Unlock instant, AI-driven research and patent intelligence for your innovation.

Application of ginseng fruit anthocyanins in preparation of medicine for prevention of acute kidney injury (AKI)

A technology for acute kidney injury and fruit anthocyanins, applied in drug combinations, pharmaceutical formulations, organic active ingredients, etc., can solve problems such as unclear pharmacological effects

Active Publication Date: 2017-07-14
抚松县安东参业有限公司
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, although the renal damage protective activity of ginseng saponins has been reported frequently, it is not clear whether the anthocyanins in ginseng fruit have the pharmacological effect of protecting kidney damage

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0010] Experimental example. Protective effect of ginseng fruit anthocyanins on cisplatin-induced kidney injury in mice

[0011] 1 Materials and methods

[0012] 1.1 Animals: Male ICR mice, SPF grade, 5-6 weeks old, weighing 26-28g, purchased from Changchun Yisi Experimental Animal Technology Co., Ltd., certificate number: SCXK (Ji) 2011-0004, free to drink water, adapted to One week after sexual feeding, they were randomly divided into 4 groups and then experimented.

[0013] 1.2 Materials and instruments: ginseng fruit anthocyanins, prepared by the laboratory; cisplatin (99.0%), from Shanghai Siyu Chemical Technology Co., Ltd.; hematoxylin-eosin staining solution (H&E), Hoechst33258 staining solution, Shanghai Biyuntian Biotechnology Co., Ltd. Company; PAS staining solution, Beijing Regen Biotechnology Co., Ltd.; creatinine (CRE), blood urea nitrogen (BUN), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) and gluten Glutathione (GSH) kit was purchased from...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an application of ginseng fruit anthocyanins in preparation of a medicine for preventing cisplatin-mediated acute kidney injury (AKI) and belongs to the field of researching and development of medicine products. An animal experiment result proves that compared with a model group, the ginseng fruit anthocyanins can effectively reduce levels of BUN and CRE in serum and alleviate reduction of SOD, CAT, GSH and increase of level of MDA. In addition, the ginseng fruit anthocyanins can significantly inhibit increase of inflammatory factors, such as TNF-alpha and IL-1beta, in renal tissue, so that a medicine for preventing the AKI can be prepared with the effective part and a component comprising same. The medicine can be processed into any dosage forms in the prior art, such as tablets, capsules, powder injections, injections, pills, soft capsules, granules, patches, etc.

Description

technical field [0001] The invention discloses a new application of ginseng fruit anthocyanins in the preparation of medicines for preventing acute kidney injury, and belongs to the medical technical field of new biological activities of Chinese medicine extracts. Background technique [0002] The full name of cisplatin (cisplatin, CDDP) is cis-1, 2-dichlorodiamminoplatinum, which is one of the most effective and commonly used anti-tumor drugs in clinical practice, and is widely used in ovarian cancer, prostate cancer, and lung cancer. , nasopharyngeal carcinoma, malignant lymphoma, breast cancer, thyroid cancer and osteosarcoma and other solid tumors. However, severe side effects of cisplatin often limit its clinical application, especially kidney damage (nephrotoxicity). The curative effect of cisplatin is directly proportional to the dose, but the increase of its dose is limited by nephrotoxicity. Although protective measures such as hydration therapy are taken, the clin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P13/12
CPCA61K31/352
Inventor 李伟汤立民任素琴乞振兰赵立春刘志王梓张晶李慧萍
Owner 抚松县安东参业有限公司