Gynecological foaming agent and preparation method thereof

A foaming agent and gynecological technology, applied in the field of foaming agents, can solve the problems of short action time of lotion, residual color and odor, damage to the epidermis, etc., and achieve the effect of low investment in production equipment, safe, hygienic and convenient use, and wound repair.

Inactive Publication Date: 2017-05-31
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some of the existing disposable lotions on the market feel uncomfortable after use and damage the epidermis. Afterwards, there are often color and odor residues, and most of the lotions have a short action time

Method used

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  • Gynecological foaming agent and preparation method thereof
  • Gynecological foaming agent and preparation method thereof
  • Gynecological foaming agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A gynecological foam preparation prepared from the following raw materials by weight percentage: 1.0% chitosan, 1% acetic acid, 0.5% glycerin, 0.01% fatty alcohol polyoxyethylene ether, 1.5% alkanolamide, and the rest is purified water.

[0033] Described chitosan is through purification process, comprises the steps:

[0034] 1) Dissolve chitosan in water with a balance, and stir until completely dissolved to obtain the first solution;

[0035] 2) coarsely filter the first solution with a stainless steel screen to obtain the second solution;

[0036] 3) Filtrating the second solution for a second time to obtain a third solution; the second filtration uses a microporous membrane for high-pressure suction filtration.

[0037] 4) adding ethanol while stirring makes chitosan precipitate, and the volume ratio of ethanol and the third solution is 3:1; Then filter after centrifuging at a rotating speed of 6000 rpm for 30 minutes to obtain purified chitosan;

[0038] 5) Dry ...

Embodiment 2

[0055] A gynecological foam preparation is prepared from the following raw materials by weight percentage: 1.5% chitosan oligosaccharide, 0% acetic acid, 5% glycerin, 1.2% alkyl glycoside, and the rest is purified water.

[0056] Described chitosan oligosaccharide is through purification process, comprises the steps:

[0057] 1) Weigh the chitosan oligosaccharide with a balance and dissolve it in water, and stir until completely dissolved to obtain the first solution;

[0058] 2) coarsely filter the first solution with a stainless steel screen to obtain the second solution;

[0059] 3) Filtrating the second solution for a second time to obtain a third solution; the second filtration uses a microporous membrane for high-pressure suction filtration.

[0060] 4) Adding ethanol while stirring makes the chitosan oligosaccharide precipitate, and the volume ratio of ethanol to the third solution is 3:1; then centrifuges at a speed of 6000 rpm for 30 minutes and then filters to obtain ...

Embodiment 3

[0077] A gynecological foam preparation, prepared from the following raw materials by weight percentage: chitosan quaternary ammonium salt 0.5%, acetic acid 0%, glycerin 2%, alkyl glycoside 0.5%, Tween 0.01%, and the rest is purified water.

[0078] Chitosan quaternary ammonium salt is purified, including the following steps:

[0079] 1) Dissolve chitosan quaternary ammonium salt in water with a balance, and stir until completely dissolved to obtain the first solution;

[0080] 2) coarsely filter the first solution with a stainless steel screen to obtain the second solution;

[0081] 3) Filtrating the second solution for a second time to obtain a third solution; the second filtration uses a microporous membrane for high-pressure suction filtration.

[0082] 4) adding ethanol while stirring to precipitate chitosan quaternary ammonium salt, the volume ratio of ethanol to the third solution is 3:1; then centrifuge at 6000 rpm for 30 minutes and filter to obtain purified chitosa...

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Abstract

The invention discloses a gynecological foaming agent and a preparation method thereof. The gynecological foaming agent is prepared from the following raw materials in percentage by weight: 0.5-1.5% of chitosan or a chitosan derivative, 0-1% of acetic acid, 0.5-5% of glycerin, 0.01-1.5% of a bubble-rich surfactant and the balance of water. As a foaming agent, medicines can be uniformly distributed inside vaginal canals and skin surfaces, the distribution area can be large, dense foams can be generated, the medicine action time can be relatively long, the medicines can effectively infiltrate into vagina mucosa wrinkles, and a treatment effect can be brought into play relatively, sufficiently and rapidly. The gynecological foaming agent is dense in foam, good in sterilization effect, safe, sanitary and convenient to use, and applicable to treatment on various types of kysthitis, nursing on uterine neck wound, remediation of wound surfaces and promotion of anabrosis heal.

Description

technical field [0001] The invention relates to a foaming agent, in particular to a gynecological foaming agent and a preparation method thereof. Background technique [0002] Chitosan (chitosan) is obtained by deacetylation of chitin (chitin), which exists widely in nature, and its chemical name is polyglucosamine (1-4)-2-amino-B-D glucose. Chitin or chitosan and its derivatives are more and more widely used in medicine, and can be used as drug carriers, such as controlled release agents and sustained release agents, making pharmaceutical preparations "three highs" (high-efficiency, quick-acting, long-term Effect) and "three small" (low toxicity, small side effects, small dose) development, such as the current microcapsule material is a research hotspot. A series of derivatives with excellent properties suitable for different needs can be obtained through structural modification of chitosan. Chitosan and its derivatives have good antibacterial activity and can inhibit the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K47/26A61K47/10A61K47/18A61K31/722A61P15/02A61P17/02A61P31/04A61P31/10
CPCA61K9/122A61K9/0034A61K31/722A61K47/10A61K47/18A61K47/26
Inventor 谢佩思车七石钟经德
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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