Ibuprofen oral suspension and preparation method thereof

A technology of suspension and raw materials, applied in the field of medicine, can solve the problems of ibuprofen unable to maintain body temperature, drug aggregation and sedimentation or floating, easy aggregation of drug particles, etc. Effects of immunity

Inactive Publication Date: 2017-05-31
TIANDA PHARMA ZHUHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, ibuprofen is a kind of medicine with low melting point and light weight. After being placed for a long time, its drug particles are easy to aggregate, so that the phenomenon of drug aggregation, sedimentation or floating occurs more or less, and it is difficult to maintain good stability, resulting in The actual amount of medicine t

Method used

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  • Ibuprofen oral suspension and preparation method thereof
  • Ibuprofen oral suspension and preparation method thereof
  • Ibuprofen oral suspension and preparation method thereof

Examples

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preparation example Construction

[0025] In addition, the present invention also provides the preparation method of above-mentioned ibuprofen suspension, comprises the steps:

[0026] S201: add sucrose, xanthan gum and pregelatinized starch into water and disperse evenly to obtain a slurry; the ratio of the total mass of sucrose, xanthan gum and pregelatinized starch to the mass of water is 1:(0.8~1.1);

[0027] S202: Under vacuum conditions, add glycerin, Tween 80 and citric acid to water, disperse evenly, add crushed ibuprofen, add the obtained mixed solution to the slurry, then add sodium benzoate, essence, pigment red and the second Other raw materials in the two components; the ratio of the total mass of glycerin, Tween 80 and citric acid to the mass of water is 1: (1.0 ~ 1.2); the vacuum degree under vacuum conditions is -0.092MPa ~ -0.08MPa, pulverized The particle size of the final ibuprofen does not exceed 75 μm.

[0028] S203: Crush all the raw materials in the third component and mix them evenly wi...

Embodiment 1

[0033] The present embodiment provides a kind of ibuprofen suspension, in every 100mL ibuprofen suspension, comprise the raw material of following weight ratio: ibuprofen 1.0g, glycerol 9g, sucrose 27g, pregelatinized starch 1.2g, Xanthan gum 0.15g, Tween 80 0.04g, citric acid 0.15g, sodium benzoate 0.15g, essence 0.1g and pigment red 0.003g.

[0034] According to above-mentioned raw material, adopt the preparation method of ibuprofen suspension provided by the invention, prepare 100mL ibuprofen suspension:

[0035] S101: adding sucrose, xanthan gum and pregelatinized starch into water and dispersing evenly, the ratio of the total mass of sucrose, xanthan gum and pregelatinized starch to the mass of water is 1:1.1 to obtain a slurry;

[0036] S102: Add glycerin, Tween 80 and citric acid to water under the condition of vacuum degree of -0.08MPa, the ratio of the total mass of glycerin, Tween 80 and citric acid to the mass of water is 1:1.2, and after the dispersion is uniform ...

Embodiment 2

[0038] The present embodiment provides a kind of ibuprofen suspension, in every 100mL ibuprofen suspension, comprise the raw material of following weight ratio: ibuprofen 5.0g, glycerol 11g, sucrose 32g, pregelatinized starch 1.4g, Xanthan gum 0.25g, Tween 80 0.06g, citric acid 0.25g, sodium benzoate 0.2g, essence 0.3g and pigment red 0.006g.

[0039] According to above-mentioned raw material, adopt the preparation method of ibuprofen suspension provided by the invention, prepare 100mL ibuprofen suspension:

[0040] S101: adding sucrose, xanthan gum and pregelatinized starch into water and dispersing evenly, the ratio of the total mass of sucrose, xanthan gum and pregelatinized starch to the mass of water is 1:0.8 to obtain a slurry;

[0041] S102: Add glycerin, Tween 80, and citric acid to water under the condition of a vacuum of -0.092MPa, the ratio of the total mass of glycerin, Tween 80, and citric acid to the mass of water is 1:1.0, and after uniform dispersion Add crush...

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Abstract

The invention relates to an ibuprofen oral suspension and a preparation method thereof. The ibuprofen oral suspension is characterized in that a raw material comprises a first component and a second component; based on every 100 mL ibuprofen oral suspension, the first compound comprises 1.0-5.0 g of ibuprofen; and the second compound comprises 8-12 g of glycerinum, 25-35 g of saccharose, 1.1-1.5 g of pregelatinized starch, 0.15-0.25 g of xanthan gum, 0.03-0.07 g of twain 80, 0.15-0.25 g of citric acid, 0.15-0.25 g of sodium benzoate, 0.1-0.3 g of essence, and 0.003-0.006 g of haematochrome. According to the ibuprofen oral suspension, the stability of the ibuprofen oral suspension after the ibuprofen oral suspension is stored for a long time can be improved, and floating or settling can be avoided; the effects of relieving pain and relieving fever can be improved; and the damage and stimulus to gastrointestinal mucosa is reduced after the ibuprofen oral suspension is orally taken.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an ibuprofen oral suspension and a preparation method thereof. Background technique [0002] Ibuprofen (Ibuprofen), also known as ibuprofen, is a non-steroidal anti-inflammatory analgesic. Its anti-inflammatory, analgesic and antipyretic effects are good, and its adverse reactions are relatively small. It has been widely used in the world at present. It has become one of the best-selling over-the-counter drugs in the world, and is listed as the three pillar products of antipyretic and analgesic drugs together with aspirin and paracetamol. Ibuprofen has both antirheumatic and antipyretic and analgesic effects, and has low toxicity. It is superior to aspirin and paracetamol in terms of curative effect and side effects. Ibuprofen is a safe and effective antipyretic drug. When the body temperature is higher than 39.2°C, ibuprofen is more effective than paracetamol at the same dose,...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/192A61K36/9066A61K36/9068A61K47/36A61K47/26A61K47/12A61K47/44A61K47/38A61K47/32A61P29/00A61P11/14A61K35/64
CPCA61K36/185A61K9/0053A61K9/10A61K31/192A61K35/63A61K36/16A61K36/23A61K36/233A61K36/238A61K36/30A61K36/483A61K36/488A61K36/54A61K36/65A61K36/704A61K36/71A61K36/734A61K36/736A61K36/815A61K36/835A61K36/89A61K36/899A61K36/9066A61K36/9068A61K47/12A61K47/26A61K47/32A61K47/36A61K47/38A61K47/44A61K2236/331A61K2300/00
Inventor 陆炜洪覃钧全贺艳兰
Owner TIANDA PHARMA ZHUHAI
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