Polyethylene glycol-gambogic acid liposome, preparation method and application thereof in treatment of malignant tumors

A technology of polyethylene glycol and methoxypolyethylene glycol, which is applied in the direction of antineoplastic drugs, pharmaceutical formulations, organic active ingredients, etc., can solve problems such as short blood circulation time, poor preparation stability, and poor antitumor activity. Achieve the effects of improving bioavailability, delaying release, and improving water solubility
CN106913882AActive Publication Date: 2017-07-04SICHUAN PROVINCIAL PEOPLES HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SICHUAN PROVINCIAL PEOPLES HOSPITAL
Publication Date
2017-07-04

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Abstract

The invention discloses a polyethylene glycol-gambogic acid liposome, which is composed of a polyethylene glycol-gambogic acid conjugate, polyethylene glycol, vitamin E, cholesterol and phospholipid in a weight ratio of 1-10:0.5-2:0.05-0.2:1-4:10-30. According to the invention, an amphiphilic polymer PEG and an antitumor drug gambogic acid are connected with an ester bond into a conjugate amphipathic PEG-GA, and the PEG-GA is inserted into a liposome bimolecular layer to construct a nano targeted drug delivery system, the water solubility of the drug can be improved, also the drug stability and antitumor effect can be enhanced, drug accumulation in normal tissue can be reduced, the survival time of tumor-bearing mice is prolonged, the treatment efficacy is improved and the toxic and side effects are reduced. The invention also provides a preparation method and application of the liposome, and the liposome can be applied to treatment of lung cancer, ovarian cancer, breast cancer, colorectal cancer, melanoma, head and neck cancer, lymphoma or brain tumors.
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Description

technical field

[0001] The invention relates to the field of pharmaceutical preparations, in particular to a polyethylene glycol-gambogic acid liposome, a preparation method and its application in treating malignant tumors. Background technique

[0002] Natural products and their derivatives are playing an increasingly important role in the development of human health and medicine, Garcinia cambogia ( gamboge ): Garcinia Cambogia Garcinia hanbaryi Hook. f . Secreted dry resin. It is mainly produced in Cambodia, India, Thailand and Vietnam, and it is cultivated in Guangdong Province and Hainan Province of my country. It has long been recorded in Chinese medicine that Garcinia cambogia is cold in nature, sour, pungent, astringent, and poisonous. It has the effects of breaking blood, dispelling stagnation, detoxification, hemostasis, and killing insects. It has been used to treat scrofula, carbuncle, and boils since ancient times. Wait for the stubborn illness. Garcinia ca...

Claims

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