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Polypeptide nano-material containing double-pyrene groups as well as preparation method and application of polypeptide nano-material

A nanomaterial and pyrene group technology is applied in the field of polypeptide nanomaterials containing bipyrene groups and their preparation, which can solve the problems of little effect and achieve the effect of inhibiting invasion and metastasis.

Active Publication Date: 2017-05-31
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, once most tumor diseases are found to have entered the advanced stage, the invasion and metastasis of tumor cells have already occurred, so the practice of inhibiting MMP activity to control tumor development has little effect

Method used

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  • Polypeptide nano-material containing double-pyrene groups as well as preparation method and application of polypeptide nano-material
  • Polypeptide nano-material containing double-pyrene groups as well as preparation method and application of polypeptide nano-material
  • Polypeptide nano-material containing double-pyrene groups as well as preparation method and application of polypeptide nano-material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] In this example, the structure of the polypeptide nanomaterial containing bispyrene group is as follows:

[0067]

[0068] That is, in the structure shown in formula I, R 1 The donor is KLVFFK, R 2 The donor is YIGSR, R 3 The donor is GGDGR.

[0069] The polypeptide nanomaterial containing bispyrene group is synthesized by the solid-phase synthesis (SPPS) method of the polypeptide, and the experimental steps of the polypeptide solid-phase synthesis method are as follows:

[0070] Using Wang's resin as a carrier, after swelling in anhydrous DMF for 6 hours, according to the peptide synthesis sequence, at room temperature, add amino acids (10 times the equivalent, the amino acid is to carry out specific active groups to some active groups) protected amino acid) and HBTU (benzotriazole-N,N,N',N'-tetramethyluronium hexafluorophosphate, 10 equivalents), through a coupling agent (nitromethylmorpholine: DMF= 5:95, volume ratio) for coupling for 45min, and the amino acid...

Embodiment 2

[0074] In this example, the structure of the polypeptide nanomaterial containing bispyrene group is as follows:

[0075]

[0076] That is, in the structure shown in formula I, R 1 The donor is KLPFFDK, R 2 The donor is YIGSR, R 3 The donor is GGDGR.

[0077] The polypeptide nanomaterials containing bispyrene groups are synthesized by the solid phase synthesis (SPPS) method of polypeptides, Wang's resin is selected as the carrier, and corresponding amino acids are selected for solid phase synthesis according to the sequence of polypeptides in the structure, bispyrene The compounds were also reacted according to the amino acid coupling method, and the synthesis process was similar to Example 1, and the polypeptide nanomaterial containing bispyrene groups of this example was synthesized.

Embodiment 3

[0079] In this example, the structure of the polypeptide nanomaterial containing bispyrene group is as follows:

[0080]

[0081] That is, in the structure shown in formula I, R 1 The donor is KLVFFK, R 2 The donor is DGEA, R 3 The donor was KQAGDV.

[0082] The polypeptide nanomaterials containing bispyrene groups are synthesized by the solid phase synthesis (SPPS) method of polypeptides, Wang's resin is selected as the carrier, and corresponding amino acids are selected for solid phase synthesis according to the sequence of polypeptides in the structure, bispyrene The compounds were also reacted according to the amino acid coupling method, and the synthesis process was similar to Example 1, and the polypeptide nanomaterial containing bispyrene groups of this example was synthesized.

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Abstract

The invention provides a polypeptide nano-material containing double-pyrene groups as well as a preparation method and an application of polypeptide nano-material. The polypeptide nano-material containing the double-pyrene groups has a structure represented as a formula I; the polypeptide nano-material containing the double-pyrene groups can be deformed for self-assembly and can be self-assembled to form a nanofiber network structure in a tumor area and construct an artificial cell extracellular matrix in situ, and the artificial cell extracellular matrix selectively adheres to the tumor area to form a migration barrier, so that tumor invasion and metastasis can be effectively inhibited, and the polypeptide nano-material has board medical application prospect.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, and relates to a polypeptide nanomaterial containing a bispyrene group and its preparation method and application. Background technique [0002] Tumor metastasis is an important biological feature of malignant tumors, and it is also the main cause of treatment failure and death in most clinical tumor patients. Malignant tumors are an increasing threat to patients' health, and preventing tumor metastasis is the key to improving cancer treatment. According to the statistical analysis report of the National Health and Family Planning Commission on the national death registration report information system in January 2015, among all 31 provinces, malignant tumors ranked first in 6 provinces (accounting for 46.2%). According to the results of the analysis of the rate, the top two causes of death affecting the health of Chinese residents are malignant tumors and cerebrovascular diseases. At pres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/06C07K7/08B82Y40/00C07K1/04A61K47/42A61P35/04
CPCA61K47/42B82Y40/00C07K7/06C07K7/08
Inventor 王浩王磊郝红勋胡晓雪
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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