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Preparation method of polylactic acid and inorganic particle complex tissue engineering scaffold

A tissue engineering scaffold and inorganic particle technology, applied in the field of biomedical materials, can solve the problems of difficult to clean, inflammatory reaction of surrounding tissue, affecting the formation and repair effect of new tissue, etc.

Inactive Publication Date: 2017-05-10
王淑芳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The solvents and cross-linking agents used in the prior art are difficult to remove, resulting in cytotoxicity when tissue engineering scaffold materials are used, causing inflammatory reactions in surrounding tissues, destroying the biological activity of cells and tissues, and affecting the formation of new tissues and repair effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A preparation method of polylactic acid and inorganic particle composite tissue engineering scaffold is realized through the following process:

[0026] (1) Compound polylactic acid and inorganic particles (granular), polyvinyl alcohol (powder), and sodium bicarbonate (powder) according to the volume ratio of 1:1:1 to prepare a mixed solution;

[0027] (2) spinning the raw material mixture in step (1) to obtain composite nanofibers of polylactic acid and inorganic particles;

[0028] (3) Put the polylactic acid and inorganic particle composite nanofibers of step (2) into the tissue engineering scaffold mold, then put the tissue engineering scaffold mold with the nanofibers into the supercritical CO with a pressure of 20MPa 2 Medium treatment, control the treatment temperature at 55°C, treat for 1 hour, and then depressurize and discharge CO 2 , the control time is 1 minute, the temperature during decompression is controlled at 70 ℃, and the intermediate product is obta...

Embodiment 2

[0030] The polylactic acid and inorganic particle composite (granular), polyvinyl alcohol (powder), and sodium bicarbonate (powder) were prepared according to the volume ratio of 3:2:3, and the parameters were adjusted in the same steps as in Example 1. of which supercritical CO 2 The middle treatment temperature is controlled at 55°C, treated for 1 hour, and then decompressed to discharge CO 2 , the control time is 1 minute, the temperature during decompression is controlled at 70°C, and the internally interconnected porous material polylactic acid and inorganic particle composite tissue engineering scaffold is obtained. The porosity of the obtained porous material is 73.8%. The size is 20 microns-250 microns, and the size of the internal interconnecting channels is 20 microns-200 microns.

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Abstract

The invention relates to a preparation method of a polylactic acid and inorganic particle complex tissue engineering scaffold. The preparation method comprises the following steps: preparing a mixed solution from 25-40% of a polylactic acid and inorganic particle complex, 30-45% of polyvinyl alcohol and 25-40% of sodium hydrogen carbonate, and then spinning to obtain polylactic acid and inorganic particle complex nano fibers; treating the nano fibers in supercritical CO2 to obtain an intermediate product by controlling treatment pressure and treatment temperature; and leaching the obtained intermediate product in a circulating water bath, and then performing vacuum drying to obtain a tissue engineering scaffold of a porous material of which the porosity reaches 68-74.0%, the cell size is 20-200 microns, and the size of an internal interconnected passage is about 20-200 microns. According to the preparation method provided by the invention, crosslinking and fusion can be completed between fibers at a relatively low temperature without adopting a solvent, a crosslinking agent and the like, and cytotoxicity cannot be generated.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a preparation method of a composite tissue engineering scaffold of polylactic acid and inorganic particles. Background technique [0002] Tissue engineering scaffold material is a material that can be combined with tissue living cells and can be implanted in organisms. It can provide cells with a place to obtain nutrients, gas exchange, excrete waste, and grow and develop. The material basis of organs. [0003] For tissue engineering scaffolds, tissue engineering scaffold materials are the key to the regeneration of tissue defects. The porosity and pore size of tissue engineering scaffold materials are important factors affecting the performance of tissue engineering scaffold materials. In addition to requiring tissue engineering scaffold materials to have a high porosity, there are also strict requirements on the size of the pores. If the pores are too...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/56
CPCA61L27/56A61L27/446A61L2400/12
Inventor 王淑芳
Owner 王淑芳
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