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Brucea javanica oil emulsion, preparation method and application

A technology of javanica javanica oil emulsion and javanica javanica oil, which is applied in the direction of medical formula, emulsion delivery, and medical preparations of non-active ingredients, etc., can solve the problems of high price, no contribution to therapeutic effect, large usage, etc., and achieve large Application development prospect, excellent anti-tumor effect

Active Publication Date: 2019-04-30
GANSU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the main dosage form of javanica javanica oil as an injection is javanica javanica oil emulsion, and its auxiliary materials are mainly soy lecithin and glycerin. The ingredient is javanica javanica oil, and the role of excipients is only to maintain the stability of the dosage form, and does not contribute to the therapeutic effect

Method used

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  • Brucea javanica oil emulsion, preparation method and application
  • Brucea javanica oil emulsion, preparation method and application
  • Brucea javanica oil emulsion, preparation method and application

Examples

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Effect test

Embodiment 1

[0021] The preparation of embodiment 1 Brucea javanica oil

[0022] According to the main component of Brucea javanica extract, oleic acid is an oily substance, it is generally extracted by organic solvent extraction, and the commonly used solvent is mainly petroleum ether. Strictly select raw materials of Brucea javanica, because the peel of Brucea javanica is hard and dense, and its fatty oil is contained in the kernel of Brucea javanica, the peel and seeds of Brucea javanica must be crushed before extraction. Accurately weigh 500g, place in the medicine soaking pot, add 3000mL sherwood oil with the solvent volume ratio of 1:6 (Kg / L, wherein " 1 " is Brucea Bruceae powder weight Kg, " 6 " is solvent volume L), in Carry out sealed soaking at room temperature for 24 hours, during which regular stirring is required to facilitate the full dissolution of the active ingredients, and then vacuum filtration to obtain the filtrate and filter residue, the filtrate is set aside, and th...

Embodiment 2

[0023] The preparation of embodiment 2 Brucea javanica oil emulsion

[0024] Brucea javanica oil is brownish yellow, clear oily liquid, soluble in chloroform, ether, slightly soluble in ethanol, insoluble in water, its main component is oleic acid, clinically made Brucea javanica oil emulsion (for oil-in-water type O / W emulsion), the emulsion particle is about 1 μm, and the finished product is a milky white uniform milky liquid. According to the literature and after screening, the Brucea javanica oil emulsion prescription was obtained: Brucea javanica oil 0.5mL, Tween-800.12mL, glycerin 0.125mL, sterile distilled water added to 5mL. Specific preparation method: Add 0.5mL of javanica javanica oil to 0.12mL of Tween-800.12mL and 0.125mL of glycerol, stir well, then gradually add water for injection to 5mL, stir evenly, filter and divide into 10mL centrifuge tubes, seal, and wash Sterilize by microporous membrane to get 10% Brucea javanica oil (mL / mL: 1mL liquid medicine is dis...

Embodiment 3

[0031] Add Tween-800.12mL, cysteine ​​hydrochloride 0.05g, and glycerol 0.125mL to 0.5mL Brucea javanica oil, stir well, then gradually add water for injection to 5mL, stir well, filter and pack into 10mL centrifuge tubes, seal , to obtain 10% Brucea javanica oil (mL / mL: 1mL liquid medicine is dissolved in 1mL sterile distilled water) oil emulsion finished product through microporous membrane sterilization when ready for use.

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Abstract

The invention relates to a bruceolic oil emulsion, a preparation method and application, belonging to the technical field of traditional Chinese medicine preparations. The novel bruceolic oil emulsion is designed by changing types and amounts of auxiliary materials, the auxiliary materials used in the bruceolic oil emulsion are low in price and small in amount, and the new preparation is relatively good in anti-tumor effect; the bruceolic oil emulsion consists of 0.5ml of bruceolic oil, 0.12ml of Tween-80, 0.125ml of glycerinum and the balance of sterile water, wherein the total amount is 5ml. The bruceolic oil emulsion provided by the invention has an anti-tumor effect superior to that of a common bruceolic oil emulsion injection in the market, the amount of the Tween-80 serving as one auxiliary material is half that of soybean lecithin in a conventional product, the amount of the Tween-80 is very low, and requirements on the amount of the Tween-80 in an injection can be met.

Description

technical field [0001] The invention relates to javanica javanica oil emulsion, a preparation method and application, and belongs to the technical field of traditional Chinese medicine preparations. Background technique [0002] Brucea javanica is the ripe fruit of Brucea javanica (L.) Merr, also known as Brucea javanica, Sophora flavescens, etc. It is bitter in taste, cold in nature, slightly poisonous, and belongs to the large intestine and liver meridian. Brucea javanica has the effects of clearing heat and detoxifying, cutting off malaria, stopping dysentery, and corroding superfluous skin. For the treatment of febrile dysentery or blood in the stool, malaria, corns and other diseases. Modern pharmacological studies have proved that Brucea javanica contains a large amount of bitterwood lactone compounds, which have biological activities such as anti-malarial, anti-amebic dysentery, antifeedant, insecticide, anti-inflammatory and anti-cancer. Brucea javanica oil mainly ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K36/185A61K47/26A61P35/00
CPCA61K9/107A61K36/185A61K47/26
Inventor 刘东玲吴国泰王瑞琼包婧婧刘雪枫马骏
Owner GANSU UNIV OF CHINESE MEDICINE
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