Isobenzofuran compound capable of improving cigarette suction throat comfort and preparation method and application of isobenzofuran compound

A technology of comfort and compounds, applied in the field of phytochemistry, can solve the problems of reducing the throat irritation of cigarette smoking, and achieve the effect of improving the quality of cigarette smoking, good application prospects, and reducing irritation

Active Publication Date: 2017-07-18
CHINA TOBACCO YUNNAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention separates and obtains an isobenzofuran compound from tobacco. When the compound is added to the cigarette filter, it can significantly reduce the irritation of the throat when cigarettes are sucked, and has obvious moisturizing effect, and can be used as a tobacco additive to improve Cigarette smoking quality use, no relevant reports have been found so far

Method used

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  • Isobenzofuran compound capable of improving cigarette suction throat comfort and preparation method and application of isobenzofuran compound
  • Isobenzofuran compound capable of improving cigarette suction throat comfort and preparation method and application of isobenzofuran compound
  • Isobenzofuran compound capable of improving cigarette suction throat comfort and preparation method and application of isobenzofuran compound

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preparation example Construction

[0044] The preparation method of the isobenzofuran compound of the present invention is prepared by taking tobacco as raw material, extracting extract, organic solvent extraction, MCI decolorization, silica gel column chromatography and high performance liquid chromatography separation steps, specifically:

[0045] A. Extraction of extract: crush the tobacco to 20-40 meshes, ultrasonically extract 2-5 times with a solvent 5-10 times the weight of tobacco, 30-60 minutes each time, combine the extracts and filter, and concentrate the filtrate under reduced pressure to the original 1 / 4 of the volume, let it stand, filter out the precipitate, and then concentrate the resulting filtrate under reduced pressure into extract a;

[0046] B. Organic solvent extraction: add water with a weight 1 to 2 times the weight of the extract a to the extract a, then extract 3 to 5 times with an organic solvent equal to the volume of water, combine the organic solvent extraction phases, and then com...

Embodiment 1

[0057] The tobacco samples were from Yuxi, Yunnan, and the variety was Yuxi K326.

[0058] Take 4.4 kg of dried tobacco, coarsely crush it to 30 mesh, and ultrasonically extract 4 times with 70% acetone aqueous solution 10 times the weight of the tobacco, 60 minutes each time, and combine the extracts; filter the extracts, and concentrate under reduced pressure to 1% of the original volume. / 4; leave standstill, filter out the sediment, concentrate under reduced pressure into 120g extract a;

[0059] Add 240g of water to extract a, extract 5 times with chloroform equal to the volume of water, combine the organic solvent extraction phase, and concentrate under reduced pressure to obtain 80g of extract b;

[0060] Add 240 g of methanol to the extract b to dissolve, and after the extract b is completely dissolved, put it on the MCI column, elute with 6 liters of 90% methanol aqueous solution, combine the eluents, and concentrate under reduced pressure to obtain 62 g of extract c;...

Embodiment 2

[0063] The tobacco samples were from Dali, Yunnan, and the variety was Yunyan 200.

[0064] Take 10 kg of dried tobacco, coarsely crush it to 40 mesh, and ultrasonically extract it with methanol 5 times the weight of the tobacco for 5 times, each time for 30 minutes, and combine the extracts; filter the extracts, concentrate under reduced pressure to 1 / 4 of the original volume; place, filter the precipitate, and concentrate under reduced pressure to obtain 300g extract a;

[0065] Add 350g of water to the extract a, extract 3 times with dichloromethane equal to the volume of water, combine the organic solvent extraction phase, and concentrate under reduced pressure to 210g of extract b;

[0066] Add 630g of 50% methanol aqueous solution to the extract b to dissolve, after the extract b is completely dissolved, put it on the MCI column, elute with 10 liters of 95% methanol aqueous solution, combine the eluents, and concentrate under reduced pressure Obtain 150g extract c;

[...

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Abstract

The invention relates to an isobenzofuran compound capable of improving the cigarette suction throat comfort and a preparation method and application of the isobenzofuran compound, and belongs to the technical field of phytochemistry. The compound is separated from cigarettes and tobaccos; the compound is named 5-methoxy-2,2-dimethyl-7,9-dihydro-2H-furo[3,4-]chromene, the English name is 5-methoxy-2,2-dimethyl-7,9-dihydro-2H-furo[3,4-]chromene, the molecular formula is C14H16O3 and the structural formula is as shown in a formula (I). According to the preparation method, the compound is prepared through extract extraction, organic solvent extraction, MCI decoloration, silica-gel column chromatography and high-performance liquid chromatography separation on the cigarettes and tobaccos as the raw material. By adding the compound to a cigarette filter, the cigarette suction throat comfort can be improved and the compound has an obvious throat moistening effect.

Description

technical field [0001] The invention belongs to the technical field of phytochemistry, and specifically relates to an isobenzofuran compound extracted from tobacco for the first time, a preparation method and application thereof. The compound has the effect of significantly improving the throat comfort of cigarette smoking, and can be used as a cigarette mouthpiece additive to improve the smoking quality of cigarettes. Background technique [0002] Nicotiana is an annual or limited perennial herbaceous plant belonging to the family Solanaceae. Among them, N.tabacum L. is the most widely cultivated. Its mature leaves are important raw materials for the cigarette industry and a crop with high economic value. In addition to being mainly used for smoking, tobacco has other extensive uses. At the same time, tobacco is the plant with the most complex chemical composition in the world, and its secondary metabolites are very rich. After decades of research, people have identified m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/04A24D3/14A24B15/40
CPCA24B15/406A24D3/14C07D493/04
Inventor 刘春波杨光宇申钦鹏刘志华唐石云蒋薇王晋何沛张凤梅司晓喜尤俊衡李振杰朱瑞芝王昆淼苏钟璧崔婷惠
Owner CHINA TOBACCO YUNNAN IND
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