A preparation method of self-healing polyurethane hydrogel based on double selenium dynamic covalent bond

A dynamic covalent bond and hydrogel technology, applied in prosthetics, medical science, etc., to achieve good biocompatibility, good molecular structure designability, and broad application prospects

Active Publication Date: 2019-04-19
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no related reports on visible light self-healing hydrogels based on diselenium dynamic covalent bonds

Method used

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  • A preparation method of self-healing polyurethane hydrogel based on double selenium dynamic covalent bond

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Distill polyethylene glycol under reduced pressure for 8 hours at 90°C and a vacuum of 0.09 MPa to remove water; add 20 g of polyethylene glycol with a number-average molecular weight of 4000, 2.23 g of isofor to a three-necked flask in sequence Ketone diisocyanate, 15ml of N,N-dimethylformamide, 1 drop of dibutyltin dilaurate, heated to 85°C under magnetic stirring, and reacted for 3 hours; added 0.62g of diselenide, and continued to react for 3 hours Hours; turn off the heating, cool naturally to 20°C, add 0.57g diethanolamine, and react for 2 hours; add 1.12g isophorone diisocyanate to the product, mix evenly, and move it into a mold, and put it in an oven at 40°C for 48 hours Cross-linking and curing: demould the shaped block gel, soak it in deionized water, change the water every 6 hours, and obtain a self-healing polyurethane hydrogel based on the dynamic covalent bond of double selenium after 48 hours.

Embodiment 2

[0024] Distill polyethylene glycol under reduced pressure for 10 hours at 90°C and a vacuum of 0.09 MPa to remove moisture; add 5.1 g of polyethylene glycol with a number average molecular weight of 1000, 2.27 g of iso Phorone diisocyanate, 20ml tetrahydrofuran, 1 drop of dibutyltin dilaurate, heated to 40°C under magnetic stirring, reacted for 7 hours; added 0.57g diselenodiol, maintained the temperature and continued to react for 7 hours; turned off the heating and cooled naturally to 20°C, add 0.63g diethanolamine, and react for 1.5 hours; add 1.27g isophorone diisocyanate to the product, mix evenly, and move it into a mold, and undergo cross-linking and curing in an oven at 40°C for 36 hours; the formed The block gel was removed from the mold, soaked in deionized water, and the water was changed every 6 hours. After 48 hours, the self-healing polyurethane hydrogel based on the dynamic covalent bond of double selenium could be obtained.

Embodiment 3

[0026] Distill polyethylene glycol under reduced pressure for 8 hours at 80°C and a vacuum of 0.09 MPa to remove moisture; add 3.8 g of polyethylene glycol with a number average molecular weight of 750, 2.27 g of iso Phorne diisocyanate, 15ml of acetone, 1 drop of dibutyltin dilaurate, heated to 50°C under magnetic stirring, and reacted for 8 hours; added 0.67g of diselenodiol, and continued to react for 8 hours at the temperature; turn off the heating, and put it in an ice bath Cool to 3°C, add 0.62g diethanolamine, keep the reaction in ice bath for 2 hours; add 1.52g isophorone diisocyanate to the product, mix evenly, and move it into a mold, and cross-link and mature in an oven at 30°C for 48 hours Demoulding the formed block gel, soaking it in deionized water, changing the water every 6 hours, after 48 hours, a self-healing polyurethane hydrogel based on the dynamic covalent bond of double selenium can be obtained.

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PUM

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Abstract

The invention discloses a preparation method of self-repaired polyurethane hydrogel based on a double-selenium dynamic covalent bond. The hydrogel is obtained by performing condensation and cross-linking reaction for diisocyanate, polyethylene glycol, double-selenium diol and diethanol amine and then immersing in deionized water. The hydrogel is based on the visible light dynamic reversibility of the double-selenium bond, the self-repairing for the damage can be realized under the radiation of moderate visible light, and good mechanical performance can still be kept by virtue of multiple repeated repairing. The hydrogel is a polyurethane structure, the polyethylene glycol is used as a hydrophilic soft section, the biological compatibility and the molecular structure designability are good, the mechanical performance can be effectively adjusted by adjusting a ratio of a soft section to a hard section of a molecular chain, and the requirements of the real application can be better met, so that the application prospect in the field of biological tissue engineering is wide.

Description

technical field [0001] The invention relates to a preparation method of a self-repairing hydrogel, in particular to the preparation of a self-repairing polyurethane hydrogel based on a double selenium dynamic covalent bond. Background technique [0002] Hydrogel is a polymer material with a three-dimensional network structure that is physically or chemically cross-linked. It uses water as a dispersion medium and can absorb a large amount of water to swell and maintain its structural stability. As a material with high water absorption and high water retention, hydrogel has been widely used in the fields of industry, agriculture and biological tissue engineering. However, in practical applications, due to the single or combined effects of external forces, light, heat, and chemicals, traditional hydrogels will produce microcracks inside that are difficult to detect and repair. The expansion and increase of these microcracks will reduce the mechanical properties of the material...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G18/66C08G18/48C08G18/32C08J3/075C08J3/24A61L27/18A61L27/52A61L27/50C08L75/08
CPCA61L27/18A61L27/50A61L27/52C08G18/3275C08G18/3897C08G18/4833C08G18/6688C08J3/075C08J3/24C08J2375/08C08L75/08
Inventor 金勇潘界舟金泓宇尹昕
Owner SICHUAN UNIV
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