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High-flux chip processing and analysis flow control method for long-chain non-coding RNA

A long-chain non-coding, process control technology, applied in the direction of electrical digital data processing, special data processing applications, instruments, etc., can solve the problems of long-chain non-coding RNA high-throughput chip data processing inaccuracy, incomprehensible analysis, etc. , to achieve the effect of optimizing working time, wide application range and simple realization method

Inactive Publication Date: 2016-12-07
SOUTHEAST UNIV
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Problems solved by technology

[0003] The purpose of the present invention is to provide a long-chain non-coding RNA high-throughput chip data processing and analysis process control method to solve the inaccuracy of the existing technology in the long-chain non-coding RNA high-throughput chip data processing, and Do not know how to analyze long non-coding RNA and other issues

Method used

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Embodiment

[0097] Firstly, the original data is filtered, and then the low-quality signal and noise-contaminated data are removed, and the effective long-chain non-coding RNA expression value is obtained after normalization. Based on the analysis results of long-chain non-coding RNA, the target gene can be predicted based on its sequence characteristics; the function prediction can also be combined with the co-expressed gene expression profile. Long noncoding RNA-coexpressed gene networks such as image 3 shown. On the basis of the above analysis, a series of statistical and visual analysis can be carried out.

[0098] 1. The original signal file of long non-coding RNA is shown in Table 1

[0099] Analysis platform: R platform

[0100] Analysis software: Affy, limma

[0101] Table 1

[0102]

[0103] Explanation of column names:

[0104]

[0105] 2. The expression results of the long-chain non-coding RNA chip are shown in Table 2

[0106] Analysis platform: R platform

[01...

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Abstract

The invention discloses a high-flux chip processing and analysis flow control method for long-chain non-coding RNA. Firstly, a system generates a self-defined parameter configuration file, and a batch processing executable file corresponding to data flow is generated according to a self-defined parameter file obtained after parameters are set by a user and a high-flux chip data processing flow module; the system executes the batch processing executable file to achieve data flow automation, and finally a result report file is generated. Biological information analysts can be efficiently assisted in completing a set of standardized high-flux data analysis flow, and scientific research personnel major in the non-biological information specialty can independently complete high-flux data analysis. The purposes of optimizing the working efficiency of the scientific research personnel and reducing the scientific research cost are achieved. A reliable analysis method for multiple kinds of long chain non-coding RNA is provided, the method can be used for high-flux data analysis of non-coding RNA of other types, and is universal in different varieties of fields, the implementation method is simple, and the application range is wide.

Description

technical field [0001] The invention relates to the fields of medical genomics and computational biology, in particular to a high-throughput chip data processing and analysis process control method for long-chain non-coding RNA. Background technique [0002] Long non-coding RNA (long non-coding RNA, lncRNA) is a type of RNA whose transcript length exceeds 200nt and does not encode proteins. Long non-coding RNAs were originally considered to be the "noise" of genome transcription and have no biological function. However, recent studies have shown that long non-coding RNAs can regulate gene expression at the epigenetic, transcriptional and post-transcriptional levels, and participate in X chromosome silencing, genomic imprinting and chromatin modification, transcriptional activation, transcriptional interference, and nuclear transport Many other important regulatory processes are closely related to the occurrence, development and prevention of human diseases. Long non-coding...

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Application Information

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IPC IPC(8): G06F19/20G06F19/24
CPCG16B40/00G16B25/00
Inventor 陈瑞高娜李晓波孟庆涛吴申申
Owner SOUTHEAST UNIV
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