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Medical bone wound hemostatic material and preparation method thereof

A hemostatic material and wound surface technology, applied in the field of medicine, can solve the problems of poor viscosity, fineness, plasticity and hemostatic effect, bacterial infection and rejection, permanent foreign body retention, etc. good effect

Active Publication Date: 2016-12-14
杭州中科理化生物医药技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether it is the bone wax produced by the hospital itself or the bone wax developed by Johnson & Johnson and the General Hospital of Shenyang Military Region, although they can achieve hemostatic effect, they are all non-degradable and remain in the human body as a permanent foreign body. Complications such as bone nonunion, bacterial infection, and rejection occur; and when medical sterile bone paste is applied to the oozing bone wound or pasted on the bleeding bone, it is prone to dryness, cracking, non-softening, inability to smear or non-sticking and falling off after smearing phenomenon
[0003] It is clinically required that bone wound hemostatic materials have many characteristics such as suitable viscosity, fineness, toughness, high melting point, random plasticity, and acceptable pressure at room temperature. According to the clinical requirements for bone wound hemostasis, currently clinical The bone wax formula used is prepared with beeswax as the main raw material, which is not good in viscosity, fineness, plasticity and hemostatic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] First, use ethylene oxide to sterilize the gelatin and hydroxyapatite; add 1 g of sterilized gelatin and 5 ml of high-pressure steam-sterilized distilled water into a high-pressure steam sterilized container, and then stir in a constant temperature water bath at 55°C Until it dissolves and cools to obtain a gelatin solution; add 1 g of sterilized hydroxyapatite to the solution, the particle size of the hydroxyapatite is 200 nm, and then sterilize the glass with high pressure steam at 55 ° C The stick was stirred for 1 hour to obtain a medical bone wound hemostatic material.

Embodiment 2

[0025] First utilize ethylene oxide to sterilize chitosan, collagen peptide and tricalcium phosphate; add 0.1g sterilized chitosan, 0.8g sterilized collagen peptide and The distilled water of 5ml high-pressure steam sterilization is then stirred in the constant temperature water bath of 55 ℃ until dissolving, after cooling, the solution containing chitosan and collagen peptide is obtained; in the solution, add tricalcium phosphate after 10g sterilization, the The particle size of tricalcium phosphate is 900nm, and then stirred with a high-pressure steam sterilized glass rod for 5 hours at 55°C to obtain a medical hemostatic material for bone wounds.

Embodiment 3

[0026] Example 3 Effects on the Hemostatic Effect and Wound Healing of Rabbit's Ilium Wound

[0027] 1. Experimental method: 48 healthy adult rabbits were used, with a body weight of 1.9-2.6kg, with an average of 2.25±0.38kg; the rabbits were randomly divided into 4 groups, 12 in each group, respectively A group and B group , Group C, and Group D, and randomly selected the left and right sides of the ilium bone defect model of rabbits in each group; the rabbits in group A used medical bone wound hemostatic materials, the rabbits in group B used absorbable gelatin sponge, and the rabbits in group C Rabbits were treated with ordinary bone wax, and rabbits in group D were used as blank control group.

[0028] Before the operation, fasting without food and water, using pentobarbital sodium anesthetics for intravenous anesthesia, the volume concentration of normal saline used is 2%, and the rabbits are injected with pentobarbital sodium along the ear vein according to the body weig...

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Abstract

The invention discloses a medical bone wound hemostatic material. The bone wound hemostatic material is composed of the following raw materials by mass percent: 5-80% of sterilized biopolymer and 20-95% of medical calcium salt. The invention also discloses a preparation method for the medical bone wound hemostatic material. The medical bone wound hemostatic material prepared according to the method provided by the invention has the advantages of high plasticity, moderate plasticity, fine hand feeling, no local stimulation, excellent plasticity, performance safety, convenience in use and long-term storage. The medical bone wound hemostatic material provided by the invention can quickly stop bleeding in a practical application, has a function of promoting curing, is capable of increasing the wound healing effect and can prevent inflammation, edema and necrosis from happening. The medical bone wound hemostatic material can be widely used for stopping bleeding for the cavum medullare section and the bone section in craniotomy, thoracotomy and orthopedic surgery.

Description

technical field [0001] The invention belongs to the technical field of medicine. Specifically, it relates to a medical bone wound hemostatic material and a preparation method thereof. Background technique [0002] Medical sterile bone wax is an essential auxiliary material for hemostasis on osteoporotic sections in orthopedics, cardiovascular surgery, and craniocerebral surgery. It mainly relies on its unique hardness, toughness, viscosity, and mechanical packing to achieve the purpose of hemostasis. At present, beeswax, petroleum jelly, refined sesame oil and salicylic acid are mostly used to prepare. The hemostatic effect is acceptable. The main products in the domestic market are the medical bone wax produced by Johnson & Johnson in the United States, and the medical sterile bone wax (patent No. 00110393.8) developed by my country's Shenyang Military Region General Hospital was approved by SFDA in 2003. However, whether it is the bone wax produced by the hospital itsel...

Claims

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Application Information

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IPC IPC(8): A61L24/00A61L24/02A61L24/10A61L24/08
CPCA61L24/0005A61L24/001A61L24/0015A61L24/0042A61L24/02A61L24/08A61L24/102A61L24/104A61L2300/232A61L2300/252A61L2300/404A61L2300/412A61L2400/04C08L5/08
Inventor 韦淑玲吴珊
Owner 杭州中科理化生物医药技术有限公司
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