Unlock instant, AI-driven research and patent intelligence for your innovation.

Soybean lecithin liposome and preparation method thereof

A soy lecithin and liposome technology, applied in the field of soy lecithin liposome and its preparation, can solve the problems of inability to eradicate toxicity, high encapsulation rate and leakage rate, and achieve enhanced stability, improved encapsulation rate, and improved particle size. Effects of uniformity and roundness

Inactive Publication Date: 2016-12-14
铜陵翔宇商贸有限公司
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is that the existing soybean lecithin liposome and its preparation method have toxicity that cannot be eradicated, and the encapsulation rate and leakage rate are relatively high. Therefore, a soybean lecithin liposome and its preparation method are provided

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: soybean lecithin liposome, it comprises by weight: 10 parts of soybean lecithin, 4 parts of cholesterol, 20 parts of dehydrated alcohol, 0.2 part of disodium hydrogen phosphate, 0.4 part of sodium dihydrogen phosphate, 5 parts of agar, 6 parts titanium dioxide and 100 parts deionized water.

[0013] The preparation method of soybean phospholipid liposome comprises the following steps: adding 0.2 parts of disodium hydrogen phosphate and 0.4 parts of sodium dihydrogen phosphate to 1 / 3 of the total amount of deionized water to dissolve, heating to 40°C for 10 minutes, adding 5 parts of Agar was heated to 70-80°C at a rate of 2°C / min to form a suspension; 10 parts of soybean lecithin, 4 parts of cholesterol and 20 parts of absolute ethanol were mixed, placed in a 55°C water bath and stirred for 4 minutes to form a mixed solution. Put 6 parts of titanium dioxide, the mixed solution and the remaining amount of deionized water into the reactor and rotate and stir...

Embodiment 2

[0014] Embodiment 2: soybean lecithin liposome, it comprises by weight: 15 parts of soybean lecithin, 6 parts of cholesterol, 30 parts of dehydrated alcohol, 0.3 part of disodium hydrogen phosphate, 0.5 part of sodium dihydrogen phosphate, 7 parts of agar, 8 parts titanium dioxide and 120 parts deionized water.

[0015] The preparation method of soybean phospholipid liposome comprises the following steps: adding 0.3 part of disodium hydrogen phosphate and 0.5 part of sodium dihydrogen phosphate into 1 / 3 of the total amount of deionized water to dissolve, heating to 50°C for 15 minutes, adding 7 parts of Agar was heated to 75°C at a speed of 3°C / min to form a suspension; 15 parts of soy lecithin, 6 parts of cholesterol and 30 parts of absolute ethanol were mixed, placed in a 60°C water bath and stirred for hydration for 6 minutes to form a mixed solution, and 8 Parts of titanium dioxide, the mixed solution and the remaining amount of deionized water were put into the reactor an...

Embodiment 3

[0016] Embodiment 3: soybean lecithin liposome, it comprises by weight: 20 parts of soybean lecithin, 8 parts of cholesterol, 40 parts of dehydrated alcohol, 0.4 part of disodium hydrogen phosphate, 0.6 part of sodium dihydrogen phosphate, 9 parts of agar, 10 parts titanium dioxide and 140 parts deionized water.

[0017] The preparation method of soybean phospholipid liposome comprises the following steps: adding 0.4 parts of disodium hydrogen phosphate and 0.6 parts of sodium dihydrogen phosphate to 1 / 3 of the total amount of deionized water to dissolve, heating to 60 ° C for 20 minutes, adding 9 parts of Agar was heated to 80°C at a rate of 4°C / min to form a suspension; 20 parts of soy lecithin, 8 parts of cholesterol and 40 parts of absolute ethanol were mixed, placed in a 65°C water bath and stirred for hydration for 8 minutes to form a mixed solution, and 10 Parts of titanium dioxide, the mixed solution and the remaining amount of deionized water were put into the reactor...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a soybean lecithin liposome and a preparation method thereof. The soybean lecithin liposome comprises the following components in parts by weight: 10-20 parts of soybean lecithin, 4-8 parts of cholesterol, 20-40 parts of anhydrous alcohol, 0.2-0.4 part of disodium hydrogen phosphate, 0.4-0.6 part of sodium dihydrogen phosphate, 5-9 parts of agar, 6-10 parts of titanium dioxide and 100-140 parts of deionized water. The soybean lecithin liposome has the beneficial effects that the agar is added in a buffering solution to improve the stability of the buffering solution, titanium dioxide is added to improve the particle uniformity and roundness of the prepared liposome particles, the leakage rate can be reduced while the encapsulation efficiency can be improved, and the soybean lecithin liposome is applicable to encapsulation of various water-soluble medicines.

Description

technical field [0001] The invention relates to the field of preparation of medical drug carriers, in particular to soybean lecithin liposome and its preparation method. Background technique [0002] Liposome is a spherical vesicle with a bimolecular membrane formed by phospholipid molecules in water. It has a structure similar to that of a cell membrane, so it has good biocompatibility. By incorporating some targeting substances into the liposome membrane, liposomes can be targeted and concentrated at specific sites. Therefore, in recent years, liposomes have been widely used in the research of drug carriers. The main materials of liposomes are synthetic phospholipids. and natural phospholipids. Synthetic phospholipids are expensive and generally only available in research. Natural phospholipids include soybean phospholipids and egg yolk phospholipids. Among them, soybean lecithin has a high fatty acid content and a high degree of unsaturation in the fatty chain. Liposome...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/127A61K47/24A61K47/28A61K47/02A61K47/36
CPCA61K9/1277A61K47/02A61K47/24A61K47/28A61K47/36
Inventor 沙以仙
Owner 铜陵翔宇商贸有限公司