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An external pharmaceutical composition for preventing and treating skin itching, its preparation method and application

A technology for external use of drugs and skin pruritus, which is applied in the directions of drug combinations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the problems of insignificant antipruritic effect, cumbersome preparation methods, complex ingredients, and the like, Achieve enhanced antipruritic effect, high patient compliance, and simple composition

Inactive Publication Date: 2019-12-27
MUDANJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Based on its pharmacological effects of sterilization, antipruritic, and anti-inflammatory, it has been reported in the literature that sapindus saponin is used in antipruritic and hypoallergenic soaps, essential oils, hair care products, washing powder, facial cleanser, etc. Saponin is only used as an auxiliary component, and a large number of other active components need to be added. The components are complex, the preparation method is cumbersome, and the antipruritic effect is not obvious. So far, there has been no report of using Sapindus saponin as the main active component for the prevention and treatment of skin itching

Method used

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  • An external pharmaceutical composition for preventing and treating skin itching, its preparation method and application
  • An external pharmaceutical composition for preventing and treating skin itching, its preparation method and application
  • An external pharmaceutical composition for preventing and treating skin itching, its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: the spray that prevents and treats pruritus

[0036] Sapindus total saponins 60g;

[0037] Eugenol 30g;

[0038] Ethanol 150mL;

[0039] Peppermint oil 15mL;

[0040] Add purified water to 1000mL.

[0041] Prepare as follows:

[0042] (1) Take by weighing total sapindus sapinsin, eugenol, ethanol and peppermint oil according to formula quantity;

[0043] (2) Stir evenly after adding sapindus saponin, eugenol, and ethanol into the batching tank, and stir evenly after adding peppermint oil;

[0044] (3) Add purified water to 1000mL and stir evenly;

[0045] (4) Filtrate, irradiate and sterilize and fill to obtain the spray for preventing and treating skin itching of the present invention.

Embodiment 2

[0046] Embodiment 2: Ointment for prevention and treatment of skin itching

[0047] Sapindus total saponins 80g;

[0048] Eugenol 20g;

[0049] Urea 10g;

[0050] Beeswax 890g.

[0051] Prepare as follows:

[0052] (1) Take Sapindus sapindus total saponins, eugenol and urea according to the formula quantity;

[0053] (2) Stir evenly after adding sapindus saponin, eugenol, and urea into the batching tank;

[0054] (3) After adding beeswax, stir evenly, irradiate and sterilize, and encapsulate, the ointment for preventing and treating skin itching of the present invention is obtained.

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Abstract

The invention relates to an external pharmaceutical composition for preventing and treating itchy skin and a preparation method and applications thereof. The pharmaceutical composition comprises sapindoside, eugenol, and pharmaceutically acceptable auxiliary material. Sapindoside and eugenol can generate a synergistic effect; the pharmaceutical composition has a prominent itch-relieving effect, can prevent and treat bacterial and / or fungal infection of damaged skins, is capable of avoiding and relieving secondary diseases of itchy skin, and obviously improves the life quality of patients. The components of the pharmaceutical composition are simple; and the pharmaceutical composition does not contain any hormone, antibiotic, surfactant, solubilizer, or antiseptic, is safe and nonirritant for skin, is convenient to use, has high patient obedience, and is used to prevent and treat itchy skin.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to an external pharmaceutical composition for preventing and treating skin pruritus, its preparation method and application. Background technique [0002] Skin pruritus is one of the common skin diseases. The pathogenesis is not yet clear. Usually there is no primary skin injury. It is generally considered to be a skin neurosis disease. According to the location of the disease, it is generally divided into generalized skin itching and local skin itching. Patients with itchy skin have to scratch repeatedly due to unbearable itching, which leads to skin damage, which not only seriously affects the daily life of patients, but also often leads to secondary diseases such as pigmentation, bacterial and / or fungal infections, and further Worse. [0003] Due to the unclear pathogenesis, the current clinical treatment for pruritus is generally aimed at alleviating symptoms, including ext...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K31/085A61K9/12A61K47/44A61K9/06A61K47/46A61P17/04
CPCA61K9/0014A61K9/06A61K9/12A61K31/085A61K31/704A61K47/44A61K47/46A61K2300/00
Inventor 初金玉张万里刘英伟梁绍栋孟祥慧
Owner MUDANJIANG MEDICAL UNIV
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