on the chemical components, separation and extraction, pharmacological activity, and material basis of medicinal effects of Herba Vernis Herba.

Method used

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  • Applications of discolor cinquefoil herb triterpenoid in treating diabetes mellitus
  • Applications of discolor cinquefoil herb triterpenoid in treating diabetes mellitus
  • Applications of discolor cinquefoil herb triterpenoid in treating diabetes mellitus

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0013] (1) Extraction of compounds

[0014] 1. Experimental method

[0015] 1.1 Experimental instruments and materials

[0016] Melting point was measured with X-4 binocular microscopic melting point tester (uncorrected temperature, manufactured by Beijing Tektronix Instrument Co., Ltd.); UV was measured with Shimadzu UV-2501PC visible-ultraviolet spectrophotometer; NMR: Bruker AV-500 Nuclear magnetic resonance apparatus, δ is ppm, J is Hz.

[0017] Thin layer chromatography silica gel H, thin layer chromatography silica gel GF 254 , column chromatography silica gel (100-200 mesh, 200-300 mesh, Qingdao Ocean Chemical Factory); ODS column (40-60 μm, Fuji), Sephadex LH-20 dextran gel (purchased from Pharmacia company); MCI column (Mitsubishi Chemical Corporation, Japan).

[0018] All reagents used were of analytical grade.

[0019] 1.2 Plant source

[0020] The medicinal material of Potentilla discolor Bunge was collected from Guangxi. The plant specimen was identified as ...

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Abstract

The invention provides a triterpenoid shown as the formula (I). The triterpenoid has the applications of being prepared into medicines for treating diabetes mellitus type 2. The formula (I) is shown in the description.

Description

technical field [0001] The invention relates to a triterpene compound of panbacao and its application in treating diabetes. Background technique [0002] Potentilla discolor Bunge, a traditional Chinese medicine, is the dried whole herb of Potentilla discolor Bunge in the Rosaceae family. Fenbacao is widely distributed in the temperate and frigid zones of the northern hemisphere. In my country, Shandong, Liaoning, and Anhui have the largest production of this medicinal material. In addition, it is also distributed in Hebei, Henan, Inner Mongolia, Hunan, Jiangsu, and Guangxi. Its nature is sweet, bitter, and flat, and has the effects of clearing heat and detoxification, stopping bleeding and reducing swelling, and can be used to treat dysentery, malaria, lung abscess and other diseases. [0003] At present, domestic and foreign researches on Herba Vermiliae focus on the evaluation of the curative effect of a single link. There are few systematic studies on the chemical const...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P3/10C07J63/00
CPCA61K31/56A61K36/73C07J63/008
Inventor 谈景福朱光明俞磊明朱俊杰王立会
Owner SHANGHAI TRADITIONAL CHINESE MEDICINE CO LTD