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Extraction Method of Bivapirox Compounds in Anemarrhena Fibrous Roots

A technology of diphenpyrone and extraction method, applied in chemical instruments and methods, organic chemistry, sugar derivatives, etc., can solve the problems of low extract content and poor purification effect, and achieve high extract content, low price, The effect of good social benefit and economic value

Active Publication Date: 2019-10-22
CHENGUANG BIOTECH GRP HANDAN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, traditional Chinese medicine extraction mainly adopts solvent reflux extraction or leaching, and the purification method is generally macroporous adsorption resin, etc., but there are disadvantages of poor purification effect and low extract content.

Method used

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  • Extraction Method of Bivapirox Compounds in Anemarrhena Fibrous Roots
  • Extraction Method of Bivapirox Compounds in Anemarrhena Fibrous Roots
  • Extraction Method of Bivapirox Compounds in Anemarrhena Fibrous Roots

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: The method for extracting difenapyrone compounds from the roots of Anemarrhena vulgaris adopts the following specific process.

[0019] (1) The fibrous roots removed from the main roots of Anemarrhena are crushed into 20 meshes, then added to the supercritical fluid extraction kettle, and treated with CO 2 As solvent, 95wt% ethanol as entrainer, CO 2 The flow rate is 0.2L / min, the pressure of the extraction kettle is 10MPa, the temperature of the extraction kettle is 30°C, and the extraction is performed for 5 hours to obtain the extract.

[0020] (2) Concentrate the extract until it is alcohol-free, dilute with water to an aqueous extract solution with a concentration of 0.10g / mL, add a mixed solvent of dimethyl sulfoxide: chloroform=1:20 (volume), mixed solvent: extract Aqueous solution = 2:1 (volume), fully shaken for extraction, take the lower layer liquid and concentrate and dry, to obtain the dipyridone-like Anemarrhena sinensis root extract. The obtained ex...

Embodiment 2

[0021] Example 2: The method for extracting the dipyridone compound from the root of Anemarrhena vulgaris adopts the following specific process.

[0022] (1) The fibrous roots removed from the main roots of Anemarrhena are crushed into 30 meshes, then added to the supercritical fluid extraction kettle, and treated with CO 2 As solvent, with 50wt% methanol as entrainer, CO 2 The flow rate is 0.35L / min, the pressure of the extraction kettle is 30MPa, the temperature of the extraction kettle is 45°C, and the extraction is performed for 3.5h to obtain the extract.

[0023] (2) Concentrate the extract until it is alcohol-free, dilute with water to an aqueous extract solution with a concentration of 0.125g / mL, add a mixed solvent of dimethyl sulfoxide: chloroform=1:10 (volume), mixed solvent: extract Aqueous solution = 1:1 (volume), fully shaken for extraction, take the lower layer and concentrate and dry, to obtain a diproxypridone extract of Anemarrhena vulgaris root. The obtained extr...

Embodiment 3

[0024] Example 3: The method for extracting the dipyridone compound from the root of Anemarrhena vulgaris adopts the following specific process.

[0025] (1) The fibrous roots removed from the main roots of Anemarrhena are crushed into 40 meshes, and then added to the supercritical fluid extraction kettle. 2 As solvent, 30wt% n-propanol as entrainer, CO 2 The flow rate is 0.5L / min, the pressure of the extraction kettle is 50MPa, the temperature of the extraction kettle is 60°C, and the extraction is carried out for 2h to obtain the extract.

[0026] (2) Concentrate the extract to be alcohol-free, dilute with water to an aqueous extract solution with a concentration of 0.15g / mL, add a mixed solvent of dimethyl sulfoxide: chloroform=1:1 (volume), mixed solvent: extract Aqueous solution = 1:2 (volume), fully shake for extraction, take the lower layer liquid and concentrate and dry, to obtain the dipyridone-like Anemarrhena sinensis root extract. The obtained extract was qualitatively ...

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Abstract

The invention discloses a method for extracting a xanthones compound from rhizoma anemarrhenae. The method comprises the following steps: (1) crushing rhizoma anemarrhenae and then performing supercritical fluid extraction, thereby acquiring extract liquor; and (2) concentrating the extract liquor, adding water for diluting the extract liquor into an extraction aqueous solution, and then adding a mixed solvent of dimethyl sulfoxide and chloroform, fully oscillating for extracting, taking subnatant, concentrating and drying, thereby acquiring a xanthones rhizoma anemarrhenae extract. According to the method, the mixed solvent of dimethyl sulfoxide and chloroform is used for extracting, the physicochemical properties that dimethyl sulfoxide is capable of dissolving in water and chloroform but chloroform and water cannot mutually dissolve are fully utilized, so the purifying effect is better and the extract content is higher; supercritical extraction is adopted, so the extraction efficiency is higher; and mixed solvent extraction is adopted for purifying, so the purifying efficiency is high and the product content is higher.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, in particular to a method for extracting bisphenirone compounds from the roots of Anemarrhena vulgaris. Background technique [0002] Anemarrhena asphodeloides Bge. is the dried rhizome of the plant Anemarrhena asphodeloides Bge. of the Liliacea family. It has the effects of clearing heat, purging fire, promoting body fluid and moisturizing dryness; modern pharmacological studies have shown that it has pharmacological effects such as lowering blood sugar and resisting Alzheimer's disease (Ding Wei Mao. Experimental study on the anti-hepatitis B virus effect of Zhimuning[J]. China New Technology and New Products, 2009(17):9.; Li TJ, et al. Timosaponin B-Ⅱimproves memory and learning dysfunction induced by cerebral ischemia in rats[ J]. Neuroscience Letters, 2007, 421:147-151.). The chemical constituents of Anemarrhena are mainly diphenylpyrones and steroidal saponins, and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/04C07H1/08C07D407/04
CPCC07D407/04C07H1/08C07H17/04Y02P20/54
Inventor 黄燕巧薛强额尔敦巴雅尔李卫民程鑫颖
Owner CHENGUANG BIOTECH GRP HANDAN CO LTD
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