Technology for extracting palmatine from common fibraurea stem

A technology of palmetine and process, applied in the field of palmetine preparation, can solve the problems of low extraction rate and purity of palmetine

Inactive Publication Date: 2017-07-25
南宁馨艺荣生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention provides a process for extracting palmatine from Huangteng, to solve the problem of low extraction rate and purity of palmetine produced in the prior art

Method used

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  • Technology for extracting palmatine from common fibraurea stem
  • Technology for extracting palmatine from common fibraurea stem

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A process for extracting palmatine from Huangteng, comprising the following steps:

[0040] S1: Pulverizing the vine root and passing it through a 60-mesh sieve to obtain vine root powder;

[0041] S2: Add 14 times the weight of 66% methanol to the yellow vine powder prepared in step S1, and extract twice under ultrasonic reflux under water bath conditions, the frequency of each ultrasonic wave is 580W, the temperature is 46 ° C, and the time is 15 min. After completion, combine the extracts, adjust the pH value of the extracts to 4.2, control the temperature at 46°C, decolorize and remove impurities by activated carbon for 1 hour, and obtain a decolorized solution after filtration;

[0042] S3: Concentrate and dry the primary decolorization solution obtained in step S2 to obtain an extract extract, which is dissolved in water at 48°C with 5.5 times the volume of the extract extract, extracted twice with anhydrous ethyl acetate solvent, and continued to use Anhydrous e...

Embodiment 2

[0048] A process for extracting palmatine from Huangteng, comprising the following steps:

[0049] S1: Pulverizing the vine root and passing it through a 40-mesh sieve to obtain the vine root powder;

[0050] S2: Add 13 times its weight of 61% methanol to the yellow vine powder prepared in step S1, and extract twice under ultrasonic reflux under water bath conditions, the frequency of each ultrasonic wave is 520W, the temperature is 44°C, and the time is 16min. After completion, combine the extracts, adjust the pH value of the extracts to 3.8, control the temperature at 42°C, decolorize and remove impurities by activated carbon for 1.3 hours, and obtain a decolorized solution after filtration;

[0051] S3: Concentrate and dry the primary decolorization solution obtained in step S2 to obtain an extract extract, which is dissolved in water at 42° C. with 5 times the volume of the extract extract, extracted twice with anhydrous ethyl acetate solvent, and continued to use Anhydro...

Embodiment 3

[0057] A process for extracting palmatine from Huangteng, comprising the following steps:

[0058] S1: Pulverizing the vine root and passing it through an 80-mesh sieve to obtain vine root powder;

[0059] S2: Add 15 times its weight of 72% methanol to the yellow vine powder prepared in step S1, and extract it under ultrasonic reflux for 3 times under water bath conditions. The frequency of each ultrasonic wave is 700W, the temperature is 48°C, and the time is 12min. After completion, combine the extracts, adjust the pH value of the extracts to 4.5, control the temperature at 50°C, decolorize and remove impurities by activated carbon for 0.7h, and obtain a decolorized solution after filtration;

[0060] S3: Concentrate and dry the primary decolorization solution obtained in step S2 to obtain an extract extract, which is dissolved in water at 50° C. with 5.6 times the volume of the extract extract, and extracted 3 times with anhydrous ethyl acetate solvent, and then continue to...

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Abstract

The invention discloses a technology for extracting palmatine from a common fibraurea stem and belongs to the technical field of palmatine preparation. The palmatine is prepared through the steps of crushing, primary decoloration, crystallization, secondary decoloration, recrystallization, extraction, separation and purification, concentration and crystallization and drying. The yield of the palmatine prepared by the method is greater than 38.25% and the purity is greater than 98.31% and higher than that of the palmatine prepared in the prior art, and the palmatine can be used as a qualitative and quantitative reference substance.

Description

[0001] 【Technical field】 [0002] The present invention relates to the technical field of preparation of palmatine, in particular to a process for extracting palmetine from Huangteng. [0003] 【Background technique】 [0004] Huangtengsu (rheumatin) is a pure natural herbal medicine independently developed by our country. It has been included in the Chinese Pharmacopoeia. Inflammation and enhance the body's immunity. It is used for gynecological inflammation, bacillary dysentery, enteritis, respiratory tract and urinary tract infection, surgical infection, and conjunctivitis. 1. Gynecological inflammation, acute and chronic pelvic inflammatory disease, acute and chronic adnexitis, cervical erosion, endometritis, fungal vaginitis, puerperal infection, etc. 2. Urinary tract infection; 3. Surgical infection, conjunctivitis; 4. Respiratory tract infection and other general medicine. It has an inhibitory effect on fungi, especially against Candida albicans, gypsum-like hairy fung...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D455/03
CPCC07D455/03Y02P20/54
Inventor 梁可文谢冬养黄能
Owner 南宁馨艺荣生物科技有限公司
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