Ibuprofen oral suspension and preparation method thereof

Abstract

The invention relates to an ibuprofen oral suspension and a preparation method thereof. The ibuprofen oral suspension is characterized in that a raw material comprises a first component and a second component; based on every 100 mL ibuprofen oral suspension, the first compound comprises 1.0-5.0 g of ibuprofen; and the second compound comprises 8-12 g of glycerinum, 25-35 g of saccharose, 1.1-1.5 g of pregelatinized starch, 0.15-0.25 g of xanthan gum, 0.03-0.07 g of twain 80, 0.15-0.25 g of citric acid, 0.15-0.25 g of sodium benzoate, 0.1-0.3 g of essence, and 0.003-0.006 g of haematochrome. According to the ibuprofen oral suspension, the stability of the ibuprofen oral suspension after the ibuprofen oral suspension is stored for a long time can be improved, and floating or settling can be avoided; the effects of relieving pain and relieving fever can be improved; and the damage and stimulus to gastrointestinal mucosa is reduced after the ibuprofen oral suspension is orally taken.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an ibuprofen oral suspension and a preparation method thereof. Background technique [0002] Ibuprofen (Ibuprofen), also known as ibuprofen, is a non-steroidal anti-inflammatory analgesic. Its anti-inflammatory, analgesic and antipyretic effects are good, and its adverse reactions are relatively small. It has been widely used in the world at present. It has become one of the best-selling over-the-counter drugs in the world, and is listed as the three pillar products of antipyretic and analgesic drugs together with aspirin and paracetamol. Ibuprofen has both antirheumatic and antipyretic and analgesic effects, and has low toxicity. It is superior to aspirin and paracetamol in terms of curative effect and side effects. Ibuprofen is a safe and effective antipyretic drug. When the body temperature is higher than 39.2°C, ibuprofen is more effective than paracetamol at the same dose,...

AI Technical Summary

Problems solved by technology

However, ibuprofen is a kind of medicine with low melting point and light weight. After being placed for a long time, its drug particles are easy to aggregate, so that the phenomenon of drug aggregation, sedimentation or floating occurs more or less, and it is difficult to maintain good stability, resulting in The actual amount of medicine taken is more or less than expected, resulting in drug poisoning or ineffectiveness; moreover, ibuprofen cannot effectively maintain the body temperature all the time, and the body temperature rises easily after the fever is reduced, and the body temperature fluctuates greatly. Fen has a certain stimulating effect on the gastrointestinal tract

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