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Preparation method of ferrous sulfate enteric-coated dropping pills

A ferrous sulfate enteric-coated dripping technology, applied in sugar-coated pills, pill delivery, pharmaceutical formulations, etc., can solve the problem of not producing ferrous sulfate enteric-coated dripping pills, etc., and achieves convenient taking and carrying, fast onset of action, and appearance. good quality effect

Active Publication Date: 2019-07-19
GUANGXI UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] At present, the dosage form of ferrous sulfate enteric-coated dripping pills has not been produced at home and abroad, and there are almost no related reports.

Method used

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  • Preparation method of ferrous sulfate enteric-coated dropping pills
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  • Preparation method of ferrous sulfate enteric-coated dropping pills

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A preparation method for ferrous sulfate enteric-coated dripping pills, which comprises the following steps:

[0039] (1) Preparation of ball core: weigh the composite matrix and FeSO at a weight ratio of 3:1 4 ·7H 2 O, the composite matrix is ​​a mixture of PEG6000 and PEG4000, the weight ratio of PEG6000 and PEG4000 is 1:4, mix PEG6000 and PEG4000 and heat to 70°C, then mix the composite matrix with FeSO 4 ·7H 2 O melts at this temperature, fully stirs, mixes evenly, obtains the medicinal liquid, keeps warm for 20min, then draws the medicinal liquid and drips it into the condensate under the conditions of a drop distance of 2cm and a drip speed of 10 drops / min, forms a pill, and stands for half a day. Take it out after one hour, wipe off the condensate, and dry it; the temperature of the lower half of the condensate is 0°C, and the condensate is paraffin;

[0040] (2) Preparation of enteric film coating solution: Soak acrylic resin No. II in an ethanol solution wit...

Embodiment 2

[0043] A preparation method for ferrous sulfate enteric-coated dripping pills, which comprises the following steps:

[0044] (1) Preparation of pellet core: weigh the composite matrix and FeSO at a weight ratio of 4:1 4 ·7H 2 O, the composite matrix is ​​a mixture of PEG6000 and PEG4000, the weight ratio of PEG6000 and PEG4000 is 4:1, mix PEG6000 and PEG4000 and heat to 85 °C, then mix the composite matrix with FeSO 4 ·7H 2 O melts at this temperature, fully stirs, mixes evenly, obtains medicinal liquid, heat preservation 20min, draws medicinal liquid again and drips in the condensed liquid under the condition of drop distance 4cm, dripping speed 35 drops / min, forms pill, stands halfway Take it out after an hour, wipe off the condensate, and dry it; the temperature of the lower half of the condensate is 10°C, and the condensate is paraffin;

[0045] (2) Preparation of enteric film coating solution: Soak acrylic resin No. II in an ethanol solution with a mass content of 85% ...

Embodiment 3

[0048] A preparation method for ferrous sulfate enteric-coated dripping pills, which comprises the following steps:

[0049] (1) Preparation of pellet core: weigh the composite matrix and FeSO at a weight ratio of 5:1 4 ·7H 2 O, the composite matrix is ​​a mixture of PEG6000 and PEG4000, the weight ratio of PEG6000 and PEG4000 is 2:1, mix PEG6000 and PEG4000 and heat to 90 °C, then mix the composite matrix with FeSO 4 ·7H 2 O melts at this temperature, fully stirs, mixes evenly, obtains medicinal liquid, heat preservation 20min, draws medicinal liquid again and drips in the condensed liquid under the condition of drop distance 6cm, dripping speed 50 drops / min, forms pill, stands for half Take it out after an hour, wipe off the condensate, and dry it to get it; the temperature of the lower half of the condensate is 20°C, and the condensate is paraffin;

[0050] (2) Preparation of enteric film coating solution: Soak acrylic resin No. II in an ethanol solution with a mass cont...

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Abstract

The invention discloses a preparation method of ferrous sulfate enteric-coated dropping pills, which comprises the following steps: (1) preparation of pill cores (2) preparation of enteric film coating liquid; (3) coating to obtain sulfuric acid Ferrous enteric-coated drop pills. The ferrous sulfate enteric-coated dropping pills produced by the present invention have small weight difference, high roundness, long dissolution time limit and good appearance quality, and all meet the requirements of the 2010 edition of the Chinese Pharmacopoeia.

Description

technical field [0001] The invention belongs to the field of medicine preparation, and in particular relates to a preparation method of ferrous sulfate enteric-coated dripping pills. Background technique [0002] At present, iron is an essential trace element for the human body. The body is highly dependent on iron, and iron deficiency is a nutritional problem I often encounter. Iron deficiency is the most inevitable problem in both developed and developing countries. The amount of iron in the human body is not much, accounting for about 4 / 100,000 of the body weight, and the iron content in the adult body is about 3-5 grams. According to the chemical properties and the role of iron in the body, it is divided into functional iron and reserve iron. Although their storage methods and proportions are different, their functions in the body are generally the same. Among the trace elements, the body's demand for iron is Other elements are irreplaceable and also an indispensable ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/32A61K33/26A61P3/02A61P7/06
CPCA61K9/284A61K33/26
Inventor 韦媛媛陈晓伟郭莎莎龙圣亿
Owner GUANGXI UNIVERSITY OF TECHNOLOGY
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