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Method for constructing allergic rhinitis model in non-human mammal by using pollen of Cryptomeria fortunei

A non-human mammal, allergic rhinitis technology, applied in the field of constructing non-human mammal allergic rhinitis model using cedar pollen, can solve the problems of lower respiratory tract sensitization, easy to cause asthma, etc. The effect of high rate and high model survival rate

Inactive Publication Date: 2017-04-12
贺淼
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned process is quite different from the natural process of allergic rhinitis, and atomized inhalation of allergens can easily cause sensitization of the lower respiratory tract, which can easily lead to asthma after stimulation

Method used

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  • Method for constructing allergic rhinitis model in non-human mammal by using pollen of Cryptomeria fortunei
  • Method for constructing allergic rhinitis model in non-human mammal by using pollen of Cryptomeria fortunei
  • Method for constructing allergic rhinitis model in non-human mammal by using pollen of Cryptomeria fortunei

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Embodiment Construction

[0027] In order to illustrate the embodiments of the present invention or the technical solutions in the prior art more clearly, the drawings required in the description of the embodiments or the prior art will be briefly introduced below.

[0028] The invention provides a method for constructing a non-human mammalian allergic rhinitis model, using a Cryj1 solution for local sensitization and stimulation through the nose.

[0029] The method for constructing non-human mammal allergic rhinitis model provided by the embodiments of the present invention figure 1 ):

[0030] Step 1. Instill a solution containing Cryj1 into the nasal cavity of a non-human mammal every two weeks from the first day, for a total of four times;

[0031] Step 2. After the fourth exposure, the solution containing Cryj1 was dripped into the nasal cavity of non-human mammals every two days for a total of four times.

[0032] The specific implementation steps of this method are: weigh the BALB / c mice requ...

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Abstract

The invention relates to a method for constructing an allergic rhinitis model in a non-human mammal by using the pollen of Cryptomeria fortunei, belonging to the field of construction of animal models of allergic rhinitis. The pollen of Cryptomeria fortunei (Cryj1) is used as an allergen, and a solution containing Cryj1 is dripped into the nostrils of a non-human mammal so as to construct a model for allergic pollen, wherein the non-human mammal is a mouse. The allergic rhinitis model in the non-human mammal is successfully constructed in the invention, and the model realizes abnormal proliferation of epidermal goblet cells in the nasal cavities and increased secretion of mucus.

Description

technical field [0001] The invention relates to the field of constructing allergic rhinitis animal models, in particular to a method for constructing non-human mammalian allergic rhinitis models using cedar pollen. Background technique [0002] Allergic rhinitis (allergic rhinitis, AR) is an allergic disease that occurs in the nasal mucosa due to the increased sensitivity of the body to certain allergens. It is a common and frequently-occurring disease among respiratory diseases. According to European and American statistics, the incidence of allergic rhinitis has increased by about 30% in the past 10 years. With the development of industrialization in my country, the incidence of allergic rhinitis is also increasing, especially in spring and summer. high. [0003] Cedar is a widely used afforestation tree species in China and Japan, and it is also planted in Europe, North America, and Nepal and India in the east of the Himalayas. In Japan, the coverage rate of cedar can re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/36A61K36/14A61K36/00A61K49/00
CPCA61K36/14A61K36/00A61K39/36A61K49/0008
Inventor 贺淼任亚浩刘宁
Owner 贺淼
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