Application of nano-selenium as cik cell sensitizer

A technology of nano-selenium and sensitizer, which is applied in the field of medicine, can solve problems such as easy tolerance, and achieve the effect of low toxicity and inhibition of proliferation
CN106692181BActive Publication Date: 2020-06-09JINAN UNIVERSITY
2 Cites 1 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JINAN UNIVERSITY
Publication Date
2020-06-09

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses an application of nano-selenium serving as a CIK (cytokine-induced killer) cell sensitizer. The application of the nano-selenium serving as the CIK cell sensitizer refers to applying the nano-selenium as the CIK cell sensitizer to assist CIK cells. The nano-selenium provided by the invention is at least one of pure nano-selenium, polyethylene glycol modified nano-selenium, polyvinylpyrrolidone modified nano-selenium, chitosan modified nano-selenium, polysaccharide modified nano-selenium, folic acid modified tumor-targeting nano-selenium and transferrin modified tumor-targeting nano-selenium; and the CIK cells are obtained by performing mononuclear cell separation on human peripheral blood, bone marrow or cord blood, and performing induced culture by using a CD-3 antibody and IFN-gamma and IL-2 in vitro. The nano-selenium sensitizer disclosed by the invention has low-price and easily-available raw materials, synthesis and purification steps are strong in operability, and the synthesis scale can be appropriately enlarged by virtue of process optimization, thereby achieving commercialization and application of the medicine.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of medicine, and particularly relates to the application of nano-selenium as a CIK cell sensitizer. Background technique

[0002] In recent years, the good news of tumor immunotherapy has continued. At present, it has demonstrated strong anti-tumor activity in the treatment of some tumor types such as melanoma, gastric cancer and non-small cell lung cancer. FDA (Food and Drug Administration, FDA) approved clinical application. Due to its excellent efficacy and innovation, tumor immunotherapy was named the most important scientific breakthrough of the year by Science in 2013 [Science, 2013, 342:1666]. Tumor immunotherapy is expected to become an innovation in the field of tumor treatment following surgery, chemotherapy, radiotherapy, and targeted therapy [Yao Yang, et al. Nanoscale Research Letters, 2016, 11:285]. CIK cells refer to autologous cytokine-induced killer cells, which are powerful anti-tumor or ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More