Blank high-molecular microspheres and preparation method thereof

Abstract

The invention provides blank high-molecular microspheres prepared by a spray drying method. With use of the instant drying ability of spray drying and the excellent dissolving ability of dichloromethane and the like, a high-molecular material is made into the microspheres. Through the characterization observation and particle size determination of the microspheres, the diameter size and surface appearance of a slow-release carrier support material are known, and the diameter of the blank high-molecular microspheres is in line with the size for injection. Compared with other microsphere preparation methods, the spray drying method is simple, the repetition rate is high, and the structure of the microspheres is clear. Animal in-vivo pharmacokinetics and in-vitro release degree evaluation show that the microsphere carrier is used as a good sustained-release carrier for different treatment drugs in the field of drug sustained or controlled release.

Description

technical field [0001] The invention belongs to a slow-release drug carrier skeleton material, relates to a spray-drying conversion method for a slow-release material, in particular to a polymer microsphere and a preparation method. Background technique [0002] Biodegradable long-acting sustained-release microspheres are a new type of drug delivery system developed in recent decades, and microsphere preparations have become a hot topic in the study of sustained-release preparations. After the drug is made into a microsphere preparation, it can mask the bad smell of the drug and improve the compliance of the patient with medication. The drug-loaded microspheres also have the characteristics of slow dissolution and release and directional implantation. They can be passively or actively concentrated in the target organ, and release the drug stably for a long time to maintain the concentration of the local drug, which greatly reduces the dosage. Prolonging the action time of t...

AI Technical Summary

Problems solved by technology

[0006] The production conditions of the above-mentioned microsphere preparation method are too complicated, and factors such as temperature, pH value, and addition of electrolytes need to be controlled to prepare microspheres or microcapsules that meet the requirements.

Chemical methods and physical chemical methods can generally be carried out through reactors. Although they are widely used, it is difficult to achieve large-scale production.

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