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Spraying type aqueous chitosan wound dressing

A wound dressing and chitosan technology, applied in medical science, bandages, etc., can solve the problems of chemical residues, long film-forming time, health hazards, etc., and achieve good water resistance, accelerated healing, and easy to carry effects

Inactive Publication Date: 2017-03-22
山东康康新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it takes a long time to form a film, and because there is acid residue in the formed chitosan film, it will redissolve when it encounters water, resulting in poor water resistance.
In addition, the residues of chemical substances have potential health hazards to the human body

Method used

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  • Spraying type aqueous chitosan wound dressing
  • Spraying type aqueous chitosan wound dressing
  • Spraying type aqueous chitosan wound dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Take by weighing the chitosan gel of 1g amount, the viscosity-average molecular weight (Mn) of the chitosan that prepares chitosan gel is 100000, and deacetylation degree is 95%, is dispersed in the distilled water of 100mL with homogenizer , to obtain uniformly dispersed chitosan turbid solution; keep the chitosan turbid solution at 5°C, and then pass carbon dioxide gas under a certain pressure state, and observe the color change of the solution, it can be found that the chitosan gel is turbid With the introduction of carbon dioxide, the solution changes from turbidity to clear and transparent state. Therefore, it can be seen that under the condition of low temperature and high pressure, chitosan gel can be dissolved in carbon dioxide.

[0035] Use a polarizing microscope (DYP-990 polarizing microscope, Shanghai Dianying Optical Instrument Co., Ltd.) to observe the dissolution of chitosan before and after the amount of carbon dioxide, and the magnification is 400 times...

Embodiment 2

[0037] Chitosan is made into a hydrogel, and then uniformly dispersed in distilled water, and carbon dioxide gas is continuously introduced under high pressure and low temperature conditions to obtain a chitosan solution, which is then sterilized by irradiation, canned, and sprayed chitosan is obtained. The syrup wound dressing and the chitosan aqueous wound dressing are stored in a high-pressure container bottle, and the spray-on chitosan aqueous wound dressing is composed of chitosan, glycerin, carbon dioxide and distilled water system, and the mass percentages of each component are respectively: Chitosan 4%, glycerin 2%, carbon dioxide 20%, distilled water 74%, wherein, the degree of deacetylation=90% of chitosan is selected, and the viscosity average molecular weight (Mη) is respectively: 10000, 50000, 100000, 170000.

[0038] Take pictures of the appearance of spray-on chitosan aqueous wound dressing prepared by chitosan with different viscosity-average molecular weight, s...

Embodiment 3

[0040] Chitosan is made into a hydrogel, and then uniformly dispersed in distilled water, and carbon dioxide gas is continuously introduced under high pressure and low temperature conditions to obtain a chitosan solution, which is then sterilized by irradiation, canned, and sprayed chitosan is obtained. The syrup wound dressing and the chitosan aqueous wound dressing are stored in a high-pressure container bottle, and the spray-on chitosan aqueous wound dressing is composed of chitosan, glycerin, carbon dioxide and distilled water system, and the mass percentages of each component are respectively: Chitosan 4%, glycerin 2%, carbon dioxide 20%, distilled water 74%, wherein, the viscosity average molecular weight (Mη) is: 50000, the degree of deacetylation (DD) of choosing chitosan is 75%, 90%, 95%, respectively. %.

[0041] Take pictures of the appearance of spray-on chitosan aqueous wound dressing prepared by choosing chitosan with different deacetylation degrees, see image ...

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PUM

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Abstract

The invention discloses a spraying type aqueous chitosan wound dressing, which belongs to the technical field of the medical wound dressing. The spraying type aqueous chitosan wound dressing comprising chitosan, glycerinum, carbon dioxide, and distilled water is stored into a high-pressure-resistant container bottle with a nozzle in a canning mode. Because a carbon-dioxide aqueous solution is used as a solvent for chitosan, the potential hazard on the health of a user by the acid residual in the used chitosan film can be eliminated. Moreover, the prepared chitosan film has the excellent water-resistant performance and high air permeability and flexibility; and when the spraying type aqueous chitosan wound dressing is used, wound healing can be accelerated.

Description

technical field [0001] The invention relates to a spray-coated chitosan aqueous solution wound dressing, which belongs to the technical field of medical wound dressings. Background technique [0002] The skin has the important functions of resisting the invasion of pathogenic bacteria outside the body, excreting human waste, preventing the evaporation of water in the human body, regulating the temperature of the human body, and sensing external stimuli. When the skin is damaged due to trauma, abrasions, burns, and ulcers, it is easy to cause local or even systemic problems, such as excessive loss of water and protein, immune system imbalance, bacterial infection, etc., which can be serious or even life-threatening. Therefore, when the skin is damaged, it is necessary to use wound dressings to accelerate hemostasis, protect the wound surface, prevent bacterial infection, create a suitable wound repair environment, and accelerate wound healing. Traditional wound dressings are...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/008C08L5/08
Inventor 张传杰朱平颜超
Owner 山东康康新材料科技有限公司