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Pharmaceutical composition for treating ulcerative colitis

A technology for ulcerative colitis and a composition, applied in the field of medicine, can solve problems such as undetermined microorganisms, and achieve the effects of relieving ulcerative colitis, fast onset, and alleviating symptoms

Inactive Publication Date: 2017-06-20
杨燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The acute phase resembles an inflammatory disease, but the organism responsible for the disease has not been clearly identified

Method used

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  • Pharmaceutical composition for treating ulcerative colitis
  • Pharmaceutical composition for treating ulcerative colitis
  • Pharmaceutical composition for treating ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0018] The characterization of experimental example 1 medicine of the present invention

[0019]

[0020] 1 H NMR(500MHz,DMSO)δ7.33-7.28(m,2H),7.24-7.19(m,1H),7.19-7.15(m,2H),3.40(s,2H),3.36-3.31(m,5H ),3.30-3.19(m,4H),3.14(s,2H),2.92-2.83(m,1H),2.47-2.41(m,1H),1.92-1.71(m,4H),1.54-1.41(m ,1H), 1.37-1.30(m,2H), 1.29-1.20(m,1H), 1.16-1.09(m,2H).

experiment example 2

[0021] Experimental example 2 Therapeutic effect of medicine of the present invention for ulcerative colitis

[0022] SD rats were selected, and 10 of them were selected as the normal group, and the remaining rats were treated with oxazolone (OXZ)-induced ulcerative colitis (UC) model. Shave the back skin of rats (2cm×2cm), label, add 0.2mL of 3% by weight OXZ (dissolved in absolute ethanol) dropwise to the shaved place, drop continuously for 7 days, fast for 24 hours on the 7th day, and use on the 8th day Rats were anesthetized with an appropriate amount of isoflurane, and then a polyethylene tube with a diameter of 2 mm was inserted into the large intestine about 8 cm, and the volume was 1.0 mL·kg -1 Infuse 1.0% by weight OXZ (dissolved in 50% by weight ethanol aqueous solution), and place the rat upside down for 1 min after injection to prevent reflux. The OXZ-induced UC rat model was successfully established. Feed normally after waking up.

[0023] On the first day after...

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Abstract

The present invention relates to a pharmaceutical composition for treating ulcerative colitis, which comprises a compound of the following formula or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier: Wherein R1 is independently selected from: alkyl, alkoxy or halogen. The medicine of the invention has a certain degree of relieving effect on colonic mucosa edema, erosion and ulcer, thereby protecting colonic mucosa and achieving the purpose of treating ulcerative colitis.

Description

technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to a pharmaceutical composition for treating ulcerative colitis. Background technique [0002] Ulcerative colitis is a chronic inflammatory colon disease of unknown etiology. Its acute phase resembles an inflammatory disease, but the microorganisms responsible for the disease have not been clearly identified. The disease causes inflammation of the colonic mucosa, which can extend to the submucosa in severe cases. Often, not only the colon but also the rectum and, in a few cases, the ileum are affected. Ulcer formation and its scope change with the development stage of the disease, and symptoms such as diarrhea and blood in the stool recur, seriously affecting the health of patients. Contents of the invention [0003] The object of the present invention is to provide a pharmaceutical composition for treating ulcerative colitis. [0004] In order to realize the obj...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/445A61P1/04
CPCA61K31/445
Inventor 杨燕
Owner 杨燕
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