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Affinity peptides associated with Coxsackievirus adenovirus receptor

A technology of coxsackie virus and adenovirus, which is applied to preparations, peptides, and pharmaceutical formulations for in vivo experiments, can solve the problems of cell proliferation activity and tumor formation ability decline, and achieve convenient acquisition channels and low synthesis costs. Effect

Active Publication Date: 2020-07-31
NANJING NUOYUAN MEDICAL DEVICES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

CAR transfection of prostate and glial tumor cell lines lacking CAR expression results in decreased cell proliferative activity and tumor formation

Method used

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  • Affinity peptides associated with Coxsackievirus adenovirus receptor
  • Affinity peptides associated with Coxsackievirus adenovirus receptor
  • Affinity peptides associated with Coxsackievirus adenovirus receptor

Examples

Experimental program
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Effect test

Embodiment 1

[0046] The synthetic process of polypeptide YQC-1 of the present invention

[0047] 1: Coupling

[0048] First, swell 0.33 / 2mmol 6.06g of Fmoc-Arg-Rink amide MBHA resin (fluorenyl methaneoxycarbonyl-arginine-rink amino resin) in dimethylformamide, 10ml / g resin, and then use 20% hexahydro Pyridine / dimethylformamide solution removes the Fmoc protecting group (hereinafter referred to as decapping), washes the resin after decapping with dimethylformamide, adds raw material Fmoc-Lys(Boc)-OH 2.3g, and is used for condensing agent HBTU 1.44g, reaction time 30 minutes, kaiser method detection, if the test result is negative, indicating that the coupling reaction is complete, then proceed to uncapping for 30 minutes, if the test result is still positive, it indicates that the coupling reaction is not complete or The reaction is not complete, it is necessary to prolong the coupling time or re-feed the coupling until the coupling reaction is completed. Repeat the above operations, sequ...

Embodiment 2

[0057] The synthetic process of polypeptide YQC-2 of the present invention

[0058] 1: Coupling

[0059]First, swell 0.33 / 2mmol 6.06g of Fmoc-Lys-Rink amide MBHA resin (Fmoc-Lysine-rink amino resin) in dimethylformamide, 10ml / g resin, and then use 20% hexahydro Pyridine / dimethylformamide solution removes the Fmoc protecting group (hereinafter referred to as decapping), washes the resin after decapping with dimethylformamide, and adds 2.3 g of raw material Fmoc-Cys(Trt)-OH, for condensing agent HBTU 1.44g, reaction time 30 minutes, kaiser method detection, if the test result is negative, indicating that the coupling reaction is complete, then proceed to uncapping for 30 minutes, if the test result is still positive, it indicates that the coupling reaction is not complete or The reaction is not complete, it is necessary to prolong the coupling time or re-feed the coupling until the coupling reaction is completed. Repeat the above operation, sequential coupling; Fmoc-Asp(OtBU)-...

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Abstract

The invention discloses a series of affinity polypeptides YQC-1 and YQC-2 related to a coxsackie adenovirus receptor. The polypeptides possibly realize near-infrared imaging of specific malignant tumors due to the property of specific binding of the coxsackie adenovirus receptor, can be used for preparation of drugs for cell adhesion inhibition, diagnosis or tracing of tumors and targeted chemotherapy and used for pharmaceutical necessities or attachments, so that the aim of nondestructively monitoring early malignant tumors in situ in real time is achieved. The invention relates to the field of drugs related to tumor diagnosis, and in particular to multiple polypeptides, affinity tests of the polypeptides, pharmaceutical compositions taking the polypeptides as active ingredients, and application of the polypeptides in preparation of diagnostic drugs.

Description

technical field [0001] The invention belongs to the technical field of bioengineering and pharmacy, the field of protein polypeptide medicine and biomedical engineering, and specifically relates to a polypeptide with high affinity for Coxsackie virus adenovirus receptor and its application, for example, in cancer diagnosis and treatment. Background technique [0002] At present, cancer has become the biggest culprit that endangers the health of our residents and seriously threatens human health. Clinically, the methods used to treat tumors include surgery, chemical drug therapy, and radiotherapy. Among them, chemotherapy is currently the most widely used method for tumor treatment. In patients with advanced tumors who have lost the opportunity for surgery, chemotherapy is the main treatment method; after surgery for patients with high-risk factors, postoperative adjuvant chemotherapy has also been used. It has been proved that it can reduce the recurrence rate of postoperat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K7/08A61K49/00
CPCA61K49/0032A61K49/0056C07K7/08
Inventor 顾月清赵梦路韩智豪
Owner NANJING NUOYUAN MEDICAL DEVICES CO LTD
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