Naproxen slow-release tablet and preparation method thereof
A naproxen and sustained-release tablet technology, applied in the field of drug naproxen, can solve problems such as nonconformity, and achieve the effects of good compatibility, stable release behavior, and low side effects
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Embodiment 1
[0031] Naproxen 250 g
[0032] Hypromellose 45g
[0033] Lactose 140g
[0034] Calcium bicarbonate 8g
[0037] Povidone K30 solution 6-20g
[0038] Preparation method: Take 250g of naproxen, 45g of hypromellose, 8g of calcium bicarbonate, and 40g of lactose, mix evenly, add the prepared povidone K30 solution to make soft material, and pass the soft material through a 16-mesh sieve to make wet granules , dried at 90-105°C, after the dry granules are sized, add 2 g of talc powder and 1 g of magnesium stearate, mix evenly, press into tablets, and coat.
Embodiment 2
[0040] Naproxen 250 g
[0041] Hypromellose 90g
[0042] Lactose 90g
[0043] Calcium bicarbonate 15g
[0044] Talc powder 5g
[0045] Magnesium stearate 3g
[0046] Povidone K30 6-20g
[0047] Preparation method: Take 250g of naproxen, 90g of hypromellose, 15g of calcium bicarbonate, and 90g of lactose and mix evenly, add povidone K30 solution to make soft material, and pass the soft material through a 16-mesh sieve to make wet granules. Dry at -105°C, after the dry granules are sized, add 5 g of talc powder and 3 g of magnesium stearate, mix evenly, press into tablets, and coat.
Embodiment 3
[0049] Naproxen 250 g
[0050] Hypromellose 150g
[0051] Lactose 30g
[0052] Calcium bicarbonate 25g
[0053] Talc powder 8g
[0055] Povidone K30 6-20g
[0056] Preparation method: Take 250g of naproxen, 150g of hypromellose, 25g of calcium bicarbonate, and 150g of lactose and mix evenly, add povidone K30 solution to make a soft material, and pass the soft material through a 16-mesh sieve to make wet granules. Dry at -105°C, after the dry granules are sized, add 8 g of talc powder and 4 g of magnesium stearate, mix evenly, press into tablets, and coat.
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