Device for detecting human body microvessel ultrastructure through circular polarization side flow dark field imaging technique

A dark-field imaging and ultra-microstructure technology, which is applied in the field of medical devices, can solve the problems of non-reflection of light, low light utilization rate, and unclear imaging, and achieve good imaging performance, good transmission ability, and good imaging clarity.

Active Publication Date: 2017-05-31
QINGDAO UNIV
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  • Description
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AI Technical Summary

Problems solved by technology

[0006] However, the traditional lateral flow dark-field imaging technology uses a ring-shaped LED light source to surround the lens of the imaging microscope objective lens. Since the light source is not polarized, most of the light is scattered and cannot be reflected into the imaging microscope objective lens. That is to say, the utilization rate of light is extremely low, and the imaging is very unclear.

Method used

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  • Device for detecting human body microvessel ultrastructure through circular polarization side flow dark field imaging technique
  • Device for detecting human body microvessel ultrastructure through circular polarization side flow dark field imaging technique
  • Device for detecting human body microvessel ultrastructure through circular polarization side flow dark field imaging technique

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Embodiment 1

[0040] Such as Figure 2-3 A device for detecting the ultrastructure of human microvessels using circularly polarized lateral flow dark-field imaging technology shown, at least includes: a light source module capable of emitting linearly polarized light; a dimming unit capable of modulating linearly polarized light into circularly polarized light; A lens unit that can magnify and image the object to be observed; an imaging unit that can image the light reflected by the object to be measured; and an imaging module that can process the reflected light with information about the object to be measured after being reflected by the lens unit to form an image; Wherein, the light source module is located on the periphery of the lens of the lens unit, and the light source module is provided with a dimming unit in front of the light irradiation direction.

[0041] Further, the imaging module is a digital camera with a CCD sensor or a CMOS sensor.

[0042] Further, the light source modu...

Embodiment 2

[0064] Different from Example 1, as Figure 7-8 As shown, the central axis of the through hole intersects the axis of the lens unit center, and the intersection point is located in the direction of incident light. Of course, the cover can be set in a cylindrical shape, or a truncated cone shape, and it is only necessary to adjust the installation angle according to the exposure of the incident light. This setting is to improve the utilization rate of incident light.

[0065] When a laser or LED light source is irradiated on a plane, the light intensity has a Gaussian distribution in the irradiated range, such as Figure 10 shown. When each laser of the ring light source is irradiated vertically, the light intensity actually irradiated to the observation range of the objective lens is about 10% of the light intensity at the center of the illumination, resulting in a waste of light utilization.

[0066] Using the oblique lighting method, the center of the light is adjusted to...

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Abstract

The invention relates to a device for detecting a human body microvessel ultrastructure through a circular polarization side flow dark field imaging technique. The device at least comprises a light source module capable of emitting linearly polarized light, a light modulating unit capable of modulating the linearly polarized light into circular polarized light, a lens unit capable of imaging an observed object in an amplifying mode, an imaging unit capable of imaging light reflected by the observed object and an image displaying module capable of processing the reflected light which is obtained through reflection of the lens unit and carries information of the observed object to form an image, wherein the light source module is located at the periphery of a lens the lens unit, and the light modulating unit is arranged in front of the light irradiation direction of the light source module. Accordingly, the device has the imaging performance which is better than that of a traditional imaging device; by arranging annular light sources at the lens part of a microscope objective to replace LED light sources which are originally arranged behind the microscope objective in the device, the distance between the light sources and the observed object is decreased, the light utilization efficiency is greatly improved, and then the energy value of a semiconductor laser can be decreased.

Description

technical field [0001] The invention relates to a medical device for medical diagnosis using optical imaging technology, in particular to a device for detecting ultrastructure of human microvessels by using circular polarization lateral flow dark field imaging technology. Background technique [0002] Microcirculation refers to the place where blood and tissue cells exchange substances between arterioles and venules. The integrity of the function, shape and metabolism of the microcirculation is an indispensable condition for maintaining the normal function of human organs. Through the study of microcirculation, it is convenient to further understand the special functions of various organs of the human body, and to recognize the pathogenesis of diseases, which is beneficial to disease prevention, diagnosis and treatment. A variety of disease states, including diabetes, hypertension and coronary heart disease, will cause pathological changes in microcirculation, including cha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00
CPCA61B5/0059A61B5/0077
Inventor 董蒨于綦悦魏宾夏楠
Owner QINGDAO UNIV
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